Detection of vector-borne pathogens in owned dogs with cranial cruciate ligament rupture living in the Mediterranean area
Tabar, Maria Dolores (Hospital Veterinario San Vicente (Alacant))
Tabar, Javier (Hospital Veterinario San Vicente (Alacant))
Naranjo Freixa, Carolina (IDEXX Laboratories)
Altet Sanahujes, Laura (Universitat Autònoma de Barcelona. Vetgenomics)
Roura, Xavier (Universitat Autònoma de Barcelona. Hospital Clínic Veterinari)

Fecha:	2022
Resumen:	Cranial cruciate ligament rupture (CCLR) results from a multifactorial degenerative process that leads to rupture of the ligament. Vector-borne pathogens (VBP) in dogs can induce joint disease but their role in CCLR has not been previously investigated. The aim of the present work is to evaluate the prevalence of VBP in dogs with CCLR. This was a prospective study that included 46 dogs presented for CCLR surgical treatment and 16 control dogs euthanized for diseases unrelated to the joints. Specimens collected included blood, synovial fluid, and synovial membrane biopsy. Pathogen testing consisted of serology for Leishmania infantum (quantitative ELISA), Ehrlichia canis/ewingii, Borrelia burgdorferi, Anaplasma phagocytophilum / platys, and Dirofilaria immitis (4DX IDEXX test), and PCR for L. infantum, Ehrlichia / Anaplasma spp. , Bartonella spp. , piroplasms (Babesia spp. and Theileria spp. ), and filariae (D. immitis, Dirofilaria repens, Acanthocheilonema dracunculoides, Acanthocheilonema reconditum, and Cercopithifilaria spp. ) on both EDTA-whole blood (EB) and synovial fluid (SF) samples. SF cytology and histopathological evaluation of synovial membrane were also performed. The prevalence of VBP was 19. 6% in the CCLR group and 18. 8% in the control group, with no statistical difference among them. The presence of synovitis was not more frequent in CCLR dogs (45. 6%) than in control dogs (43. 7%). Lymphoplasmacytic infiltration was the most common inflammatory pattern detected in the joints of both groups of dogs. This study failed to demonstrate a role of canine VBP in CCLR or the presence or different pattern of joint inflammation in pathogen-positive dogs. The online version contains supplementary material available at 10. 1186/s13071-022-05205-x.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Leishmania ; Ehrlichia ; Anaplasma ; Bartonella ; Piroplasms ; Filariae ; Osteoarthritis
Publicado en:	Parasites & vectors, Vol. 15 (may 2022) , ISSN 1756-3305

DOI: 10.1186/s13071-022-05205-x
PMID: 35534857

6 p, 796.3 KB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Grup de Recerca Malalties infeccioses-inflamatòries en animals de companyia (MIAC)
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