Aspergillus conidia and allergens in outdoor environment : a health hazard?
De Linares Fernández, Concepción (Universidad de Granada. Departamento de Botánica)
Navarro, David (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia)
Puigdemunt, Rut (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals)
Belmonte, Jordina (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals)

Date:	2023
Description:	11 pàg.
Abstract:	Aspergillus is a genus of saprophytic fungus widely distributed in the environment and associated with soil, decaying vegetation, or seeds. However, some species, such as A. fumigatus, are considered opportunistic pathogens in humans. Their conidia (asexual spores) and mycelia are associated with clinical diseases known as invasive aspergillosis (IA), mainly related to the respiratory tract, such as allergic asthma, allergic bronchopulmonary aspergillosis (ABPA), or hypersensitivity. However, they can also disseminate to other organs, particularly the central nervous system. Due to the dispersal mechanism of the conidia through the air, airborne fungal particle measurement should be used to prevent and control this mold. This study aims to measure the outdoor airborne concentration of Aspergillus conidia and the Asp f 1 allergen concentration in Bellaterra (Barcelona, Spain) during 2021 and 2022, and to compare their dynamics to improve the understanding of the biology of this genus and contribute to a betterdiagnosis, prevention, and therapeutic measures in the face of possible health problems. The results show that both particles were airborne nearly all year round, but their concentrations showed no correlation. Due to Asp f 1 not being present in the conidia itself but being detectable during their germination and in hyphal fragments, we report the relevance of the aero-immunological analysis as a methodology to detect the potential pathogenic hazard of this fungus.
Grants:	Ministerio de Ciencia e Innovación CEX2019-000940-M Agencia Estatal de Investigación CTM2017-89565-C2-1-P Ministerio de Economía y Competitividad CGL2012-39523-C02-01 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-00519 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1692
Note:	Unidad de excelencia María de Maeztu CEX2019-000940-M
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Aerobiology ; Asp f 1 ; ELISA ; Fungal spores ; High volume sampler ; Hirst sampler
Published in:	Journal of Fungi, Vol. 9, issue 6 (June 2023) , art. 624, ISSN 2309-608X

DOI: 10.3390/jof9060624
PMID: 37367560

11 p, 1.5 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Institut de Ciència i Tecnologia Ambientals (ICTA)
Articles > Research articles
Articles > Published articles