Comorbidities at diagnosis, survival, and cause of death in patients with chronic lymphocytic leukemia : A population-based study
Villavicencio, Alicia (Institut d'Investigació Biomèdica de Girona)
Solans, Marta (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Zacarías-Pons, Lluís (Research Group on Aging. Disability and Health. Girona Biomedical Research Institute (IDIBGI))
Vidal, Anna (Institut d'Investigació Biomèdica de Girona)
Puigdemont, Montse (Institut d'Investigació Biomèdica de Girona)
Roncero, Josep Maria (Hospital Universitari de Girona Doctor Josep Trueta)
Saez, Marc (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Marcos-Gragera, Rafael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	This study aimed to examine the prevalence of comorbidities in patients diagnosed with chronic lymphocytic leukemia (CLL), and to assess its influence on survival and cause-specific mortality at a population-based level. Incident CLL cases diagnosed in the Girona province (Spain) during 2008-2016 were extracted from the Girona Cancer Registry. Rai stage and presence of comorbidities at diagnosis, further categorized using the Charlson comorbidity index (CCI), were obtained from clinical records. Observed (OS) and relative survival (RS) were estimated and Cox's proportional hazard models were used to explore the impact of comorbidity on mortality. Among the 400 cases included in the study, 380 (99. 5%) presented at least one comorbidity at CLL diagnosis, with diabetes without end organ damage (21%) being the most common disease. 5-year OS and RS were 68. 8 (95% CI: 64. 4-73. 6) and 99. 5 (95% CI 3. 13-106. 0), respectively, which decreased markedly with increasing CCI, particularly in patients with CCI ≥ 3. Multivariate analysis identified no statistically significant association between the CCI and overall CLL-related or CLL-unrelated mortality. In conclusion, a high CCI score negatively influenced the OS and RS of CLL patients, yet its effect on mortality was statistically non-significant when also considering age and the Rai stage.
Grants:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2017-SGR-733 Ministerio de Ciencia e Innovación PI11/02213 Ministerio de Economía y Competitividad PI15/00966
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	International journal of environmental research and public health, Vol. 18 Núm. 2 (february 2021) , p. 1-10, ISSN 1660-4601

DOI: 10.3390/ijerph18020701
PMID: 33467494

10 p, 887.4 KB

The record appears in these collections:
Articles > Research articles
Articles > Published articles