Stabilization and Binding of [V4O12]4− and Unprecedented [V20O54(NO3)]n− to Lysozyme upon Loss of Ligands and Oxidation of the Potential Drug VIVO(acetylacetonato)2
Ferraro, Giarita (Università degli Studi di Napoli Federico II. Dipartimento di Scienze Chimiche)
Tito, Gabriella (Università degli Studi di Napoli Federico II. Dipartimento di Scienze Chimiche)
Sciortino, Giuseppe (Institut d'Investigacions Químiques de Catalunya)
Garribba, Eugenio (Università di Sassari. Dipartimento di Medicina, Chirurgia e Farmacia)
Merlino, Antonello (Università degli Studi di Napoli Federico II. Dipartimento di Scienze Chimiche)

Date:	2023
Abstract:	High-resolution crystal structures of lysozyme in the presence of the potential drug VIVO(acetylacetonato)2 under two different experimental conditions have been solved. The crystallographic study reveals the loss of the ligands, the oxidation of VIV to VV and the subsequent formation of adducts of the protein with two different polyoxidovanadates: [V4O12]4−, which interacts with lysozyme non-covalently, and the unprecedented [V20O54(NO3)]n−, which is covalenty bound to the side chain of an aspartate residue of symmetry related molecules.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Lysozyme ; Polyhedra ; Polyoxidovanadates ; Protein Interaction ; Vanadium ; Vanadium-Based Drugs
Published in:	Angewandte Chemie (International ed. Internet), Vol. 62, Issue 50 (December 2023) , art. e202310655, ISSN 1521-3773

DOI: 10.1002/anie.202310655
PMID: 37768728

5 p, 1.6 MB

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