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9 p, 1.6 MB |
Effectiveness and safety of anti-CGRP monoclonal antibodies in patients over 65 years : a real-life multicentre analysis of 162 patients
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Muñoz-Vendrell, Albert (Hospital Universitari de Bellvitge) ;
Campoy Diaz, Sergio (Hospital Universitari de Bellvitge) ;
Caronna, Edoardo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alpuente, Alicia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Torres-Ferrús, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nieves Castellanos, Candela (Hospital Universitari I Politécnic La Fe) ;
Olivier, Marina (Hospital Universitari I Politécnic La Fe) ;
Campdelacreu, Jaume (Hospital Universitari de Bellvitge) ;
Prat, Joan (Hospital Universitari de Bellvitge) ;
Camiña Muñiz, Javier (Clínica Rotger Quirónsalud) ;
Molina Martínez, Francisco José (Hospital Universitari Son Espases) ;
Mínguez-Olaondo, Ane (Instituto de Investigación Sanitaria Biodonostia) ;
Ruibal Salgado, Marta (Instituto de Investigación Sanitaria Biodonostia) ;
Santos Lasaosa, Sonia (Hospital Clínico Universitario Lozano Blesa) ;
Navarro Pérez, María Pilar (Hospital Clínico Universitario Lozano Blesa) ;
Morollón, Noemí (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
López Bravo, Alba (Hospital Reina Sofía) ;
Cano Sánchez, Luis Miguel (Hospital Sant Joan Despí) ;
García-Sánchez, Sonia María (Hospital Sant Joan Despí) ;
García-Ull, Jésica (Hospital Clínico Universitario de Valencia) ;
Rubio-Flores, Laura (Hospital Universitario General de Villalba) ;
Gonzalez-Martinez, Alicia (Hospital Universitario de La Princesa E Instituto de Investigación Sanitaria Princesa) ;
Quintas, Sonia (Hospital Universitario de La Princesa E Instituto de Investigación Sanitaria Princesa) ;
Echavarría Íñiguez, Ana (Hospital Clínico Universitario de Valladolid) ;
Gil Luque, Sendoa (Hospital Universitario de Burgos) ;
Castro-Sánchez, María Victoria (Hospital Carlos Haya de Málaga) ;
Adell Ortega, Vanesa (Consorci Sanitari de L'Alt Penedès-Garraf) ;
García Alhama, Jessica (Consorci Sanitari de L'Alt Penedès-Garraf) ;
Berrocal-Izquierdo, Nuria (Parc Sanitari Sant Joan de Déu) ;
Belvís Nieto, Roberto (Institut d'Investigació Biomèdica Sant Pau) ;
Díaz-Insa, Samuel (Hospital Universitari I Politécnic La Fe) ;
Pozo-Rosich, Patricia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Huerta Villanueva, Mariano (Hospital Universitari de Bellvitge) ;
Universitat Autònoma de Barcelona
Anti-CGRP monoclonal antibodies have shown notable effectiveness and tolerability in migraine patients; however, data on their use in elderly patients is still lacking, as clinical trials have implicit age restrictions and real-world evidence is scarce. [...]
2023 -  10.1186/s10194-023-01585-2
Journal of headache and pain, Vol. 24 (june 2023)
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2.
