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17 p, 367.8 KB |
New Antibiotics for Staphylococcus aureus Infection : An Update from the World Association of Infectious Diseases and Immunological Disorders (WAidid) and the Italian Society of Anti-Infective Therapy (SITA)
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Esposito, Susanna (Pediatric Clinic. Pietro Barilla Children's Hospital. Department of Medicine and Surgery. University Hospital of Parma) ;
Blasi, Francesco (Ca' Granda Ospedale Maggiore Policlinico Milano) ;
Curtis, Nigel (Department of Infectious Diseases. The Royal Children's Hospital Melbourne) ;
Kaplan, Sheldon (Division of Infectious Diseases. Department of Pediatrics. Baylor College of Medicine) ;
Lazzarotto, Tiziana (IRCCS Azienda Ospedaliero-Universitaria di Bologna) ;
Meschiari, Marianna (Azienda Ospedaliero-Universitaria of Modena) ;
Mussini, Cristina (Azienda Ospedaliero-Universitaria of Modena) ;
Peghin, Maddalena (Infectious and Tropical Diseases Unit. Department of Medicine and Surgery. University of Insubria-ASST-Sette Laghi) ;
Rodrigo Gonzalo de Líria, Carlos (Institut Germans Trias i Pujol) ;
Vena, Antonio (IRCCS Ospedale Policlinico San Martino) ;
Principi, Nicola (Università degli Studi di Milano) ;
Bassetti, Matteo (IRCCS Ospedale Policlinico San Martino) ;
Universitat Autònoma de Barcelona.
Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública
Staphylococcus aureus is an extremely virulent pathogen that is capable of quickly evolving and developing antibiotic resistance. To overcome this problem, new antibiotics have been developed. Some of these have been licenced for use in clinical practice, mainly for the treatment of adults with acute skin and soft tissue infections, in addition to both community-acquired pneumonia (CAP) and nosocomial pneumonia (hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia). [...]
2023 -  10.3390/antibiotics12040742
Antibiotics, Vol. 12 Núm. 4 (april 2023) , art. 742
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13 p, 993.7 KB |
Advances in antibiotic therapy in the critically ill
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Vincent, Jean-Louis (Université libre de Bruxelles) ;
Bassetti, Matteo (Santa Maria Misericordia University Hospital) ;
François, Bruno (Service de Réanimation Polyvalente (França)) ;
Karam, George (Louisiana State University School of Medicine (Estats Units d'Amèrica)) ;
Chastre, Jean (Groupe Hospitalier Pitié-Salpêtrière) ;
Torres, Antoni (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Roberts, Jason A. (The University of Queensland) ;
Taccone, Fabio Silvio (Université libre de Bruxelles) ;
Rello, Jordi (Hospital Universitari Vall d'Hebron) ;
Calandra, Thierry (University of Lausanne) ;
De Backer, Daniel (Université Libre de Bruxelles) ;
Welte, Tobias (Medizinische Hochschule) ;
Antonelli, Massimo (Catholic University of Rome) ;
Universitat Autònoma de Barcelona
Infections occur frequently in critically ill patients and their management can be challenging for various reasons, including delayed diagnosis, difficulties identifying causative microorganisms, and the high prevalence of antibiotic-resistant strains. [...]
2016 - 10.1186/s13054-016-1285-6
Critical Care, Vol. 20 (may 2016)
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3.
