Dickkopf Proteins and Their Role in Cancer : A Family of Wnt Antagonists with a Dual Role
Giralt, Irina (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Gallo-Oller, Gabriel (Vall d'Hebron Institut d'Oncologia)
Navarro Barea, Natalia (Vall d'Hebron Institut d'Oncologia)
Zarzosa, Patricia (Vall d'Hebron Institut d'Oncologia)
Pons, Guillem (Vall d'Hebron Institut d'Oncologia)
Magdaleno, Ainara (Vall d'Hebron Institut d'Oncologia)
Segura, Miguel F. (Vall d'Hebron Institut d'Oncologia)
Sánchez de Toledo, Joan (Vall d'Hebron Institut d'Oncologia)
Moreno, Lucas (Hospital Universitari Vall d'Hebron)
Gallego, Soledad (Hospital Universitari Vall d'Hebron)
Roma, Josep (Vall d'Hebron Institut d'Oncologia)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	The Wnt signaling pathway regulates crucial aspects such as cell fate determination, cell polarity and organogenesis during embryonic development. Wnt pathway deregulation is a hallmark of several cancers such as lung, gastric and liver cancer, and has been reported to be altered in others. Despite the general agreement reached by the scientific community on the oncogenic potential of the central components of the pathway, the role of the antagonist proteins remains less clear. Deregulation of the pathway may be caused by overexpression or downregulation of a wide range of antagonist proteins. Although there is growing information related to function and regulation of Dickkopf (DKK) proteins, their pharmacological potential as cancer therapeutics still has not been fully developed. This review provides an update on the role of DKK proteins in cancer and possible potential as therapeutic targets for the treatment of cancer; available compounds in pre-clinical or clinical trials are also reviewed.
Grants:	Instituto de Salud Carlos III PI18/00398 Instituto de Salud Carlos III PI21/00640
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Dickkopf ; DKK ; Wnt antagonists ; Wnt signaling
Published in:	Pharmaceuticals, Vol. 14 (august 2021) , ISSN 1424-8247

DOI: 10.3390/ph14080810
PMID: 34451907

18 p, 1.4 MB

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