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27 p, 8.1 MB Integrative multi-omic cancer profiling reveals DNA methylation patterns associated with therapeutic vulnerability and cell-of-origin / Liang, Wen-Wei (Washington University in St. Louis) ; Lu, Rita Jui-Hsien Lu (Washington University in St. Louis) ; Jayasinghe, Reyka G. (Washington University in St. Louis) ; Foltz, Steven M. (Washington University in St. Louis) ; Porta-Pardo, Eduard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Geffen, Yifat (Massachusetts General Hospital) ; Wendl, Michael C. (Department of Mathematics. Washington University in St. Louis) ; Lazcano, Rossana (Departments of Pathology & Genomic Medicine. The University of Texas MD Anderson Cancer Center) ; Kolodziejczak, Iga (Medical University of Warsaw) ; Song, Yizhe (Washington University in St. Louis) ; Govindan, Akshay (Washington University in St. Louis) ; Demicco, Elisabeth G. (University of Toronto) ; Li, Xiang (Washington University in St. Louis) ; Li, Yize (Washington University in St. Louis) ; Sethuraman, Sunantha (Washington University in St. Louis) ; Payne, Samuel H. (Department of Biology. Brigham Young University) ; Fenyö, David (Department of Biochemistry and Molecular Pharmacology. NYU Grossman School of Medicine) ; Rodriguez, Henry (Office of Cancer Clinical Proteomics Research. National Cancer Institute) ; Wiznerowicz, Maciej (Poznań University of Medical Sciences) ; Shen, Hui (Van Andel Research Institute) ; Mani, D.R. (Broad Institute of Massachusetts Institute of Technology and Harvard) ; Rodland, Karin D. (Developmental. and Cancer Biology. Oregon Health & Science University) ; Lazar, Alexander J. (Departments of Pathology & Genomic Medicine. The University of Texas MD Anderson Cancer Center) ; Robles, Ana I. (Office of Cancer Clinical Proteomics Research) ; Ding, Li (Washington University in St. Louis) ; Universitat Autònoma de Barcelona
DNA methylation plays a critical role in establishing and maintaining cellular identity. However, it is frequently dysregulated during tumor development and is closely intertwined with other genetic alterations. [...]
2023 - 10.1016/j.ccell.2023.07.013
Cancer Cell, Vol. 41 Núm. 9 (november 2023) , p. 1567-1585.e7  
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