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14 p, 2.1 MB A Protein Misfolding Shaking Amplification-based method for the spontaneous generation of hundreds of bona fide prions / Eraña, Hasier (ATLAS Molecular Pharma S. L) ; Sampedro-Torres-Quevedo, Cristina (Basque Research and Technology Alliance) ; Charco, Jorge M. (ATLAS Molecular Pharma S. L) ; Díaz-Domínguez, Carlos M. (Instituto de Salut Carlos III. Centro de Investigación Biomédica en Red de Enfermedades infecciosas) ; Peccati, Francesca (Basque Research and Technology Alliance) ; San-Juan-Ansoleaga, Maitena (Basque Research and Technology Alliance) ; Vidal Barba, Enric (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ; Gonçalves-Anjo, Nuno (Basque Research and Technology Alliance) ; Pérez-Castro, Miguel A. (Basque Research and Technology Alliance) ; González-Miranda, Ezequiel (Basque Research and Technology Alliance) ; Piñeiro, Patricia (Basque Research and Technology Alliance) ; Fernández-Veiga, Leire (Basque Research and Technology Alliance) ; Galarza-Ahumada, Josu (Basque Research and Technology Alliance) ; Fernández-Muñoz, Eva (Basque Research and Technology Alliance) ; Pérez de Nanclares, Guiomar (Hospital Universitario de Araba Molecular (Epi)Genetics Laboratory) ; Telling, Glenn (Colorado State University. Prion Research Center) ; Geijo, Maria V (NEIKER-Basque Institute for Agricultural Research and Development) ; Jiménez-Osés, Gonzalo (Basque Foundation for Science) ; Castilla, Joaquín (Basque Foundation for Science)
Prion diseases are a group of rapidly progressing neurodegenerative disorders caused by the misfolding of the endogenous prion protein (PrP C) into a pathogenic form (PrP Sc). This process, despite being the central event underlying these disorders, remains largely unknown at a molecular level, precluding the prediction of new potential outbreaks or interspecies transmission incidents. [...]
2024 - 10.1038/s41467-024-46360-2
Nature communications, Vol. 15 (march 2024)  

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