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17 p, 921.2 KB |
Real-World Validation of Molecular International Prognostic Scoring System for Myelodysplastic Syndromes
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Sauta, Elisabetta (Humanitas Clinical and Research Center (Itàlia)) ;
Robin, Marie (Department of Hematology and Bone Marrow Transplantation. Hôpital Saint-Louis (França)) ;
Bersanelli, Mateo (Department of Biomedical Sciences. Humanitas University) ;
Travaglino, Erica (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Meggendorfer, Manje (Mll Munich Leukemia Laboratory) ;
Zhao, Lin-Pierre (Department of Hematology and Bone Marrow Transplantation. Hôpital Saint-Louis (França)) ;
Caballero Berrocal, Juan Carlos (Hematology Department. Hospital Universitario de Salamanca) ;
Sala, Claudia (Experimental. Diagnostic and Specialty Medicine. Dimes) ;
Maggioni, Giulia (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Bernardi, Massimo (University Vita-Salute San Raffaele (Itàlia)) ;
Di Grazia, Carmen (Irccs Ospedale Policlinico San Martino) ;
Vago, Luca (University Vita-Salute San Raffaele (Itàlia)) ;
Rivoli, Giulia (Irccs Ospedale Policlinico San Martino) ;
Borin, Lorenza (Ospedale San Gerardo) ;
D'Amico, Saverio (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Tentori, Cristina Astrid (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Ubezio, Marta (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Campagna, Alessia (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Russo, Antonio (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Mannina, Daniele (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Lanino, Luca (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Chiusolo, Patrizia (Università Cattolica Del Sacro Cuore) ;
Giaccone, Luisa (Department of Molecular Biotechnology and Health Sciences. University of Turin) ;
Voso, Maria Teresa (Tor Vergata University) ;
Riva, Maria (Asst Grande Ospedale Metropolitano Niguarda) ;
Oliva, Esther Natalie (Grande Ospedale Metropolitano Bianchi Melacrino Morelli) ;
Zampini, Matteo (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Riva, Elena (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Nibourel, Olivier (Chu Lille) ;
Bicchieri, Marinela (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Bolli, Niccolo (Department of Oncology and Hemato-Oncology. University of Milan) ;
Rambaldi, Alessandro (Azienda Ospedaliera Papa Giovanni Xxiii) ;
Passamonti, Francesco (Department of Medicine and Surgery. University of Insubria) ;
Savevski, Victor (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Santoro, Armando (Department of Biomedical Sciences. Humanitas University) ;
Germing, Ulrich (Department of Hematology. Heinrich-Heine-University. University Clinic) ;
Kordasti, Shahram (Hematology Department. DISCLIMO-Università Politecnica Delle Marche) ;
Santini, Valeria (University of Florence) ;
Diez-Campelo, María (Hospital Universitario de Salamanca) ;
Sanz, Guillermo (Hospital Universitari i Politècnic La Fe (València)) ;
Sole, F (Institut de Recerca Contra la Leucèmia Josep Carreras) ;
Kern, Wolfgang (Mll Munich Leukemia Laboratory) ;
Platzbecker, Uwe (University Hospital Leipzig) ;
Arenillas, Leonor (Department of Hematology and Bone Marrow Transplantation. Hôpital Saint-Louis) ;
Fenaux, Pierre (Department of Hematology and Bone Marrow Transplantation. Hôpital Saint-Louis) ;
Haferlach, Torsten (Mll Munich Leukemia Laboratory) ;
Castellani, Gastone (Experimental. Diagnostic and Specialty Medicine. Dimes) ;
Della Porta, Matteo Giovanni (Department of Biomedical Sciences. Humanitas University)
PURPOSEMyelodysplastic syndromes (MDS) are heterogeneous myeloid neoplasms in which a risk-adapted treatment strategy is needed. Recently, a new clinical-molecular prognostic model, the Molecular International Prognostic Scoring System (IPSS-M) was proposed to improve the prediction of clinical outcome of the currently available tool (Revised International Prognostic Scoring System [IPSS-R]). [...]
