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Resultats globals: 2 registres trobats en 0.02 segons.
Articles, 2 registres trobats
Articles 2 registres trobats  
1.
9 p, 2.4 MB Pre-plaque conformational changes in Alzheimer's disease-linked Aβ and APP / Klementieva, O. (Lund University. Department of Experimental Medical Science) ; Willén, K. (Lund University. Department of Experimental Medical Science) ; Martinsson, Isak (Lund University. Department of Experimental Medical Science) ; Israelsson, B. (Lund University. Department of Experimental Medical Science) ; Engdahl, A. (Lund University. MAX IV Laboratory) ; Cladera i Cerdà, Josep (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Uvdal, P. (Lund University. Department of Chemistry) ; Gouras, G. K. (Lund University. Department of Experimental Medical Science)
Reducing levels of the aggregation-prone Aβ peptide that accumulates in the brain with Alzheimer's disease (AD) has been a major target of experimental therapies. An alternative approach may be to stabilize the physiological conformation of Aβ. [...]
2017 - 10.1038/ncomms14726
Nature communications, Vol. 8 (March 2017) , art. 14726  
Registre complet - Creative Commons
2.
12 p, 3.3 MB Poly(propylene imine) dendrimers with histidine-maltose shell as novel type of nanoparticles for synapse and memory protection / Aso, Ester (ALBA Laboratori de Llum de Sincrotró) ; Martinsson, Isak (Wallenberg Neuroscience Center) ; Appelhans, Dietmar (Leibniz Institute of Polymer Research Dresden) ; Effenberg, Christiane (Leibniz Institute of Polymer Research Dresden) ; Benseny Cases, Núria (ALBA Laboratori de Llum de Sincrotró) ; Cladera i Cerdà, Josep (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Gouras, Gunnar (Wallenberg Neuroscience Center) ; Ferrer, Isidro (Hospital Universitari de Bellvitge) ; Klementieva, Oxana (Wallenberg Neuroscience Center)
Poly(propylene imine) dendrimers have been shown to be promising 3-dimensional polymers for the use in the pharmaceutical and biomedical applications. Our aims of this study were first, to synthesize a novel type of dendrimer with poly(propylene imine) core and maltose-histidine shell (G4HisMal) assessing if maltose-histidine shell can improve the biocompatibility and the ability to cross the blood-brain barrier, and second, to investigate the potential of G4HisMal to protect Alzheimer disease transgenic mice from memory impairment. [...]
2019 - 10.1016/j.nano.2019.01.010
Nanomedicine, Vol. 17 (April 2019) , p. 198-209  
Registre complet - Creative Commons

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