Use of preventive measures and serological screening tools for Leishmania infantum infection in dogs from Europe
Baxarias, Marta (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Homedes, Josep (Ecuphar Veterinaria SLU)
Mateu, Cristina (Ecuphar Veterinaria SLU)
Attipa, Charalampos (Liverpool School of Tropical Medicine. Department of Tropical Disease Biology)
Solano Gallego, Laia (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)

Fecha:	2022
Resumen:	There are several screening tools for detecting Leishmania infantum infection in dogs and various preventive measures to protect against it. Some studies have investigated them, but not many have described their current use. The aim of this study was to investigate which preventive measures and serological screening tools for L. infantum infection were employed from 2012 to 2018 in dogs from different endemic European countries. A set of electronic datasheets was completed for each dog from several veterinary centres. Classification of preventive measures included: (1) repellents, (2) vaccines and (3) immunomodulators. Classification of serological tests included the: (1) direct agglutination test (DAT), (2) enzyme-linked immunosorbent assay (ELISA), (3) indirect immunofluorescence (IFI), (4) rapid tests and (5) other assays. Dogs were also classified depending on their risk of exposure and living area. Information from 3762 dogs was gathered. Preventive measures were applied in 91. 5% of dogs and the most frequently used were repellents (86. 2%) followed by vaccines (39. 8%) and Leisguard ® (15. 3%). The different types of repellents (collar and spot-on) were used similarly. A combination of a vaccine and repellents was preferred in the high-risk group while the low-risk preferred a combination of Leisguard ® and a repellent (Chi-square test: X 2 = 88. 41, df = 10, P < 0. 001). Furthermore, all preventive measures were similarly used through the years except for repellents, which were predicted to have a small increase of use each year. Regarding serological screening tools, the most used were rapid and ELISA tests. Rapid tests, ELISA tests and DAT were used similarly through the years, but a significant change was found in the use of IFI and other assays whose use decreased a little each year. Repellents were the preferred measure, while vaccines and Leisguard ® were second-line options. Some dogs were not treated by any measures, which highlights the need for dog owner education. Moreover, there seems to be a preference for rapid tests in the clinical setting to detect specific L. infantum antibodies while ELISA or IFI are less often employed. This underlines an increasing problem, as qualitative rapid tests have a variable diagnostic performance limiting the adequate diagnosis of seropositive dogs in endemic areas. The online version contains supplementary material available at 10. 1186/s13071-022-05251-5.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Leishmaniosis ; Canine ; Prevention ; Screening diagnostic tools ; Europe
Publicado en:	Parasites & vectors, Vol. 15 (may 2022) , ISSN 1756-3305

DOI: 10.1186/s13071-022-05251-5
PMID: 35534848

11 p, 1.8 MB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Grup de Recerca Malalties infeccioses-inflamatòries en animals de companyia (MIAC)
Artículos > Artículos de investigación
Artículos > Artículos publicados