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7 p, 663.7 KB |
Common and rare TBK1 variants in early-onset Alzheimer disease in a European cohort
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Verheijen, Jan (University of Antwerp) ;
van der Zee, Julie (University of Antwerp) ;
Gijselinck, Ilse (University of Antwerp) ;
Van den Bossche, Tobi (University Hospital Antwerp (Bèlgica)) ;
Dillen, Lubina (University of Antwerp) ;
Heeman, Bavo (University of Antwerp) ;
Gómez-Tortosa, Estrella (Hospital Universitario Fundación Jiménez Díaz) ;
Lladó, Albert (Hospital Clínic i Provincial de Barcelona) ;
Sanchez-Valle, Raquel (Hospital Clínic i Provincial de Barcelona) ;
Graff, Caroline (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Pastor, Pau (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Pastor, Maria A. (Clínica Universidad de Navarra) ;
Benussi, Luisa (Istituto Centro San Giovanni di Dio-Fatebenefratelli) ;
Ghidoni, Roberta (Istituto Centro San Giovanni di Dio-Fatebenefratelli) ;
Binetti, Giuliano (Istituto Centro San Giovanni di Dio-Fatebenefratelli) ;
Clarimón, Jordi (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
de Mendonça, Alexandre (University of Lisbon) ;
Gelpi, Ellen (Hospital Clínic i Provincial de Barcelona) ;
Tsolaki, Magda (Aristotle University of Thessaloniki) ;
Diehl-Schmid, Janine (Technische Universität München) ;
Nacmias, Benedetta (University of Florence) ;
Almeida, Maria Rosário (University of Coimbra) ;
Borroni, Barbara (University of Brescia) ;
Matej, Radoslav (Thomayer Hospital in Prague) ;
Ruiz, Agustín (Fundació ACE) ;
Engelborghs, Sebastiaan (University Hospital Antwerp (Bèlgica)) ;
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ;
De Deyn, Peter P. (University Hospital Antwerp (Bèlgica)) ;
Cruts, Marc (University of Antwerp) ;
Van Broeckhoven, Christine (University of Antwerp) ;
Sleegers, Kristel (University of Antwerp) ;
Goeman, Johan ;
Nuytten, Dirk ;
Vandenbulcke, Mathieu ;
Santens, Patrick 700 1_ ;
Sieben, Anne ;
Dermaut, Bart ;
Versijpt, Jan ;
Michotte, Alex ;
Deryck, Olivier ;
Bergmans, Bruno ;
Willems, Christiana ;
Ivanoiu, Adrian ;
Salmon, Eric ;
Alexopoulos, Panagiotis (Technische Universität München) ;
Sorbi, Sandro ;
Bessi, Valentina ;
Bagnoli, Silvia ;
Santana, Isabel ;
Simões do Couto, Frederico ;
Martins, Madalena ;
Thonberg, Häkan ;
Fratiglioni, Laura ;
Padovani, Alessandro ;
Rohan, Zdenek ;
Razquin, Cristina ;
Lorenzo, Elena ;
Iglesias, Elena ;
Seijo-Martínez, Manuel ;
Rene, Ramon ;
Gascon, Jordi ;
Campdelacreu, Jaume ;
Koutroumani, Maria ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
TANK-binding kinase 1 (TBK1) loss-of-function (LoF) mutations are known to cause frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), often combined with memory deficits early in the disease course. [...]
2018 - 10.1016/j.neurobiolaging.2017.10.012
Neurobiology of Aging, Vol. 62 (february 2018) , p. 245.e1-245.e7
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10 p, 841.1 KB |
Efficacy and safety clinical trial with efavirenz in patients diagnosed with adult Niemann-pick type C with cognitive impairment
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Gascon-Bayarri, Jordi (Hospital Universitari de Bellvitge) ;
Simon, Petru Cristian (Hospital Universitari de Bellvitge) ;
Llop, Roser (Hospital Universitari de Bellvitge) ;
Carnaval, Thiago (Hospital Universitari de Bellvitge) ;
Ledesma, María Dolores (Centro de Biología Molecular Severo Ochoa) ;
Rico, Imma (Hospital Universitari de Bellvitge) ;
Sánchez-Castañeda, Cristina (Hospital Universitari de Bellvitge) ;
Campdelacreu, Jaume (Hospital Universitari de Bellvitge) ;
Calvo-Malvar, Nahum (Hospital Universitari de Bellvitge) ;
Cos, Mònica (Hospital Universitari de Bellvitge) ;
de Lama, Eugenia (Hospital Universitari de Bellvitge) ;
Cortés-Romera, Montserrat (Hospital Universitari de Bellvitge) ;
Rodríguez-Bel, Laura (Hospital Universitari de Bellvitge) ;
Pérez-Sousa, Celia (Complejo Hospitalario Universitario de A Coruña) ;
Cerdán Sánchez, María (Hospital General Universitario Santa María del Rosell) ;
Muelas, Nuria (Hospital Universitari i Politècnic La Fe (València)) ;
Sevillano, María Dolores (Hospital Universitario de Salamanca) ;
Mir, Pablo (Universidad de Sevilla) ;
López de Munain, Adolfo (Hospital de Donostia (Sant Sebastià, País Basc)) ;
Ferrer, Anna (Hospital Universitari de Bellvitge) ;
Videla, Sebastián (Hospital Universitari de Bellvitge) ;
Universitat Autònoma de Barcelona
Niemann-Pick disease Type C (NPC) is a genetic, incurable, neurodegenerative disorder. This orphan disease is most frequently caused by mutations in the NPC1 protein, resulting in intralysossomal cholesterol accumulation. [...]