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5 p, 732.0 KB |
Intensive care unit patients with lower respiratory tract nosocomial infections : the ENIRRIs project
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De Pascale, Gennaro (Università Cattolica del Sacro Cuore) ;
Ranzani, Otavio T. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Nseir, Saad (CHU Lille) ;
Chastre, Jean (Groupe Hospitalier Pitié-Salpêtrière) ;
Welte, Tobias (Hannover Medical School) ;
Antonelli, Massimo (Università Cattolica del Sacro Cuore) ;
Navalesi, Paolo (Università della Magna Graecia) ;
Garofalo, Eugenio (Università della Magna Graecia) ;
Bruni, Andrea (Università della Magna Graecia) ;
Coelho, Luis (New University of Lisbon) ;
Skoczynski, Szymon (Medical University of Silesia) ;
Longhini, Federico (Sant'Andrea Hospital) ;
Taccone, Fabio Silvio (Université Libre de Bruxelles) ;
Grimaldi, David (Université Libre de Bruxelles) ;
Salzer, Helmut J. F. (University of Lübeck) ;
Lange, Christoph (University of Lübeck) ;
Froes, Filipe (Hospital Pulido Valente) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Díaz-Aparicio, Efren (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Vallés, Jordi (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Rodríguez, Alejandro (Hospital Universitari Joan XXIII de Tarragona) ;
Panigada, Mauro (Ospedale Maggiore Policlinico) ;
Comellini, Vittoria (Alma Mater University) ;
Fasano, Luca (Alma Mater University) ;
Soave, Paolo M. (Università Cattolica del Sacro Cuore) ;
Spinazzola, Giorgia (Università Cattolica del Sacro Cuore) ;
Luyt, Charles-Edouard (Groupe Hospitalier Pitié-Salpêtrière) ;
Álvarez Lerma, Francisco (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Marin, Judith (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Masclans, Joan R (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Chiumello, Davide (Università degli Studi di Milano) ;
Pezzi, Angelo (Università degli Studi di Milano) ;
Schultz, Marcus (Mahidol University) ;
Mohamed, Hafiz (St. James's Hospital (Irlanda)) ;
Van Der Eerden, Menno (Erasmus MC (Rotterdam)) ;
Hoek, Roger A. S. (Erasmus MC (Rotterdam)) ;
Gommers, D. A. M. P. J. (Erasmus MC (Rotterdam)) ;
Pasquale, Marta Di (IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico) ;
Civljak, Rok (University of Zagreb School of Medicine) ;
Kutleša, Marko (University of Zagreb School of Medicine) ;
Bassetti, Matteo (Medicine University of Udine and Santa aria Misericordia Hospital) ;
Dimopoulos, George (University General Hospital Attikon (Haidari, Grècia)) ;
Nava, Stefano (Alma Mater University) ;
Rios, Fernando (Hospital Nacional Profesor A Posadas (Argentina)) ;
Zampieri, Fernando G. (Hospital do Coração (Brasil)) ;
Povoa, Pedro (New University of Lisbon) ;
Bos, Lieuwe D.. (Academic Medical Center (Holanda)) ;
Aliberti, Stefano (IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico) ;
Torres, Antoni (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Martín-Loeches, Ignacio (St. James's Hospital (Irlanda)) ;
Universitat Autònoma de Barcelona
The clinical course of intensive care unit (ICU) patients may be complicated by a large spectrum of lower respiratory tract infections (LRTI), defined by specific epidemiological, clinical and microbiological aspects. [...]
2017 - 10.1183/23120541.00092-2017
ERJ Open Research, Vol. 3 (november 2017)
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9 p, 408.2 KB |
Factors associated with the development of septic shock in patients with candidemia : a post hoc analysis from two prospective cohorts
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Bassetti, Matteo (University of Udine and Azienda Sanitaria) ;
Vena, Antonio (Clinica Malattie Infettive) ;
Meroi, Marco (University of Udine and Azienda Sanitaria Universitaria Integrata) ;
Cardozo, Celia (Hospital Clínic i Provincial de Barcelona) ;
Cuervo, Guillermo (Hospital Universitari de Bellvitge) ;
Giacobbe, Daniele Roberto (Clinica Malattie Infettive) ;
Salavert, Miguel (Hospital Universitari i Politècnic La Fe (València)) ;
Merino, Paloma (Hospital Clínico San Carlos (Madrid)) ;
Gioia, Francesca (Hospital Universitario Ramón y Cajal (Madrid)) ;
Fernández-Ruiz, Mario (Hospital Universitario 12 de Octubre (Madrid)) ;
López-Cortés, Luis Eduardo (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Almirante Gragera, Benito (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Escolà-Vergé, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montejo, Miguel (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Aguilar-Guisado, Manuela (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Puerta-Alcalde, Pedro (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Tasias, Mariona (Hospital Universitari i Politècnic La Fe (València)) ;
Ruiz-Gaitán, Alba (Hospital Universitari i Politècnic La Fe (València)) ;
González, Fernando (Hospital Clínico San Carlos (Madrid)) ;
Puig-Asensio, Mireia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Marco, Francesc (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Pemán, Javier (Hospital Universitari i Politècnic La Fe (València)) ;
Fortún, Jesús (Hospital Universitario Ramón y Cajal (Madrid)) ;
Aguado, José María (Hospital Universitario 12 de Octubre (Madrid)) ;
Soriano, Alejandro (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Carratalà, Jordi (Institut d'Investigació Biomèdica de Bellvitge) ;
Garcia-Vidal, Carolina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Valerio, Maricela (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Sartor, Assunta (Microbiology Unit, Azienda Sanitaria Universitaria Integrata Santa Maria della Misericordia) ;
Bouza, Emilio (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Muñoz, Patricia (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Universitat Autònoma de Barcelona
Almost one third of the patients with candidemia develop septic shock. The understanding why some patients do and others do not develop septic shock is very limited. The objective of this study was to identify variables associated with septic shock development in a large population of patients with candidemia. [...]
