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7 p, 480.5 KB |
Cord Blood Units with High CD3+ Cell Counts Predict Early Lymphocyte Recovery After In Vivo T Cell-Depleted Single Cord Blood Transplantation
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Castillo, N. (Banc de Sang i Teixits) ;
Garcia Cadenas, Irene (Institut d'Investigació Biomèdica Sant Pau) ;
Díaz de Heredia, Cristina (Hospital Universitari Vall d'Hebron) ;
Martino Bofarull, Rodrigo (Institut d'Investigació Biomèdica Sant Pau) ;
Barba, Pere (Hospital Universitari Vall d'Hebron) ;
Ferrá, Christelle (Institut Català d'Oncologia) ;
Canals, Carme (Banc de Sang i Teixits) ;
Elorza, Izaskun (Hospital Universitari Vall d'Hebron) ;
Olivé, Teresa (Hospital Universitari Vall d'Hebron) ;
Badell Serra, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Malouf Sierra, Jorge 1971- (Institut d'Investigació Biomèdica Sant Pau) ;
Valcárcel, David (Hospital Universitari Vall d'Hebron) ;
Querol, Sergio (Banc de Sang i Teixits) ;
Universitat Autònoma de Barcelona
Although high absolute lymphocyte count (ALC) early after transplantation is a simple surrogate for immune reconstitution, few studies to date have established the predictive factors for ALC after umbilical cord blood transplantation (UCBT). [...]
2016 -  10.1016/j.bbmt.2016.03.009
Biology of blood and marrow transplantation, Vol. 22 Núm. 6 (january 2016) , p. 1073-1079
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7 p, 732.4 KB |
Early and Long-Term Impaired T Lymphocyte Immune Reconstitution after Cord Blood Transplantation with Antithymocyte Globulin
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Castillo, Nerea (Banc de Sang i Teixits) ;
Garcia Cadenas, Irene (Institut d'Investigació Biomèdica Sant Pau) ;
Barba, Pere (Hospital Universitari Vall d'Hebron) ;
Canals, Carme (Banc de Sang i Teixits) ;
Díaz de Heredia, Cristina (Hospital Universitari Vall d'Hebron) ;
Martino Bofarull, Rodrigo (Institut d'Investigació Biomèdica Sant Pau) ;
Ferrá, Christelle (Institut Català d'Oncologia) ;
Badell Serra, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Elorza, Izaskun (Hospital Universitari Vall d'Hebron) ;
Malouf Sierra, Jorge 1971- (Institut d'Investigació Biomèdica Sant Pau) ;
Valcárcel, David (Hospital Universitari Vall d'Hebron) ;
Querol, Sergio (Banc de Sang i Teixits) ;
Universitat Autònoma de Barcelona
Immune reconstitution is crucial to the success of allogeneic hematopoietic stem cell transplantation. Umbilical cord blood transplantation (UCBT) has been associated with delayed immune reconstitution. [...]
2017 - 10.1016/j.bbmt.2016.11.014
Biology of blood and marrow transplantation, Vol. 23 Núm. 3 (january 2017) , p. 491-497
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3.