2023 -  10.1200/JCO.22.01784
Journal of Clinical Oncology, Vol. 41 Núm. 15 (20 2023) , p. 2827-2842
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7 p, 363.5 KB |
The EHA Research Roadmap : Malignant Myeloid Diseases
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Döhner, Hartmut (Department of Internal Medicine III. Ulm University Hospital) ;
Malcovati, Luca (Istituto di Ricovero e Cura A Carattere Scientifico (IRCCS)) ;
Ossenkoppele, Gert J. (Amsterdam UMC. Department of Hematology. VU University. Medical Center) ;
Hochhaus, Andreas (Universitätsklinikum Jena. Klinik für Innere Medizin II. Hämatologie/Onkologie) ;
Maria Vannucchi, Alessandro (Center Research and Innovation of Myeloproliferative Neoplasms. CRIMM. University of Florence) ;
Bullinger, Lars (Freie Universität Berlin) ;
Cervantes, Francisco (Hospital Clínic i Provincial de Barcelona) ;
Craddock, Charles (Centre for Clinical Haematology. Queen Elizabeth Hospital) ;
de Witte, Theo. (Radboud University. Medical Centre. Nijmegen) ;
Döhner, Konstanze (Department of Internal Medicine III. Ulm University Hospital) ;
Dombret, Hervé (Institut de Recherche Saint-Louis (IRSL). Université de Paris. Hôpital Saint-Louis) ;
Fenaux, Pierre (Département (DMU) d'Hématologie et Immunologie. Assistance Publique Hôpitaux de Paris. Hôpital St Louis. Université de Paris) ;
Geissler, Jan (Leukemia Patient Advocates Foundation) ;
Germing, Ulrich (Klinik für Hämatologie. Onkologie und Klinische Immunologie. Universitätsklinikum Düsseldorf. Heinrich-Heine Universität Düsseldorf) ;
Guilhot, Francois (University of Poitiers) ;
Harrison, Claire (Department of Haematology. Guys and St thomas'Hospital) ;
Hellström-Lindberg, Eva (Karolinska Institutet (Estocolm, Suècia)) ;
Passamonti, Francesco (Department of Clinical and Biological Sciences. University of Turin. San Luigi University Hospital) ;
Sierra, Jorge (Institut d'Investigació Biomèdica Sant Pau) ;
Skoda, Radek (University Hospital Basel (Basilea, Suïssa)) ;
Wierzbowska, Agnieszka. (Multi-specialized Center of Oncology and Traumatology)
In 2016, the European Hematology Association (EHA) published the EHA Roadmap for European Hematology Research1 aiming to highlight achievements in the diagnostics and treatment of blood disorders, and to better inform European policy makers and other stakeholders about the urgent clinical and scientific needs and priorities in the field of hematology. [...]
2021 - 10.1097/HS9.0000000000000635
HemaSphere, Vol. 5 Núm. 9 (2021)
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15 p, 1.6 MB |
The ABNL-MARRO 001 study : a phase 1-2 study of randomly allocated active myeloid target compound combinations in MDS/MPN overlap syndromes
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Moyo, Tamara K. (Vanderbilt University School of Medicine) ;
Mendler, Jason H (University of Rochester Medical Center) ;
Itzykson, Raphael (Paris Diderot University) ;
Kishtagari, Ashwin (Vanderbilt University School of Medicine) ;
Solary, Eric (Institut Gustave Roussy. Université Paris-Saclay) ;
Seegmiller, Adam C. (Vanderbilt University School of Medicine) ;
Gerds, Aaron T. (Cleveland Clinic) ;
Ayers, Gregory D. (Vanderbilt University School of Medicine) ;
Dezern, Amy E. (Johns Hopkins University) ;
Nazha, Aziz (Cleveland Clinic) ;
Valent, Peter (Ludwig Boltzmann Institute for Hematology and Oncology. Medical University of Vienna) ;
Onida, Francesco (University of Milan) ;
Van Azizan de Loosdrecht, Arjan A. (Amsterdam UMC. University Medical Center) ;
Pleyer, Lisa (Salzburg Cancer Research Institute Center for Clinical Cancer and Immunology Trials) ;
Xicoy Cirici, Blanca (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Tibes, Raoul (Mayo Clinic) ;
Geissler, Klaus (Sigmund Freud University) ;
Komrokji, Rami S. (H. Lee Moffitt Cancer Center) ;
Zhang, Jing (University of Wisconsin-Madison) ;
Germing, Ulrich (Department of Hematology. Oncology. and Clinical Immunology. University of Duesseldorf) ;
Steensma, David P. (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Wiseman, Daniel H. (University of Manchester) ;
Pfeilstöecker, Michael (Hanusch Hospital and Ludwig Boltzmann Institute for Hematology and Oncology) ;
Elena, Chiara (University of Pavia) ;
Cross, Nicholas C P (University of Southampton) ;
Luebbert, Michael (University of Freiburg) ;
Mesa, Ruben A. (Mays Cancer Center at UT Health San Antonio MD Anderson) ;
Montalban-Bravo, Guillermo (MD Anderson Cancer Center) ;
Sanz, G.F. (Hospital Universitari i Politècnic La Fe (València)) ;
Platzbecker, Uwe (University Hospital Leipzig) ;
Patnaik, Mrinal M. (Mayo Clinic) ;
Padron, Eric (H. Lee Moffitt Cancer Center) ;
Santini, Valeria (University of Florence) ;
Fenaux, Pierre (Paris Diderot University) ;
Savona, Michael R. (Vanderbilt University School of Medicine) ;
Universitat Autònoma de Barcelona
Background: Myelodysplastic/myeloproliferative neoplasms (MDS/MPN) comprise several rare hematologic malignancies with shared concomitant dysplastic and proliferative clinicopathologic features of bone marrow failure and propensity of acute leukemic transformation, and have significant impact on patient quality of life. [...]
