Fat digestibility is reduced in old cats with subnormal cobalamin concentrations
Salas, Anna (Affinity Pet Care)
Manuelian, Carmen L (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Garganté, Marta (Affinity Pet Care)
Sanchez, Núria (Affinity Pet Care)
Fernández, Sonia (Doc's Veterinary Clinic)
Compagnucci, Marco (Affinity Pet Care)
Cerón, José Joaquín (Universidad de Murcia. Departamento de Cirugía y Medicina Animal)
Jeusette, Isabelle (Affinity Pet Care)
Vilaseca, Lluís (Affinity Pet Care)
Torre, Celina (Affinity Pet Care)

Fecha:	2014
Resumen:	Fat digestibility is decreased in old cats for unknown reasons. Subclinical gastrointestinal diseases and pancreatic dysfunction, both related to ageing, can affect food digestibility. The aim of the present study was to elucidate the prevalence of subnormal cobalamin concentration and pancreatic disease in old cats and study the relationship between both markers and fat digestibility. A total of sixty-four cats without evident signs of gastrointestinal disease were included and grouped according to age: (1) fifteen middle-aged (MA), aged 3-7 years; and (2) forty-nine old, aged 10-17 years. All cats were tested for serum cobalamin, specific feline pancreatic lipase (fPL) and feline trypsin-like immunoreactivity. Then, sixteen of the old cats were selected and grouped according to cobalamin and fPL concentrations: control (normal cobalamin and fPL); low vitamin B12 (cobalamin <290 ng/l; normal fPL); and high fPL (normal cobalamin; fPL >4 µg/ml). A food digestibility trial with a high-fat diet (21·6 %) was performed. In the old group, cobalamin was lower and fPL higher than in MA cats. Of the old cats (n 49), 14 % had subnormal cobalamin, 8 % had a severe increase in fPL, 2 % had both alterations and 14 % had a slight increase in fPL. By contrast, MA cats did not have cobalamin deficiency or an increase in fPL concentrations. Fat digestibility was lower in low vitamin B12 cats than control cats. Decreased fat digestibility is not present in all old cats but could be a characteristic of subclinical chronic gastrointestinal disease. Cobalamin concentration, as a marker of gastrointestinal disease, could be useful for the routine evaluation of old cats.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Feline nutrition ; Cobalamin ; Ageing ; Digestibility
Publicado en:	Journal of nutritional science, ISSN 2048-6790

DOI: 10.1017/jns.2014.59
PMID: 26101630

5 p, 301.2 KB

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