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8 p, 1.2 MB |
Unexpected High Incidence of Human Herpesvirus-6 Encephalitis after Naive T Cell-Depleted Graft of Haploidentical Stem Cell Transplantation in Pediatric Patients
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Sisinni, Luisa (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Gasior, Mercedes (Hospital Universitario La Paz (Madrid)) ;
de Paz, Raquel (Hospital Universitario La Paz (Madrid)) ;
Querol, Sergio (Centre Frederic Duran i Jordà) ;
Bueno, David (Hospital Universitario La Paz (Madrid)) ;
Fernández, Lucía (Centro Nacional de Investigaciones Oncológicas) ;
Marsal, Julia (Sant Joan de Déu Hospital) ;
Sastre, Ana (Hospital Universitario La Paz (Madrid)) ;
Gimeno, Ramón (Hospital del Mar (Barcelona, Catalunya)) ;
Alonso, Laura (Hospital Universitari Vall d'Hebron) ;
Badell Serra, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
López-Granados, Eduardo (Hospital Universitario La Paz (Madrid)) ;
Torres, Juan (Hospital Universitario La Paz (Madrid)) ;
Medina, Laura (Centre Frederic Duran i Jordà) ;
Torrent, Montse (Institut d'Investigació Biomèdica Sant Pau) ;
Díaz de Heredia, Cristina (Hospital Universitari Vall d'Hebron) ;
Escudero, Adela (Hospital Universitario La Paz (Madrid)) ;
Pérez-Martínez, Antonio (Hospital Universitario La Paz (Madrid)) ;
Universitat Autònoma de Barcelona
The CD45RA T cell depletion (TCD) method has been used to deplete naive T cells, preventing graft-versus-host disease (GVHD) but preserving memory cells, providing immediate functional T cells with anti-infection, antileukemia, and antirejection effects. [...]
2018 - 10.1016/j.bbmt.2018.07.016
Biology of blood and marrow transplantation, Vol. 24 Núm. 11 (november 2018) , p. 2316-2323
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4.
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8 p, 316.8 KB |
Solid organ transplantation after hematopoietic stem cell transplantation in childhood : A multicentric retrospective survey
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Faraci, Maura (Istituto G Gaslini) ;
Bertaina, Alice (Stanford University) ;
Dalissier, Arnaud (European Society for Blood and Marrow Transplantation Pediatric Disease Working Party) ;
Ifversen, Marianne (Copenhagen University Hospital) ;
Schulz, Ansgar (University Medical Center) ;
Gennery, Andrew (Great North Children's Hospital) ;
Burkhardt, Birgit (University Hospital of Münster (Alemanya)) ;
Badell Serra, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Díaz de Heredia, Cristina (Vall d'Hebron Institut d'Oncologia) ;
Lanino, Edoardo (Istituto G Gaslini) ;
Lankester, Arjan C. (Leiden University Medical Center) ;
Gruhn, Bernd (Jena University Hospital (Alemania)) ;
Matthes-Martin, Susanne Medical University of Vienna ;
Kühl, Joern S. (Universitätsklinikum Leipzig) ;
Varotto, Stefania (University Hospital of Padova (Pàdua, Itàlia)) ;
Paillard, Catherine (Hôpital Hautepierre) ;
Guilmatre, Audrey (Hôpital Armand Trousseau (París, França)) ;
Sastre, Ana (Hospital Universitario La Paz (Madrid)) ;
Abecasis, Manuel (Instute Portugues Oncologia Lisboa) ;
Garwer, Birgit (University Hospital Eppendorf) ;
Sedlacek, Petr (University Hospital Motol) ;
Boelens, Jaap Jan (Memorial Sloan Kettering Cancer Center) ;
Beohou, Eric (European Society for Blood and Marrow Transplantation Pediatric Disease Working Party) ;
Bader, Peter (University Hospital of Frankfurt (Alemanya)) ;
Universitat Autònoma de Barcelona
We report data obtained from a retrospective multicenter pediatric survey on behalf of the European Society for Blood and Marrow Transplantation (EBMT). Information on solid organ transplantation (SOT) performed in pediatric recipients of either autologous or allogeneic hematopoietic stem cell transplantation (HSCT) between 1984 and 2016 was collected in 20 pediatric EBMT Centers (25. [...]