2022 - 10.1186/s12885-022-10073-w
BMC Cancer, Vol. 22 Núm. 1 (december 2022) , p. 1013
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12 p, 1.1 MB |
The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants
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Rio-Machin, Ana (Queen Mary University of London) ;
Vulliamy, Tom (Queen Mary University of London) ;
Hug, Nele (University of Edinburgh) ;
Walne, Amanda (Queen Mary University of London) ;
Tawana, Kiran (Addenbrookes Hospital (Cambridge, Regne Unit)) ;
Cardoso, Shirleny (Queen Mary University of London) ;
Ellison, Alicia (Queen Mary University of London) ;
Pontikos, Nikolas (Queen Mary University of London) ;
Wang, Jun (Queen Mary University of London) ;
Tummala, Hemanth (Queen Mary University of London) ;
Al Seraihi, Ahad Fahad H. (Queen Mary University of London) ;
Alnajar, Jenna (Queen Mary University of London) ;
Bewicke-Copley, Findlay (Queen Mary University of London) ;
Armes, Hannah (Queen Mary University of London) ;
Barnett, Michael (University of British Columbia) ;
Bloor, Adrian (Christie Hospital) ;
Bödör, Csaba (Semmelweis University) ;
Bowen, David (St James's University Hospital) ;
Fenaux, Pierre (Université Paris) ;
Green, Andrew (Our Lady's Children's Hospital) ;
Hallahan, Andrew (Queensland Children's Hospital (Austràlia)) ;
Hjorth-Hansen, Henrik (St Norwegian University of Science and Technology) ;
Hossain, Upal (Barts NHS Trust) ;
Killick, Sally (Royal Bournemouth General Hospital (Dorset, Regne Unit)) ;
Lawson, Sarah (Birmingham Children's Hospital) ;
Layton, Mark (Hammersmith Hospital (Londres)) ;
Male, Alison M. (Great Ormond Street Hospital for Children (Londres)) ;
Marsh, Judith (King's College Hospital NHS Foundation Trust) ;
Mehta, Priyanka (University Hospitals Bristol NHS Foundation Trust) ;
Mous, Rogier (Universitair Medisch Centrum Utrecht) ;
Nomdedeu, Josep (Institut d'Investigació Biomèdica Sant Pau) ;
Owen, Carolyn (Foothills Medical Centre) ;
Pavlu, Jiri (Hammersmith Hospital (Londres)) ;
Payne, Elspeth M. (University College London) ;
Protheroe, Rachel E. (University Hospitals Bristol NHS Foundation Trust) ;
Preudhomme, Claude (Universitaire de Lille. Jean-Pierre Aubert Research Center) ;
Pujol-Moix, Nuria (Institut d'Investigació Biomèdica Sant Pau) ;
Renneville, Aline (Broad Institute of MIT and Harvard) ;
Russell, Nigel (Nottingham University Hospitals NHS Trust (Regne Unit)) ;
Saggar, Anand (St George's Hospital Medical School) ;
Sciuccati, Gabriela (Hospital de Pediatría "Prof. Dr. Juan P. Garrahan") ;
Taussig, David (Royal Marsden Hospital (Regne Unit)) ;
Toze, Cynthia L. (University of British Columbia) ;
Uyttebroeck, Anne (University Hospitals Leuven (Bèlgica)) ;
Vandenberghe, Peter (University Hospitals Leuven (Bèlgica)) ;
Schlegelberger, Brigitte (Medizinische Hochschule Hannover) ;
Ripperger, Tim (Medizinische Hochschule Hannover) ;
Steinemann, Doris (Medizinische Hochschule Hannover) ;
Wu, John (British Columbia Children's Hospital (Vancouver, Canadà)) ;
Mason, Joanne (Birmingham Women's NHS Foundation Trust) ;
Page, Paula (Birmingham Women's NHS Foundation Trust) ;
Akiki, Susanna (Qatar Rehabilitation Institute) ;
Reay, Kim (Birmingham Women's NHS Foundation Trust) ;
Cavenagh, Jamie D. (Barts NHS Trust) ;
Plagnol, Vincent (University College London) ;
Caceres, Javier F. (University of Edinburgh) ;
Fitzgibbon, Jude (Queen Mary University of London) ;
Dokal, Inderjeet (Barts Health NHS Trust) ;
Universitat Autònoma de Barcelona
The inclusion of familial myeloid malignancies as a separate disease entity in the revised WHO classification has renewed efforts to improve the recognition and management of this group of at risk individuals. [...]
