Body weight gain and control : beneficial effect of extra virgin olive oil versus corn oil in an experimental model of mammary cancer
Moral Cabrera, Raquel (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Kapravelou, Garyfallia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Cubedo, Marta (Universitat de Barcelona. Departament d'Estadística)
Solanas, Montserrat (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Escrich, Eduard (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)

Date:	2024
Description:	11 pàg.
Abstract:	Obesity is a known risk factor for breast cancer, the most common malignancy among women worldwide. We have previously described different effects of high-fat diets on mammary experimental carcinogenesis. In this work, we analyzed the animal growth data obtained in six experimental assays, in healthy and carcinogen-induced rats undergoing different dietary interventions. The animals were fed with three experimental diets administered at different periods of development: a control low-fat diet, and two isocaloric high-fat diets (rich in corn oil or in extravirgin olive oil -EVOO-). Weekly weight throughout the development of 818 animals have been compiled and reanalyzed using adjusted mathematical models. Molecular mechanisms have been investigated: ethanolamides in small intestine, neuropeptides controlling satiety in hypothalamus, and proteins controlling lipid metabolism in adipose and mammary tissues. The results indicated that the effect of diets depended on type of lipid, timing of intervention and health status. The high corn oil diet, but not the high EVOO diet, increased body weight and mass, especially if administered from weaning, in healthy animals and in those that received a moderate dose of carcinogen. The potential protective effect of EVOO on weight maintenance may be related to anorexigenic neuropeptides such as oxytocin and lipolysis/deposition balance in adipose tissue (increasing phospho-PKA, HSL, MGL and decreasing FAS). In animals with cancer, body weight gain was related to the severity of the disease. Taken together, our results suggest that EVOO has a beneficial effect on body weight maintenance in both health and cancer.
Grants:	Ministerio de Educación y Ciencia AGL2006-07691 Ministerio de Educación y Ciencia AGL2011-24778
Note:	Altres ajuts: acords transformatius de la UAB
Note:	Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
Note:	Altres ajuts: Fundación Patrimonio Comunal Olivarero (FPCO) (FPCO2008-165.396; FPCO2013-CF611.084); Agencia para el Aceite de Oliva del Ministerio de Agricultura, Alimentación y Medio Ambiente (AAO2008-165.471); Organización Interprofesional del Aceite de Oliva Español (OIAOE) (OIP2009-CD165.646); Departaments de Salut i d'Agricultura, Alimentació i Acció Rural de la Generalitat de Catalunya (GC2010-165.000), FPCO and OIAOE (FPCO-OIP2016-CF614.087).
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Body weight ; Breast cancer ; Dietary lipids ; Extra virgin olive oil ; Lipolysis ; Molecular mechanisms ; SDG 3 - Good Health and Well-being
Published in:	The Journal of nutritional biochemistry, Vol. 125 (March 2024) , art. 109549, ISSN 1873-4847

DOI: 10.1016/j.jnutbio.2023.109549
PMID: 38104866

11 p, 2.2 MB

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