2019 - 10.1111/ajt.15240
American Journal of Transplantation, Vol. 19 Núm. 6 (june 2019) , p. 1798-1805
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19 p, 3.2 MB |
Hematopoietic cell transplantation in severe combined immunodeficiency : The SCETIDE 2006-2014 European cohort
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Lankester, Arjan C. (Pediatric Stem Cell Transplantation Program and Laboratory for Pediatric Immunology. Willem-Alexander Children's Hospital. Leiden University Medical Center) ;
Neven, Benedicte (Institut Imagine. INSERM UMR1163. Laboratory of Immunogenetics of Pediatric Autoimmune Diseases) ;
Mahlaoui, Nizar (French National Reference Center for Primary Immunodeficiencies (CEREDIH) and European Registry for Stem Cell Transplantation for Primary Immunodeficiencies (SCETIDE). Hôpital Universitaire Necker-Enfants malades. Assistance Publique-Hôpitaux de Paris (AP-HP)) ;
von Asmuth, Erik G.J. (Pediatric Stem Cell Transplantation Program and Laboratory for Pediatric Immunology. Willem-Alexander Children's Hospital. Leiden University Medical Center) ;
Courteille, Virginie (French National Reference Center for Primary Immunodeficiencies (CEREDIH) and European Registry for Stem Cell Transplantation for Primary Immunodeficiencies (SCETIDE). Hôpital Universitaire Necker-Enfants malades. Assistance Publique-Hôpitaux de Paris (AP-HP)) ;
Alligon, Mikael (French National Reference Center for Primary Immunodeficiencies (CEREDIH) and European Registry for Stem Cell Transplantation for Primary Immunodeficiencies (SCETIDE). Hôpital Universitaire Necker-Enfants malades. Assistance Publique-Hôpitaux de Paris (AP-HP)) ;
Albert, Michael H. (Dr von Haunersches University Children's Hospital) ;
Badell Serra, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Bader, Peter (Department for Children and Adolescents Medicine. Division for Stem Cell Transplantation and Immunology. University Hospital Frankfurt) ;
Balashov, Dmitry (Department for Hematopoietic Stem Cell Transplantation. Dmitriy Rogachev National Center for Pediatric Hematology. Oncology and Immunology) ;
Beier, Rita (Klinik für Pädiatrische Hämatologie und Onkologie. Hannover Medical School) ;
Bertrand, Yves (Institut d'Hématologie et d'Oncologie Pédiatrique. Hospices Civils de Lyon and Université Claude Bernard Lyon 1) ;
Blanche, Stephane (Unité d'Immuno-hematologie et Rhumatologie Pédiatrique. Hôpital Universitaire Necker-Enfants Malades. Assistance Publique-Hôpitaux de Paris (AP-HP)) ;
Bordon, Victoria (Department of Pediatric Hemato-oncology and Stem Cell Transplant. Ghent University Hospital) ;
Bredius, Robert G. (Pediatric Stem Cell Transplantation Program and Laboratory for Pediatric Immunology. Willem-Alexander Children's Hospital. Leiden University Medical Center) ;
Cant, Andrew (Translational and Clinical Research Institute. Newcastle University. and the Paediatric Haematopoietic Stem Cell Transplant Unit. Great North Children's Hospital) ;
Cavazzana, Marina (Laboratory of Genomic Dynamics in the Immune System. Institut Imagine. INSERM UMR1163) ;
Díaz de Heredia, Cristina (Vall d'Hebron Institut d'Oncologia) ;
Dogu, Figen (Department of PIA and the BMT Unit. Ankara University) ;
Ehlert, Karoline (Department of Pediatric Hematology and Oncology. University of Greifswald) ;
Entz-Werle, Natacha (Pediatric Onco-hematology Department-Pediatrics III. University Hospital of Strasbourg) ;
Fasth, Anders (Department of Pediatrics. Institute of Clinical Sciences. University of Gothenburg) ;
Ferrua, Francesca (Pediatric Immunohematology and Bone Marrow Transplantation Unit and the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget). IRCCS San Raffaele Scientific Institute) ;
Ferster, Alina (Department of Hemato-oncology. Hôpital Universitaire des Enfants Reine Fabiola) ;
Formankova, Renata (Department of Pediatric Hematology and Oncology. Teaching Hospital Motol. 2nd Medical School. Charles University Motol) ;
Friedrich, Wilhelm (Department of Pediatrics. University Medical Center Ulm) ;
