Effect of a Mediterranean Diet or Mindfulness-Based Stress Reduction During Pregnancy on Child Neurodevelopment
Crovetto, Francesca (Institut de Recerca Sant Joan de Déu)
Nakaki, Ayako (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Arranz, Angela (Hospital Sant Joan de Déu (Manresa))
Borràs, Roger (Hospital Clínic i Provincial de Barcelona)
Vellvé, Kilian (Hospital Sant Joan de Déu (Manresa))
Paules, Cristina (Hospital Sant Joan de Déu (Manresa))
Boutet, Maria Laura (Hospital Sant Joan de Déu (Manresa))
Castro-Barquero, Sara (Hospital Clínic i Provincial de Barcelona)
Freitas, Tania (Hospital Clínic i Provincial de Barcelona)
Casas, Rosa (Hospital Clínic i Provincial de Barcelona)
Martín-Asuero, Andrés (Instituto esMindfulness)
Oller Guzmán, Teresa (Instituto esMindfulness)
Morilla Figueras, Ivette (Hospital Clínic i Provincial de Barcelona)
Martínez-Àran, Anabel (Hospital Clínic i Provincial de Barcelona)
Camacho, Alba (Hospital Sant Joan de Déu (Manresa))
Pasqual, Mireia (Hospital Sant Joan de Déu (Manresa))
Izquierdo Renau, Montserrat (Hospital Sant Joan de Déu (Manresa))
Pozo, Oscar J (Institut Hospital del Mar d'Investigacions Mèdiques)
Gomez-Gomez, A. (Institut Hospital del Mar d'Investigacions Mèdiques)
Estruch, Ramón (Hospital Clínic i Provincial de Barcelona)
Vieta, Eduard (Hospital Clínic i Provincial de Barcelona)
Crispi, Fatima (Hospital Sant Joan de Déu (Manresa))
Gratacos, Eduard (Hospital Sant Joan de Déu (Manresa))
Universitat Autònoma de Barcelona

Fecha:	2023
Resumen:	Is a Mediterranean diet or mindfulness-based stress reduction intervention during pregnancy effective in improving child neurodevelopment at age 2 years? In this randomized clinical trial that included 626 children, Bayley-III scores were significantly higher in cognitive and social-emotional domains in the Mediterranean diet group and significantly higher in the social-emotional domain in the stress reduction group compared with the usual care group. Structured interventions during pregnancy based on a Mediterranean diet or mindfulness-based stress reduction significantly improved child neurodevelopment at 2 years. This prespecified analysis of a randomized clinical trial evaluates the effect of a Mediterranean diet or mindfulness-based stress reduction during pregnancy on child neurodevelopment at age 2 years. Maternal suboptimal nutrition and high stress levels are associated with adverse fetal and childhood neurodevelopment. To test the hypothesis that structured interventions based on a Mediterranean diet or mindfulness-based stress reduction (MBSR) during pregnancy improve child neurodevelopment at age 2 years. This was a prespecified analysis of the parallel-group Improving Mothers for a Better Prenatal Care Trial Barcelona (IMPACT BCN) randomized clinical trial, which was conducted at a university hospital in Barcelona, Spain, from February 2017 to March 2020. A total of 1221 singleton pregnancies (19 to 23 weeks' gestation) with high risk of delivering newborns who were small for gestational age were randomly allocated into 3 groups: a Mediterranean diet intervention, an MBSR program, or usual care. A postnatal evaluation with the Bayley Scales of Infant and Toddler Development, 3rd Edition (Bayley-III), was performed. Data were analyzed from July to November 2022. Participants in the Mediterranean diet group received monthly individual and group educational sessions and free provision of extra virgin olive oil and walnuts. Those in the stress reduction group underwent an 8-week MBSR program adapted for pregnancy. Individuals in the usual care group received pregnancy care per institutional protocols. Neurodevelopment in children was assessed by Bayley-III at 24 months of corrected postnatal age. A total of 626 children (293 [46. 8%] female and 333 [53. 2%] male) participated at a mean (SD) age of 24. 8 (2. 9) months. No differences were observed in the baseline characteristics between intervention groups. Compared with children from the usual care group, children in the Mediterranean diet group had higher scores in the cognitive domain (β, 5. 02; 95% CI, 1. 52-8. 53; P = . 005) and social-emotional domain (β, 5. 15; 95% CI, 1. 18-9. 12; P = . 01), whereas children from the stress reduction group had higher scores in the social-emotional domain (β, 4. 75; 95% CI, 0. 54-8. 85; P = . 02). In this prespecified analysis of a randomized clinical trial, maternal structured lifestyle interventions during pregnancy based on a Mediterranean diet or MBSR significantly improved child neurodevelopmental outcomes at age 2 years.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Publicado en:	JAMA network open, Vol. 6 (august 2023) , ISSN 2574-3805

DOI: 10.1001/jamanetworkopen.2023.30255
PMID: 37606923

22 p, 12.5 MB

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