Genomic Scanning of Inbreeding Depression for Litter Size in Two Varieties of Iberian Pigs
Hervás Rivero, Carlos (Universidad de Zaragoza. Instituto Agroalimentario de Aragón)
Srihi, Houssemeddine (Universidad de Zaragoza. Instituto Agroalimentario de Aragón)
López Carbonell, David (Universidad de Zaragoza. Instituto Agroalimentario de Aragón)
Casellas Vidal, Joaquim (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Ibañez-Escriche, Noelia (Universitat Politècnica de València. Instituto Universitario de Ciencia y Tecnología Animal)
Negro, Sara (INGA FOOD S.A. Programa de Mejora Genética "Castua")
Varona, Luis (Universidad de Zaragoza. Instituto Agroalimentario de Aragón)

Date:	2023
Abstract:	Inbreeding depression is expected to be more pronounced in fitness-related traits, such as pig litter size. Recent studies have suggested that the genetic determinism of inbreeding depression may be heterogeneous across the genome. Therefore, the objective of this study was to conduct a genomic scan of the whole pig autosomal genome to detect the genomic regions that control inbreeding depression for litter size in two varieties of Iberian pigs (Entrepelado and Retinto). The datasets consisted of 2069 (338 sows) and 2028 (327 sows) records of litter size (Total Number Born and Number Born Alive) for the Entrepelado and Retinto varieties. All sows were genotyped using the Geneseek GGP PorcineHD 70 K chip. We employed the Unfavorable Haplotype Finder software to extract runs of homozygosity (ROHs) and conducted a mixed-model analysis to identify highly significant differences between homozygous and heterozygous sows for each specific ROH. A total of eight genomic regions located on SSC2, SSC5, SSC7, SSC8, and SSC13 were significantly associated with inbreeding depression, housing some relevant genes such as FSHR, LHCGR, CORIN, AQP6, and CEP120.
Grants:	Ministerio de Ciencia e Innovación CGL2016-80155-R Ministerio de Ciencia e Innovación PID2020-114705RB-I00 European Commission. Horizon 2020 801586
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Iberian pig ; Litter size ; Inbreeding depression
Published in:	Genes, Vol. 14 (october 2023) , ISSN 2073-4425

DOI: 10.3390/genes14101941
PMID: 37895290

11 p, 2.7 MB

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