The role of high serum triglyceride levels on pancreatic necrosis development and related complications
Hidalgo, Nils Jimmy (Hospital Universitari Vall d'Hebron)
Pando, Elizabeth (Hospital Universitari Vall d'Hebron)
Alberti Delgado, Piero (Hospital Universitari Vall d'Hebron)
Mata, Rodrigo (Hospital Universitari Vall d'Hebron)
Fernandes, Nair (Hospital Universitari Vall d'Hebron.)
Adell-Trapé, Montse (Hospital Universitari Vall d'Hebron)
Villasante, Sara (Hospital Universitari Vall d'Hebron)
Blanco, Laia (Hospital Universitari Vall d'Hebron)
Balsells Valls, Joaquim (Hospital Universitari Vall d'Hebron)
Charco, Ramon (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Fecha:	2023
Resumen:	The relevance of elevated serum triglyceride (TG) levels in the early stages of acute pancreatitis (AP) not induced by hypertriglyceridemia (HTG) remains unclear. Our study aims to determine the role of elevated serum TG levels at admission in developing pancreatic necrosis. We analyzed the clinical data collected prospectively from patients with AP. According to TG levels measured in the first 24 h after admission, we stratified patients into four groups: Normal TG (< 150 mg/dL), Borderline-high TG (150-199 mg/dL), High TG (200-499 mg/dL) and Very high TG (≥ 500 mg/dL). We analyzed the association of TG levels and other risk factors with the development of pancreatic necrosis. A total of 211 patients were included. In the Normal TG group: 122, in Borderline-high TG group: 38, in High TG group: 44, and in Very high TG group: 7. Pancreatic necrosis developed in 29. 5% of the patients in the Normal TG group, 26. 3% in the Borderline-high TG group, 52. 3% in the High TG group, and 85. 7% in the Very high TG group. The trend analysis observed a significant association between higher TG levels and pancreatic necrosis (p = 0. 001). A multivariable analysis using logistic regression showed that elevated TG levels ≥ 200 mg/dL (High TG and Very high TG groups) were independently associated with pancreatic necrosis (OR: 3. 27, 95% CI − 6. 27, p < 0. 001). An elevated TG level at admission ≥ 200 mg/dl is independently associated with the development of pancreatic necrosis. The incidence of pancreatic necrosis increases proportionally with the severity of HTG. The online version contains supplementary material available at 10. 1186/s12876-023-02684-9.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Acute pancreatitis ; Triglyceride ; Pancreatic necrosis ; Hypertriglyceridemia
Publicado en:	BMC Gastroenterology, Vol. 23 (february 2023) , ISSN 1471-230X

DOI: 10.1186/s12876-023-02684-9
PMID: 36829113

10 p, 1.2 MB

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