Impact of COVID-19 infection on cognition and its association with neurological symptoms
Almeria, Marta (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Cejudo, Juan Carlos (Hospital Sagrat Cor (Martorell))
Sanz-Santos, José (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Deus Yela, Juan (Universitat Autònoma de Barcelona. Departament de Medicina)
Krupinski, Jerzy (Healthcare sciences Manchester Metropolitan University)

Fecha:	2023
Resumen:	Objective: To characterize the cognitive profile following COVID-19 infection and its possible association to clinical symptoms, emotional disturbance, biomarkers, and disease severity. Methods: This was a single-center cross-sectional cohort study. Subjects between 20- and 60-year old with confirmed COVID-19 infection were included. Evaluation was performed between April 2020 and July 2021. Patients with previous cognitive impairment and other neurological or severe psychiatric disorders were excluded. Demographic and laboratory data were extracted from the medical records. Results: Altogether 200 patients were included, 85 subjects were female (42. 3%), and mean age was 49. 12 years (SD: 7. 84). Patients were classified into four groups: nonhospitalized (NH, n = 21), hospitalized without intensive care unit (ICU) nor oxygen therapy (HOSP, n = 42), hospitalized without ICU but with oxygen therapy (OXY, n = 107), and ICU (ICU, n = 31) patients. NH group was younger (p =. 026). No significant differences were found in any test performed attending severity of illness (p >. 05). A total of 55 patients reported subjective cognitive complaints (SCC). Subjects with neurological symptoms (NS) performed worse in trail making test B (p =. 013), digits backwards (p =. 006), letter&numbers (p =. 002), symbol digit modalities test (p =. 016), and Stroop color (p =. 010) tests. Conclusions: OXY patients and females referred more SCC associated with symptoms of anxiety and depression. Objective cognitive performance was unrelated to SCC. No cognitive impairment was found regarding the severity of COVID-19 infection. Results suggest that NS such as headache, anosmia, and dysgeusia during infection were a risk factor for later cognitive deficits. Tests assessing attention, processing speed, and executive function were the most sensitive in detecting cognitive changes in these patients.
Ayudas:	Instituto de Salud Carlos III PI17/02089 Generalitat de Catalunya 2019/SGR-1198
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Publicado en:	Brain and behavior, Vol. 13 Núm. 4 (april 2023) , p. e2902, ISSN 2162-3279

DOI: 10.1002/brb3.2902
PMID: 36811291

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