Resultats globals: 4 registres trobats en 0.01 segons.
Articles, 4 registres trobats
Articles 4 registres trobats  
1.
12 p, 3.7 MB Minimum Effective Dose of DPP-4 Inhibitors for Treating Early Stages of Diabetic Retinopathy in an Experimental Model / Bogdanov, Patricia (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ; Ramos, Hugo (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ; Valeri, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Deàs-Just, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Huerta, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Simó Canonge, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina) ; Hernández, Cristina (Universitat Autònoma de Barcelona. Departament de Medicina)
The neurovascular unit (NVU) plays an essential role in the development of diabetic retinopathy (DR). We previously reported that the topical administration (eye drops) of sitagliptin and saxagliptin, two dipeptidyl peptidase-4 inhibitors (DPP-4i), prevents retinal neurodegeneration and vascular leakage in db/db mice. [...]
2022 - 10.3390/biomedicines10020465
Biomedicines, Vol. 10 (february 2022)  
2.
10 p, 2.4 MB Effects of the topical administration of semaglutide on retinal neuroinflammation and vascular leakage in experimental diabetes / Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bogdanov, Patricia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ramos, Hugo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Huerta, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Simó-Servat, Olga (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Hernández, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Background: An unexpected increase in the rate of severe diabetic retinopathy was observed in the Semaglutide in Subjects with Type 2 Diabetes (SUSTAIN)-6 clinical trial. Although this effect was attributed to a rapid decrease in blood glucose levels, a direct deleterious effect of semaglutide on the retina could not be ruled out. [...]
2021 - 10.3390/biomedicines9080926
Biomedicines, Vol. 9 Núm. 8 (august 2021) , p. 926  
3.
12 p, 4.0 MB Beneficial Effects of Glucagon-Like Peptide-1 (GLP-1) in Diabetes-Induced Retinal Abnormalities : Involvement of Oxidative Stress / Ramos, Hugo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bogdanov, Patricia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sampedro, Joel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Huerta, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Simó Canonge, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina) ; Hernández, Cristina (Universitat Autònoma de Barcelona. Departament de Medicina)
Background: Hyperglycemia-induced oxidative stress plays a key role in diabetic complications, including diabetic retinopathy. The main goal of this study was to assess whether the topical administration (eye drops) of glucagon-like peptide-1 (GLP-1) has any effect on oxidative stress in the retina. [...]
2020 - 10.3390/antiox9090846
Antioxidants, Vol. 9 (september 2020)  
4.
14 p, 3.9 MB Low survival rate and muscle fiber-dependent aging effects in the McArdle disease mouse model / Real-Martinez, A. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Brull, Astrid (Sorbonne Université) ; Huerta, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Tarrasó, G. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Lucia, Alejandro (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Martin, M. A. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Arenas, Joaquín (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Andreu, A. L. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Nogales, Gisela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Vissing, John (University of Copenhagen) ; Krag, Thomas (University of Copenhagen) ; de Luna Salva, Noemí (Institut d'Investigació Biomèdica Sant Pau) ; Pinós Figueras, Tomàs (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
McArdle disease is an autosomal recessive disorder caused by the absence of the muscle glycogen phosphorylase, which leads to impairment of glycogen breakdown. The McArdle mouse, a model heavily affected by glycogen accumulation and exercise intolerance, was used to characterize disease progression at three different ages. [...]
2019 - 10.1038/s41598-019-41414-8
Scientific reports, Vol. 9 Núm. 1 (january 2019) , p. 5116  

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