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12 p, 339.3 KB Efficacy and Safety of Rovalpituzumab Tesirine Compared With Topotecan as Second-Line Therapy in DLL3-High SCLC : Results From the Phase 3 TAHOE Study / Blackhall, Fiona (Department of Medical Oncology. The Christie National Health Service (NHS) Foundation Trust) ; Jao, K. (Department of Hematology and Oncology. Hopital du Sacre Coeur Montreal) ; Greillier, L. (Multidisciplinary Oncology and Therapeutic Innovations Department. Centre de Recherche en Cancérologie de Marseille (CRCM). Centre National de la Recherche Scientifique (CNRS). Institut National de la Santé et de la Recherche Médicale (INSERM). Assistance Publique-Hopitaux de Marseille (APHM). Aix-Marseille University) ; Cho, B.C. (Division of Medical Oncology. Department of Internal Medicine. Yonsei Cancer Center. Yonsei University College of Medicine) ; Penkov, K. (Private Medical Institution Euromedservice) ; Reguart, Noemi (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ; Nackaerts, K. (Department of Pulmonology and Respiratory Oncology. University Hospital Leuven. Katholieke Universiteit (KU) Leuven) ; Syrigos, K. (Department of Medicine. National and Kapodistrian University of Athens) ; Hansen, K. (Odense University Hospital (Dinamarca)) ; Schuette, W. (2nd Medical Department. Krankenhaus Martha-Maria Halle-Doelau. Halle) ; Cetnar, J. (Department of Medicine. Oregon Health & Science University) ; Cappuzzo, F. (Department of Medical Oncology. Istituto Nazionale Tumori Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS)) ; Okamoto, I. (Department of Medical Oncology. Kyushu University Hospital) ; Erman, M. (Department of Medical Oncology. Cancer Institute. Hacettepe University) ; Langer, S.W. (Rigshospitalet. University of Copenhagen) ; Kato, T. (Department of Thoracic Oncology. Kanagawa Cancer Center) ; Groen, H. (Department of Pulmonary Disease. University Medical Center Groningen. University of Groningen) ; Sun, Z. (AbbVie. Inc.) ; Luo, Y. (AbbVie. Inc.) ; Tanwani, P. (AbbVie. Inc.) ; Caffrey, L. (AbbVie. Inc.) ; Komarnitsky, P. (AbbVie. Inc.) ; Reinmuth, N. (Thoracic Oncology Department. Asklepios Fachkliniken München-Gauting)
Introduction: DLL3, an atypical Notch ligand, is expressed in SCLC tumors but is not detectable in normal adult tissues. Rovalpituzumab tesirine (Rova-T) is an antibody-drug conjugate containing a DLL3-targeting antibody tethered to a cytotoxic agent pyrrolobenzodiazepine by means of a protease-cleavable linker. [...]
2021 - 10.1016/j.jtho.2021.02.009
Journal of Thoracic Oncology, Vol. 16 Núm. 9 (september 2021) , p. 1547-1558  
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