Gonzalez-Vicent, Marta (Hospital del Niño Jesús. Hematopoietic Stem Cell Transplantation and Cellular Therapy Unit) ;
Gozdzik, Jolanta (Department of Clinical Immunology and Transplantation. Jagiellonian University Medical College) ;
Güngör, Tayfun (Department of Hematology. Oncology. Immunology. Gene Therapy and Stem Cell Transplantation. and Children's Research Center (CRC). University Children's Hospital) ;
Hoenig, Manfred (Department of Pediatrics. University Medical Center Ulm) ;
Ikinciogullari, Aydan (Department of PIA and the BMT Unit. Ankara University) ;
Kalwak, Krzysztof (Department of Pediatric Hematology. Oncology. and BMT. Wroclaw Medical University) ;
Kansoy, Savas (Department of Pediatric Hematology and Oncology. Ege University Hospital) ;
Kupesiz, Alphan (Department of Pediatrics. Hematology. and Oncology. Akdeniz University School of Medicine) ;
Lanfranchi, Arnalda (Diagnostic Department. Stem Cell Laboratory. Section of Hematology and Blood Coagulation. Clinical Chemistry Laboratory. ASST Spedali Civili) ;
Lindemans, Caroline A. (Department of Pediatrics. University Medical Center Utrecht. University of Utrecht) ;
Meisel, Roland (Department of Pediatric Oncology. Hematology. and Clinical Immunology. Medical Faculty. Division of Pediatric Stem Cell Therapy. Heinrich-Heine-University) ;
Michel, Gerard (Service d'Hématologie Immunologie Oncologie Pédiatrique. CHU La Timone) ;
Miranda, Nuno A. A. (BMT Unit. Instituto Português de Oncologia de Lisboa) ;
Moraleda, Jose (Hospital Virgen de la Arrixaca. Instituto Murciano de Investigación Biosanitaria) ;
Moshous, Despina (Laboratory of Genomic Dynamics in the Immune System. Institut Imagine. INSERM UMR1163) ;
Pichler, Herbert (Department of Stem Cell Transplantation. Children's Cancer Institute. St Anna Hospital) ;
Rao, Kanchan (Great Ormond Street (GOS) Hospital for Children NHS Foundation Trust and University College London GOS Institute of Child Health) ;
Sedlacek, Petr (Department of Pediatric Hematology and Oncology. Teaching Hospital Motol. 2nd Medical School. Charles University Motol) ;
Slatter, Mary (Translational and Clinical Research Institute. Newcastle University. and the Paediatric Haematopoietic Stem Cell Transplant Unit. Great North Children's Hospital) ;
Soncini, Elena (Pediatric Oncohaematology and BMT Unit. Children's Hospital Brescia) ;
Speckmann, Carsten (Department of Pediatric Hematology and Oncology. Center for Pediatrics and Adolescent Medicine. Institute for Immunodeficiency. Center for Chronic Immunodeficiency (CCI). Faculty of Medicine. Medical Center. University of Freiburg) ;
Sundin, Mikael (Section of Pediatric Hematology. Immunology. and HCT. Astrid Lindgren Children's Hospital. Karolinska University Hospital. and Division of Pediatrics. CLINTEC. Karolinska Institutet) ;
Toren, Amos (Paediatric Hemato-oncology and BMT. Sheba Medical Center) ;
Vettenranta, Kim (University of Helsinki and Children's Hospital. University of Helsinki) ;
Worth, Austen (Great Ormond Street (GOS) Hospital for Children NHS Foundation Trust and University College London GOS Institute of Child Health) ;
Yeşilipek, Mehmet A. (Pediatric Hematology. Oncology. and Pediatric Stem Cell Transplantation Unit. Medicalpark Antalya & Göztepe Hospitals) ;
Zecca, Marco (Pediatric Hematology/Oncology. Fondazione IRCCS Policlinico San Matteo) ;
Porta, Fulvio (Pediatric Oncohaematology and BMT Unit. Children's Hospital Brescia) ;
Schulz, Ansgar (Department of Pediatrics. University Medical Center Ulm) ;
Veys, Paul (Great Ormond Street (GOS) Hospital for Children NHS Foundation Trust and University College London GOS Institute of Child Health) ;
Fischer, Alain (Université de Paris) ;
Gennery, Andrew R. (Translational and Clinical Research Institute. Newcastle University. and the Paediatric Haematopoietic Stem Cell Transplant Unit. Great North Children's Hospital)
Background: Hematopoietic stem cell transplantation (HSCT) represents a curative treatment for patients with severe combined immunodeficiency (SCID), a group of monogenic immune disorders with an otherwise fatal outcome. [...]
