Feline Morbillivirus : Clinical Relevance of a Widespread Endemic Viral Infection of Cats
Pennisi, Maria Grazia (University of Messina. Department of Veterinary Sciences)
Belák, Sándor (Swedish University of Agricultural Sciences. Department of Biomedical Sciences and Veterinary Public Health)
Tasker, Séverine (Linnaeus Veterinary Limited)
Addie, Diane D (Independent Researcher)
Boucraut-Baralon, Corine (Scanelis Laboratory)
Egberink, Herman (University of Utrecht. Department of Biomolecular Health Sciences)
Frymus, Tadeusz (Warsaw University of Life Sciences-SGWW. Department of Small Animal Diseases with Clinic)
Hartmann, Katrin (LMU Small Animal Clinic. Centre for Clinical Veterinary Medicine)
Hofmann-Lehmann, Regina (University of Zurich. Department of Clinical Diagnostics and Services)
Lloret Roca, Albert (Universitat Autònoma de Barcelona. Hospital Clínic Veterinari)
Marsilio, Fulvio (Università degli Studi di Teramo. Faculty of Veterinary Medicine)
Thiry, Etienne (Liège University. Department of Infectious and Parasitic Diseases)
Truyen, Uwe (University of Leipzig. Institute of Animal Hygiene and Veterinary Public Health)
Möstl, Karin (University of Veterinary Medicine. Department for Pathobiology)
Hosie, Margaret J (MRC-University of Glasgow Centre for Virus Research)

Fecha:	2023
Resumen:	Feline morbillivirus (FeMV) was first isolated in 2012 from stray cats in Hong Kong. It has been found in association with tubulointerstitial nephritis (TIN), the most common cause of feline chronic kidney disease (CKD). However, viral host spectrum and virus tropism go beyond the domestic cat and kidney tissues. The viral genetic diversity of FeMV is extensive, but it is not known if this is clinically relevant. Urine and kidney tissues have been widely tested in attempts to confirm associations between FeMV infection and renal disease, but samples from both healthy and sick cats can test positive and some cross-sectional studies have not found associations between FeMV infection and CKD. There is also evidence for acute kidney injury following infection with FeMV. The results of prevalence studies differ greatly depending on the population tested and methodologies used for detection, but worldwide distribution of FeMV has been shown. Experimental studies have confirmed previous field observations that higher viral loads are present in the urine compared to other tissues, and renal TIN lesions associated with FeMV antigen have been demonstrated, alongside virus lymphotropism and viraemia-associated lymphopenia. Longitudinal field studies have revealed persistent viral shedding in urine, although infection can be cleared spontaneously.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	FeMV ; Cat ; Urine ; CKD ; TIN ; Host spectrum ; Epidemiology ; Experimental infection ; Pathology ; Diagnosis
Publicado en:	Viruses, Vol. 15 (october 2023) , ISSN 1999-4915

DOI: 10.3390/v15102087
PMID: 37896864

19 p, 760.4 KB

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