Exploring the Biological Properties of Zn(II) Bis thiosemicarbazone Helicates
Fernández-Fariña, Sandra (Universidade de Santiago de Compostela)
Velo-Heleno, Isabel (Universidade de Santiago de Compostela)
Carballido, Rocío (Universidade de Santiago de Compostela)
Martínez-Calvo, Miguel (Universidade de Santiago de Compostela)
Barcia, Ramiro (Universidade de Santiago de Compostela)
Palacios Bonilla, Òscar (Universitat Autònoma de Barcelona. Departament de Química)
Capdevila Vidal, Mercè (Universitat Autònoma de Barcelona. Departament de Química)
González-Noya, Ana M. (Universidade de Santiago de Compostela)
Pedrido, Rosa (Universidade de Santiago de Compostela)

Date:	2023
Abstract:	The design of artificial helicoidal molecules derived from metal ions with biological properties is one of the objectives within metallosupramolecular chemistry. Herein, we report three zinc helicates derived from a family of bis thiosemicarbazone ligands with different terminal groups, Zn(L Me)∙2HO 1, Zn(L Ph)∙2HO 2 and Zn(L PhNO2) 3, obtained by an electrochemical methodology. These helicates have been fully characterized by different techniques, including X-ray diffraction. Biological studies of the zinc(II) helicates such as toxicity assays with erythrocytes and interaction studies with proteins and oligonucleotides were performed, demonstrating in all cases low toxicity and an absence of covalent interaction with the proteins and oligonucleotides. The in vitro cytotoxicity of the helicates was tested against MCF-7 (human breast carcinoma), A2780 (human ovarian carcinoma cells), NCI-H460 (human lung carcinoma cells) and MRC-5 (normal human lung fibroblasts), comparing the IC values with cisplatin. We will try to demonstrate if the terminal substituent of the ligand precursor exerts any effect in toxicity or in the antitumor activity of the zinc helicates.
Grants:	Ministerio de Ciencia, Innovación y Universidades CTQ2017-90802-REDT Ministerio de Ciencia e Innovación RED2018-102471-T Agencia Estatal de Investigación Project PID2021-127531NB-I00
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Bisthiosemicarbazone ligands ; Zinc ; Helicates ; Biological activity
Published in:	International journal of molecular sciences, Vol. 24, Num. 3 (January 2023) , art. 2246, ISSN 1422-0067

DOI: 10.3390/ijms24032246
PMID: 36768568

16 p, 5.1 MB

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