2022 - 10.1016/j.jaci.2021.10.017
The Journal of Allergy and Clinical Immunology, Vol. 149 Núm. 5 (may 2022) , p. 1744-1754.e8
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10 p, 723.5 KB |
Experience of the Spanish Group for Hematopoietic Transplantation (GETMON-GETH) in allogenic hematopoietic stem cell transplantation in Philadelphia acute lymphoblastic leukemia Experiencia del Grupo Español de Trasplante Hematopoyético (GETMON-GETH) en el trasplante alogénico de progenitores hematopoyéticos en leucemia aguda linfoblástica Philadelphia
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Galán Gómez, Víctor (Hospital Universitario La Paz (Madrid)) ;
de la Fuente Regaño, Lydia (Universidad Autónoma de Madrid. Facultad de Medicina) ;
Rodríguez Villa, Antonia (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Díaz de Heredia, Cristina (Hospital Universitari Vall d'Hebron) ;
González Vicent, Marta (Hospital Infantil Universitario Niño Jesús (Madrid)) ;
Badell Serra, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Fernández, José María (Hospital Universitari i Politècnic La Fe (València)) ;
Pascual Martínez, Antonia Isabel (Hospital Materno Infantil Carlos Haya. Hemato-Oncología Pediátrica) ;
Pérez Hurtado, José María (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
López Duarte, Mónica (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Maldonado Regalado, M.Soledad (Hospital Universitario Ramón y Cajal (Madrid)) ;
Pérez-Martínez, Antonio (Hospital Universitario La Paz (Madrid))
Introduction: Outcomes in patients diagnosed of acute lymphoblastic leukemia with Philadelphia chromosome (Ph-ALL) remains unfavourable compared to other subtypes of acute lymphoblastic leukemia despite improvements in drug treatments as well as advances in hematopoietic stem cell transplantation (HSCT). [...]
2022 - 10.1016/j.anpedi.2021.02.015
Anales de pediatría, Vol. 96 Núm. 4 (abril 2022) , p. 309-318
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12 p, 659.9 KB |
Measurable Residual Disease Assessed by Flow-Cytometry Is a Stable Prognostic Factor for Pediatric T-Cell Acute Lymphoblastic Leukemia in Consecutive SEHOP Protocols Whereas the Impact of Oncogenetics Depends on Treatment
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Vega-García, N. (Institut de Recerca Sant Joan de Déu) ;
Perez-Jaume, S. (Institut de Recerca Hospital Sant Joan de Déu Barcelona) ;
Esperanza-Cebollada, Elena (Institut de Recerca Sant Joan de Déu) ;
Vicente-Garcés, C. (Institut de Recerca Sant Joan de Déu) ;
Torrebadell, M. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Jiménez-Velasco, Antonio (Hospital Regional Universitario Carlos Haya (Málaga)) ;
Ortega, M. (Hospital Universitari Vall d'Hebron) ;
Llop, M. (Centro de Investigación Biomédica en Red de Cáncer) ;
Abad, Lorea (Hospital Infantil Universitario Niño Jesús (Madrid)) ;
Vagace, J.M. (Hospital Materno Infantil) ;
Minguela, A. (Instituto Murciano de Investigación Biosanitaria) ;
Pratcorona, Marta (Institut d'Investigació Biomèdica Sant Pau) ;
Sánchez-Garcia, J. (Instituto Maimónides de Investigación Biomédica de Córdoba) ;
García-Calderón, C.B. (Instituto de Biomedicina de Sevilla) ;
Gómez-Casares, M.T. (Hospital Universitario de Gran Canaria Dr. Negrín) ;
Martín-Clavero, E. (Hospital Universitario) ;
