Case Report : Neuroblastoma-Like Schwannoma in a Domestic Short-Haired Cat
Chen, Vivian S. (Charles River Laboratories)
Bollen, Andrew W. (University of California. Department of Pathology, Microbiology and Immunology)
Marco Salazar, Paola (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Higgins, Robert J. (University of California. Department of Pathology, Microbiology and Immunology)
Sisó, Sílvia (Codiak BioSciences. Translational Imaging and Pathology)

Fecha:	2022
Resumen:	An axillary mass was detected in a 6-year-old, neutered, male, domestic short-haired cat during a wellness exam. Gross examination following surgical removal revealed a discrete, deep subcutaneous, discoid mass that was between 0. 5- and 0. 7-cm-in-diameter and diffusely firm and white. Histologically, the mass was well-demarcated, partially encapsulated, and expanded the panniculus carnosus. It was composed of tightly packed, giant rosettes of radially arranged fusiform cells stacked in one to 10 layers with peripherally palisading nuclei and with centrally oriented, fibrillary, cytoplasmic processes, and collagenous fibers. Laminin immunoreactivity and ultrastructural examination highlighted a continuous basal lamina outside the plasma membrane of each neoplastic cell. Neoplastic cells were immunoreactive for GFAP, S100, periaxin, and Sox-10 and were immunonegative for synaptophysin, smooth muscle actin, and pancytokeratin. Collective findings were consistent with a diagnosis of neuroblastoma-like schwannoma. This is the first veterinary report of this rare variant of benign schwannoma.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Schwannoma ; Neurilemoma ; Peripheral nerve sheath tumor ; Neuroblastoma ; Cat
Publicado en:	Frontiers in Veterinary Science, Vol. 9 (june 2022) , ISSN 2297-1769

DOI: 10.3389/fvets.2022.905302
PMID: 35782550

5 p, 2.2 MB

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