2020 - 10.1186/s13054-020-2793-y
Critical Care, Vol. 24 (march 2020)
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13 p, 606.0 KB |
Comparison of the Safety and Tolerance Profile of Micafungin with that of Other Echinocandins and Azoles in Patients with Pre-existing Child-Pugh B or C Liver Disease : A Case-Control Retrospective Study
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Vena, Antonio (Hospital General Universitario Gregorio Marañón) ;
Bouza, Emilio (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Bassetti, Matteo (University of Udine) ;
Menichetti, Francesco (Nuovo Santa Chiara University Hospital) ;
Merelli, Maria (University of Udine) ;
Grau, Santiago (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Fortún, Jesús (Hospital Universitario Ramón y Cajal (Madrid)) ;
Sánchez, María Isabel (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Aguado, José María (Universidad Complutense de Madrid) ;
Merino, Paloma (Hospital Clínico San Carlos (Madrid)) ;
Bonache, Francisco (Hospital General Universitario Gregorio Marañón) ;
Muñoz, Patricia (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM))
To assess the association between exposure to micafungin, other echinocandins, or azoles and the development of short-term liver injury (STLI) or long-term liver injury (LTLI) in patients with Child-Pugh B or C liver disease. [...]
2020 - 10.1007/s40121-020-00282-w
Infectious Diseases and Therapy, Vol. 9 (february 2020) , p. 151-163
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9 p, 1.7 MB |
Economic analysis of ceftaroline fosamil for treating community-acquired pneumonia in Spain
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Torres, Antoni (Hospital Clínic i Provincial de Barcelona) ;
Bassetti, Matteo (Santa Maria della Misericordia University Hospital, Udine) ;
Welte, Tobias (Medizinische Hochschule Hannover) ;
Rivolo, Simone (Evidera, London) ;
Remak, Edit (Evidera, Budapest) ;
Peral, Carmen (Pfizer, Madrid) ;
Charbonneau, Claudie (Pfizer, Paris) ;
Hammond, Jennifer (Pfizer, Collegeville, PA, USA) ;
Ansari, Wajeeha (Pfizer, New York) ;
Grau, Santiago (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Background: Adults admitted to hospital with community-acquired pneumonia (CAP) impose significant burden upon limited hospital resources. To achieve early response and possibly early discharge, thus reducing hospital expenditure, the choice of initial antibiotic therapy is pivotal. [...]
2020 - 10.1080/13696998.2019.1688819
Journal of Medical Economics, Vol. 23 Núm. 2 (january 2020) , p. 148-155
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7 p, 474.6 KB |
Pharmacokinetic variability and exposures of fluconazole, anidulafungin, and caspofungin in intensive care unit patients : Data from multinational Defining Antibiotic Levels in Intensive care unit (DALI) patients Study
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Sinnollareddy, Mahipal G. (The Queen Elizabeth Hospital. Basil Hetzel Institute for Translational Health Research) ;
Roberts, Jason A. (Royal Brisbane and Women's Hospital) ;
Lipman, Jeffrey (Royal Brisbane and Women's Hospital) ;
Akova, Murat (Hacettepe University, Ankara) ;
Bassetti, Matteo (Azienda Ospedaliera Universitaria Santa Maria della Misericordia) ;
De Waele, Jan J. (Universitair Ziekenhuis Gent) ;
Kaukonen, Kirsi-Maija (Helsinki University Central Hospital) ;
Koulenti, Despoina (University General Hospital Attikon (Haidari, Grècia)) ;
Martin, Claude (AzuRea Group, Antibes, France) ;
Montravers, Philippe (Centre Hospitalier Universitaire Bichat-Claude Bernard) ;
Rello, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rhodes, Andrew (St George's Healthcare NHS Trust and St George's University of London) ;
Starr, Therese (Royal Brisbane and Women's Hospital) ;
Wallis, Steven C. (The University of Queensland) ;
Dimopoulos, George (University General Hospital Attikon (Haidari, Grècia)) ;
Universitat Autònoma de Barcelona
The objective of the study was to describe the pharmacokinetics (PK) of fluconazole, anidulafungin, and caspofungin in critically ill patients and to compare with previously published data. We also sought to determine whether contemporary fluconazole doses achieved PK/pharmacodynamic (PD; PK/PD) targets in this cohort of intensive care unit patients. [...]
2015 - 10.1186/s13054-015-0758-3
Critical Care, Vol. 19 (february 2015)
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