Escudero, A. (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Riñón Martinez-Gallo, M. (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Muñoz, L. (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Velasco, M.R. (Haematology Department. Hospital Virgen de la Salud) ;
García-Morin, M. (Hospital General Universitario Gregorio Marañón) ;
Català, Albert (Institut de Recerca Sant Joan de Déu) ;
Pascual, A. (Hospital Regional Universitario Carlos Haya (Málaga)) ;
Velasco, P. (Hospital Universitari Vall d'Hebron) ;
Fernández, J.M. (Hospital Universitari i Politècnic La Fe (València)) ;
Lassaletta, Álvaro (Hospital Infantil Universitario Niño Jesús (Madrid)) ;
Fuster, José Luis (Instituto Murciano de Investigación Biosanitaria) ;
Badell Serra, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Molinos-Quintana, Á. (Instituto de Biomedicina de Sevilla) ;
Molinés, A. (H.U. Materno Infantil de Canarias) ;
Guerra-García, P. (Hospital Universitario La Paz (Madrid)) ;
Pérez-Martínez, Antonio (Hospital Universitario La Paz (Madrid)) ;
García-Abós, M. (Hospital de Donostia (Sant Sebastià, País Basc)) ;
Robles Ortiz, R. (Complejo Hospitalario de Navarra) ;
Pisa, S. (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Adán, R. (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Díaz de Heredia, Cristina (Hospital Universitari Vall d'Hebron) ;
Dapena, José Luis (Institut de Recerca Sant Joan de Déu) ;
Rives, S. (Institut de Recerca Sant Joan de Déu) ;
Ramírez-Orellana, M. (Hospital Infantil Universitario Niño Jesús (Madrid)) ;
Camós, Mireia (Centro de Investigación Biomédica en Red de Enfermedades Raras)
Robust and applicable risk-stratifying genetic factors at diagnosis in pediatric T-cell acute lymphoblastic leukemia (T-ALL) are still lacking, and most protocols rely on measurable residual disease (MRD) assessment. [...]
2021 - 10.3389/fped.2020.614521
Frontiers in Pediatrics, Vol. 8 (february 2021) , p. 614521
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9 p, 1.4 MB |
Usefulness of NGS for Diagnosis of Dominant Beta-Thalassemia and Unstable Hemoglobinopathies in Five Clinical Cases
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Rizzuto, Valeria (Universitat de Barcelona. Departament de Medicina) ;
Koopmann, Tamara T. (Leiden University Medical Center) ;
Blanco, Adoración (Hospital Universitari Vall d'Hebron) ;
Tazón-Vega, Bárbara (Hospital Universitari Vall d'Hebron) ;
Idrizovic, Amira (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Díaz de Heredia, Cristina (Hospital Universitari Vall d'Hebron) ;
Del Orbe Barreto, Rafael Andrés (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Pampliega, Miriam Vara (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Velasco, Pablo (Hospital Universitari Vall d'Hebron) ;
Beneitez Pastor, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Santen, Gijs Santen W.E. (Leiden University Medical Center) ;
Waisfisz, Quinten (VU Medical Center) ;
Elting, Mariet (VU Medical Center) ;
Smiers, Frans J.W. (Leiden University Medical Center) ;
de Pagter, Anne J. (Leiden University Medical Center) ;
Kerkhoffs, Jean Louis H. (AGA City Hospital) ;
Harteveld, Cornelis L. (Leiden University Medical Center) ;
Mañú Pereira, María del Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras
Unstable hemoglobinopathies (UHs) are rare anemia disorders (RADs) characterized by abnormal hemoglobin (Hb) variants with decreased stability. UHs are therefore easily precipitating, causing hemolysis and, in some cases, leading to dominant beta-thalassemia (dBTHAL). [...]