2020 - 10.1038/s41467-020-14829-5
Nature communications, Vol. 11 (february 2020)
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1 p, 257.6 KB |
Publisher Correction : Outcome of older (≥70 years) APL patients frontline treated with or without arsenic trioxide-an International Collaborative Study
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Kayser, Sabine (Heidelberg University Hospital (Alemanya)) ;
Rahmé, Ramy (Université Paris Diderot. Hôpital Saint Louis) ;
Martínez-Cuadrón, David (Centro de Investigación Biomédica en Red de Cáncer) ;
Ghiaur, Gabriel (Johns Hopkins University) ;
Thomas, Xavier (Centre Hospitalier Lyon-Sud) ;
Guerci-Bresler, Agnes (Nancy University Hospital) ;
Garrido, Ana (Institut d'Investigació Biomèdica Sant Pau) ;
Pigneux, Arnaud (Bordeaux University Hospital (França)) ;
Gil, Cristina (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Raffoux, Emmanuel (Université Paris Diderot) ;
Tormo, Mar (Universitat de València) ;
Vey, Norbert (Institut Paoli Calmette) ;
de la Serna, Javier (Hospital Universitario 12 de Octubre (Madrid)) ;
Salamero, Olga (Hospital Universitari Vall d'Hebron) ;
Lengfelder, Eva (University Hospital Mannheim (Alemanya)) ;
Levis, Mark (Johns Hopkins University) ;
Fenaux, Pierre (Université Paris Diderot) ;
Sanz, Miguel A.. (Centro de Investigación Biomédica en Red de Cáncer) ;
Platzbecker, Uwe (University Hospital Leipzig. Medical Clinic and Policlinic I, Hematology and Cellular Therapy) ;
Schlenk, Richard F. (NCT Trial Center, National Center for Tumor Diseases, German Cancer Research Center and Heidelberg University Hospital) ;
Adès, Lionel (Université Paris Diderot) ;
Montesinos, Pau (Centro de Investigación Biomédica en Red de Cáncer) ;
Universitat Autònoma de Barcelona
2021 - 10.1038/s41375-021-01358-3
Leukemia, Vol. 35 (november 2021) , p. 3631
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9 p, 621.5 KB |
Outcome of older (≥70 years) APL patients frontline treated with or without arsenic trioxide-an International Collaborative Study
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Kayser, Sabine (Heidelberg University Hospital (Alemanya)) ;
Rahmé, Ramy (Université Paris Diderot) ;
Martínez-Cuadrón, David (Centro de Investigación Biomédica en Red de Cáncer) ;
Ghiaur, Gabriel (Johns Hopkins University) ;
Thomas, Xavier (Centre Hospitalier Lyon-Sud. Hospices Civils de Lyon) ;
Sobas, Marta (Wroclaw Medical University) ;
Guerci-Bresler, Agnes (Nancy University Hospital) ;
Garrido, Ana (Institut d'Investigació Biomèdica Sant Pau) ;
Pigneux, Arnaud (Bordeaux University Hospital (França)) ;
Gil, Cristina (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Raffoux, Emmanuel (Université Paris Diderot. Hôpital Saint Louis) ;
Tormo, Mar (Hospital Clínic Universitari (València)) ;
Vey, Norbert (Institut Paoli Calmette) ;
de la Serna, Javier (Hospital Universitario 12 de Octubre (Madrid)) ;
Salamero, Olga (Hospital Universitari Vall d'Hebron) ;
Lengfelder, Eva (University Hospital Mannheim (Alemanya)) ;
Levis, Mark (Johns Hopkins University) ;
Fenaux, Pierre (Université Paris Diderot. Hôpital Saint Louis) ;
Sanz, Miguel A.. (Centro de Investigación Biomédica en Red de Cáncer) ;
Platzbecker, Uwe (University Hospital Leipzig) ;
Schlenk, Richard F. (German Cancer Research Center and Heidelberg University Hospital) ;
Adès, Lionel (Université Paris Diderot) ;
Montesinos, Pau (Centro de Investigación Biomédica en Red de Cáncer) ;
Universitat Autònoma de Barcelona
Data on outcome in older (≥70 years) patients with acute promyelocytic leukemia after treatment with arsenic trioxide (ATO) compared with standard chemotherapy (CTX) is scarce. We evaluated 433 patients (median age, 73. [...]
2020 - 10.1038/s41375-020-0758-4
Leukemia, Vol. 34 (february 2020) , p. 2333-2341
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