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19 p, 6.0 MB Mitovesicles are a novel population of extracellular vesicles of mitochondrial origin altered in down syndrome / D'Acunzo, Pasquale (New York University. School of Medicine. Department of Psychiatry) ; Pérez-González, Rocío (Institut d'Investigació Biomèdica Sant Pau) ; Kim, Yohan (New York University. School of Medicine. Department of Psychiatry) ; Hargash, Tal (Center for Dementia Research. Nathan S. Kline Institute for Psychiatric Research) ; Miller, Chelsea (Center for Dementia Research. Nathan S. Kline Institute for Psychiatric Research) ; Alldred, Melissa J. (Department of Psychiatry. New York University. School of Medicine) ; Erdjument-Bromage, Hediye (New York University. School of Medicine. Kimmel Center for Biology and Medicine. The Skirball Institute) ; Penikalapati, Sai Charan (Center for Dementia Research. Nathan S. Kline Institute for Psychiatric Research) ; Pawlik, Monika (Center for Dementia Research. Nathan S. Kline Institute for Psychiatric Research) ; Saito, Mitsuo (Division of Neurochemistry. Nathan S. Kline Institute for Psychiatric Research) ; Saito, Mariko (New York University School of Medicine. Department of Psychiatry) ; Ginsberg, Stephen D. (New York University. School of Medicine. Department of Neuroscience and Physiology) ; Neubert, Thomas A. (Kimmel Center for Biology and Medicine. The Skirball Institute. New York University. School of Medicine) ; Goulbourne, Chris N. (Center for Dementia Research. Nathan S. Kline Institute for Psychiatric Research) ; Levy, Efrat (Department of Biochemistry and Molecular Pharmacology. New York University. School of Medicine)
Mitochondrial dysfunction is an established hallmark of aging and neurodegenerative disorders such as Down syndrome (DS) and Alzheimer's disease (AD). Using a high-resolution density gradient separation of extracellular vesicles (EVs) isolated from murine and human DS and diploid control brains, we identify and characterize a previously unknown population of double-membraned EVs containing multiple mitochondrial proteins distinct from previously described EV subtypes, including microvesicles and exosomes. [...]
2021 - 10.1126/sciadv.abe5085
Science advances, Vol. 7 Núm. 7 (december 2021) , p. eabe5085  
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