2021 - 10.3389/fphys.2021.628236
Frontiers in physiology, Vol. 12 (may 2021) , p. 628236
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16 p, 2.4 MB |
TYK2 Variants in B-Acute Lymphoblastic Leukaemia
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Turrubiartes-Martínez, Edgar (Instituto de Investigación Hospital Universitario de la Princesa) ;
Bodega-Mayor, Irene (Instituto de Investigación Hospital Universitario de la Princesa) ;
Delgado-Wicke, Pablo (Instituto de Investigación Hospital Universitario de la Princesa) ;
Molina-Jiménez, Francisca (Instituto de Investigación Hospital Universitario de la Princesa) ;
Casique-Aguirre, Diana (Latin University of Mexico) ;
González-Andrade, Martín (Universidad Nacional Autónoma de México) ;
Rapado, Inmaculada (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12)) ;
Camós, Mireia (University Hospital Sant Joan de Déu) ;
Díaz de Heredia, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Barragán, Eva (Hospital Universitari i Politècnic La Fe (València)) ;
Ramírez, Manuel (Hospital Infantil Universitario Niño Jesús (Madrid)) ;
Aguado, Beatriz (Instituto de Investigación Hospital Universitario de la Princesa) ;
Figuera, Ángela (Instituto de Investigación Hospital Universitario de la Princesa) ;
Martínez-López, Joaquín (Complutense University of Madrid) ;
Fernández-Ruiz, Elena (Universidad Autónoma de Madrid) ;
Universitat Autònoma de Barcelona
B-cell precursor acute lymphoblastic leukaemia (B-ALL) is a malignancy of lymphoid progenitor cells with altered genes including the Janus kinase (JAK) gene family. Among them, tyrosine kinase 2 (TYK2) is involved in signal transduction of cytokines such as interferon (IFN) α/β through IFN−α/β receptor alpha chain (IFNAR1). [...]
2020 - 10.3390/genes11121434
Genes, Vol. 11 (november 2020)
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10 p, 841.7 KB |
Improved collection of hematopoietic stem cells and progenitors from Fanconi anemia patients for gene therapy purposes
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Sevilla, Julián (Hospital Infantil Universitario Niño Jesús (Madrid)) ;
Navarro Ordóñez, Susanna (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Río, Paula (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Sánchez-Domínguez, Rebeca (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Zubicaray, Josune (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Gálvez, Eva (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Merino, Eva (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Sebastián, Elena (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Azqueta, Carmen (Banc de Sang i Teixits de Catalunya) ;
Casado, José A. (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Segovia, José C. (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Alberquilla, Omaira (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Bogliolo, Massimo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Román-Rodríguez, Francisco J. (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Giménez, Yari (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Larcher, Lise (Université de Paris. Institut de Recherche Saint-Louis) ;
Salgado Sánchez, Rocío Nieves (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Pujol, Roser M. (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Hladun, Raquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Castillo, Ana (Hospital Infantil Universitario Niño Jesús (Madrid)) ;
Soulier, Jean (Université de Paris. Institut de Recherche Saint-Louis) ;
Querol, Sergi (Banc de Sang i Teixits de Catalunya) ;
Fernández, Jesús (Banc de Sang i Teixits de Catalunya) ;
Schwartz, Jonathan (Rocket Pharmaceuticals Inc. (New York)) ;
García de Andoín, Nagore (Hospital Universitario de Donostia (Sant Sebastià, País Basc)) ;
López, Ricardo (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Català, Albert (Institut de Recerca Pediàtrica Sant Joan de Déu) ;
Surrallés i Calonge, Jordi (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Díaz de Heredia, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bueren, Juan (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz)
Difficulties in the collection of hematopoietic stem and progenitor cells (HSPCs) from Fanconi anemia (FA) patients have limited the gene therapy in this disease. We have investigated (, NCT02931071) the safety and efficacy of filgrastim and plerixafor for mobilization of HSPCs and collection by leukapheresis in FA patients. [...]
2021 - 10.1016/j.omtm.2021.06.001
Molecular Therapy. Methods & Clinical Development, Vol. 22 (September 2021) , p. 66-75
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