Parathyroid hormone and phosphate homeostasis in patients with Bartter and Gitelman syndrome : an international cross-sectional study
Verploegen, Maartje F A (Radboud University Medical Center)
Vargas-Poussou, Rosa (Hôpital Européen Georges Pompidou Assistance Publique Hôpitaux de Paris)
Walsh, Stephen B (University College London)
Alpay, Harika (Marmara University)
Amouzegar, Atefeh (Hospital Universitari Vall d'Hebron)
Ariceta Iraola, Gema (Iran University of Medical Sciences)
Atmis, Bahriye (Cukurova University Faculty of Medicine)
Bacchetta, Justine (University Children's Hospital (França))
Bárány, Peter (Karolinska University Hospital and Karolinska Institutet (Suècia))
Baron, Stéphanie (Hôpital Européen Georges Pompidou Assistance Publique Hôpitaux de Paris)
Bayrakci, Umut Selda (Üniversiteler Mahallesi Bilkent Caddesi)
Belge, Hendrica (University of Groningen)
Besouw, Martine (Hôpital Européen Georges Pompidou Assistance Publique Hôpitaux de Paris)
Blanchard, Anne (Université de Paris)
Bökenkamp, Arend (Universiteit Amsterdam)
Boyer, Olivia (Paris University)
Burgmaier, Kathrin (University of Cologne)
Calò, Lorenzo A (University of Padova)
Decramer, Stéphane (Toulouse University Hospital)
Devuyst, Olivier (University of Zurich)
van Dyck, Maria (University Hospitals Leuven (Bèlgica))
Ferraro, Pietro Manuel (Fondazione Policlinico Universitario A. Gemelli)
Fila, Marc (University Hospital of Montpellier (França))
Francisco, Telma (Centro Hospitalar Universitário de Lisboa Central)
Ghiggeri, Gian Marco (Istituto Giannina Gaslini)
Gondra, Leire (Hospital Universitario de Cruces (Barakaldo, País Basc))
Guarino, Stefano (Università degli Studi della Campania 'Luigi Vanvitelli')
Hooman, Nakysa (Iran University of Medical Sciences)
Hoorn, Ewout J (University Medical Centre Rotterdam)
Houillier, Pascal (Hôpital Européen Georges Pompidou Assistance Publique Hôpitaux de Pari)
Kamperis, Konstantinos (Aarhus University Hospital (Aarhus, Dinamarca))
Kari, Jameela A (King Abdulaziz University)
Konrad, Martin (University Hospital of Münster (Alemanya))
Levtchenko, Elena (University Hospitals Leuven (Bèlgica))
Lucchetti, Laura (Bambino Gesù Children's Hospital)
Lugani, Francesca (Children's Hospital of Lucerne)
Marzuillo, Pierluigi (Università degli Studi della Campania 'Luigi Vanvitelli')
Mohidin, Barian (University College London)
Neuhaus, Thomas J (Children's Hospital of Lucerne)
Osman, Abdaldafae (Great Ormond Street Hospital for Children (Londres))
Papizh, Svetlana (Pirogov Russian National Research Medical University)
Perelló, Manel (Hospital Universitari Vall d'Hebron)
Rookmaaker, Maarten B (University Medical Centre Utrecht)
Conti, Valerie Said (Mater Dei Hospital Malta)
Santos, Fernando (Universidad de Oviedo)
Sawaf, Ghalia (Damascus Hospital)
Serdaroglu, Erkin (Dr Behçet Uz Children's Hospital)
Szczepanska, Maria (SUM in Katowice)
Taroni, Francesca (Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico)
Topaloglu, Rezan (Hacettepe University School of Medicine)
Trepiccione, Francesco (University of Campania "L. Vanvitelli")
Vidal, Enrico (University of Udine)
Wan, Elizabeth R (Istanbul University)
Weber, Lutz (Uniklinik Köln (Colònia, Alemanya))
Yildirim, Zeynep Yuruk (Istanbul University)
Yüksel, Selçuk (Pamukkale University School of Medicine)
Zlatanova, Galia (University Children's Hospital Medical University (Bulgària))
Bockenhauer, Detlef (University College London)
Emma, Francesco (Bambino Gesù Children's Hospital)
Nijenhuis, Tom (Radboud University Medical Center)
Universitat Autònoma de Barcelona

Fecha:	2022
Resumen:	Small cohort studies have reported high parathyroid hormone (PTH) levels in patients with Bartter syndrome and lower serum phosphate levels have anecdotally been reported in patients with Gitelman syndrome. In this cross-sectional study, we assessed PTH and phosphate homeostasis in a large cohort of patients with salt-losing tubulopathies. Clinical and laboratory data of 589 patients with Bartter and Gitelman syndrome were provided by members of the European Rare Kidney Diseases Reference Network (ERKNet) and the European Society for Paediatric Nephrology (ESPN). A total of 285 patients with Bartter syndrome and 304 patients with Gitelman syndrome were included for analysis. Patients with Bartter syndrome type I and II had the highest median PTH level (7. 5 pmol/L) and 56% had hyperparathyroidism (PTH >7. 0 pmol/L). Serum calcium was slightly lower in Bartter syndrome type I and II patients with hyperparathyroidism (2. 42 versus 2. 49 mmol/L; P =. 038) compared to those with normal PTH levels and correlated inversely with PTH (r −0. 253; P =. 009). Serum phosphate and urinary phosphate excretion did not correlate with PTH. Overall, 22% of patients had low serum phosphate levels (phosphate-standard deviation score < −2), with the highest prevalence in patients with Bartter syndrome type III (32%). Serum phosphate correlated with tubular maximum reabsorption of phosphate/glomerular filtration rate (TmP/GFR) (r 0. 699; P <. 001), suggesting renal phosphate wasting. Hyperparathyroidism is frequent in patients with Bartter syndrome type I and II. Low serum phosphate is observed in a significant number of patients with Bartter and Gitelman syndrome and appears associated with renal phosphate wasting.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Bartter syndrome ; Gitelman syndrome ; Parathyroid hormone ; Phosphate ; Salt losing tubulopathies
Publicado en:	Nephrology Dialysis Transplantation, Vol. 37 (february 2022) , p. 2474-2486, ISSN 1460-2385

DOI: 10.1093/ndt/gfac029
PMID: 35137195

13 p, 785.5 KB

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