2022 - 10.1097/MD.0000000000031471
Medicine, Vol. 101 (december 2022)
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12 p, 592.9 KB |
Glucocerebrosidase mRNA is Diminished in Brain of Lewy Body Diseases and Changes with Disease Progression in Blood
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Pérez-Roca, Laia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Adame Castillo, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Campdelacreu, Jaume (Hospital Universitari de Bellvitge) ;
Ispierto, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Vilas, Dolores (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rene, Ramon (Hospital Universitari de Bellvitge) ;
Álvarez, Ramiro (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gascon-Bayarri, Jordi (Hospital Universitari de Bellvitge) ;
Serrano-Munoz, Maria A. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ariza Fernández, A.. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Beyer, Katrin (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Parkinson disease (PD) and dementia with Lewy bodies (DLB) are Lewy body diseases characterized by abnormal alpha-synuclein deposits and overlapping pathological features in the brain. Several studies have shown that glucocerebrosidase (GBA) deficiency is involved in the development of LB diseases. [...]
2018 - 10.14336/AD.2017.0505
Aging and Disease, Vol. 9 (april 2018) , p. 208-219
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15 p, 2.7 MB |
Expression Levels of an Alpha-Synuclein Transcript in Blood May Distinguish between Early Dementia with Lewy Bodies and Parkinson's Disease
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Marsal-García, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Campdelacreu, Jaume (Hospital Universitari de Bellvitge) ;
Vilas, Dolores (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ispierto, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gascon-Bayarri, Jordi (Hospital Universitari de Bellvitge) ;
Reñé, Ramón (Hospital Universitari de Bellvitge) ;
Álvarez, Ramiro (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Beyer, Katrin (Institut Germans Trias i Pujol) ;
Urbizu, Aintzane (Institut Germans Trias i Pujol) ;
Arnaldo, Laura (Institut Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Lewy body diseases (LBD) including dementia with Lewy bodies (DLB) and Parkinson disease (PD) are characterized by alpha-synuclein pathology. DLB is difficult to diagnose and peripheral biomarkers are urgently needed. [...]
2021 - 10.3390/ijms22020725
International journal of molecular sciences, Vol. 22 Núm. 2 (2021) , p. 725
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17 p, 1.4 MB |
Exploratory study on microRNA profiles from plasma-derived extracellular vesicles in Alzheimer's disease and dementia with Lewy bodies
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Gámez-Valero, Ana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Campdelacreu, Jaume (Hospital Universitari de Bellvitge) ;
Vilas, Dolores (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ispierto, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Reñé, Ramón (Hospital Universitari de Bellvitge) ;
Álvarez, Ramiro (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Armengol Barnils, Maria del Pilar (Institut Germans Trias i Pujol) ;
Borràs i Serres, Francesc Enric (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Beyer, Katrin (Institut Germans Trias i Pujol)
Because of the increasing life expectancy in our society, aging-related neurodegenerative disorders are one of the main issues in global health. Most of these diseases are characterized by the deposition of misfolded proteins and a progressive cognitive decline. [...]
2019 - 10.1186/s40035-019-0169-5
Translational Neurodegeneration, Vol. 8 (october 2019)
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7.
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13 p, 3.2 MB |
Comprehensive proteomic profiling of plasma-derived Extracellular Vesicles from dementia with Lewy Bodies patients
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Gámez-Valero, Ana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Campdelacreu, Jaume (Hospital Universitari de Bellvitge) ;
Reñé, Ramón (Hospital Universitari de Bellvitge) ;
Beyer, Katrin (Institut Germans Trias i Pujol) ;
Borràs i Serres, Francesc Enric (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Proteins and nucleic acids contained in extracellular vesicles (EVs) are considered a feasible source of putative biomarkers for physiological and pathological conditions. Within the nervous system, not only neurons but also other brain cells are able to produce EVs, which have been involved in their physiological processes and also in the development and course of several neurodegenerative diseases. [...]
2019 - 10.1038/s41598-019-49668-y
Scientific reports, Vol. 9 (September 2019) , art. 13282
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