On equivalence and bioequivalence testing
Ocaña, Jordi (Universitat de Barcelona)
Sánchez, M. Pilar (Universidad de Chile)
Sánchez, Álex (Universitat de Barcelona)
Carrasco, Josep Lluís (Universitat de Barcelona)

Date:	2008
Abstract:	Equivalence testing is the natural approach to many statistical problems. First, its main application, bioequivalence testing, is reviewed. The basic concepts of bioequivalence testing (2×2 crossover designs, TOST, interval inclusion principle, etc. ) and its problems (TOST biased character, the carryover problem, etc. ) are considered. Next, equivalence testing is discussed more generally. Some applications and methods are reviewed and the relation of equivalence testing and distance-based inference is highlighted. A new distance-based method to determine whether two gene lists are equivalent in terms of their annotations in the Gene Ontology illustrates these ideas. We end with a general discussion and some suggestions for future research.
Rights:	Tots els drets reservats
Language:	Anglès
Form:	article ; publishedVersion
Subject:	Crossover designs ; TOST ; Intersection-union ; Distance-based inference ; Validation of simulation models ; Gene Ontology
Published in:	SORT : statistics and operations research transactions, Vol. 32, Núm. 2 (July-December 2008) , p. 151-176, ISSN 1696-2281

26 p, 533.1 KB  Accés restringit a la UAB

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