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12 p, 940.4 KB An algorithm based on immunotherapy discontinuation and liver biopsy spares corticosteroids in two thirds of cases of severe checkpoint inhibitor-induced liver injury / Riveiro Barciela, Mar (Universitat Autònoma de Barcelona. Departament de Medicina) ; Barreira-Diaz, Ana (Hospital Universitari Vall d'Hebron) ; Salcedo, Maria-Teresa (Hospital Universitari Vall d'Hebron) ; Callejo, Ana (Hospital Universitari Vall d'Hebron) ; Muñoz Couselo, Eva (Hospital Universitari Vall d'Hebron) ; Iranzo, Patricia (Hospital Universitari Vall d'Hebron) ; Ortiz Velez, Carolina (Hospital Universitari Vall d'Hebron) ; Cedrés, Susana (Hospital Universitari Vall d'Hebron) ; Díaz Mejía, Nely (Hospital Universitari Vall d'Hebron) ; Ruiz Cobo, Juan Carlos (Hospital Universitari Vall d'Hebron) ; Morales, Rafael (Hospital Universitari Vall d'Hebron) ; Aguilar-Company, Juan (Hospital Universitari Vall d'Hebron) ; Zamora, Ester (Hospital Universitari Vall d'Hebron) ; Oliveira, Mafalda (Hospital Universitari Vall d'Hebron) ; Sanz-Martínez, María Teresa (Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Viladomiu, Lluis (Universitat Autònoma de Barcelona. Departament de Medicina) ; Martínez Gallo, Mónica (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Felip, Enriqueta (Hospital Universitari Vall d'Hebron) ; Buti, Maria (Universitat Autònoma de Barcelona. Departament de Medicina)
Background: There are few data on corticosteroids (CS)-sparing strategies for checkpoint inhibitor (ICI)-induced liver injury (ChILI). Aim: We aimed to assess the performance of a 2-step algorithm for severe ChILI, based on ICI temporary discontinuation (step-1) and, if lack of biochemical improvement, CS based on the degree of necroinflammation at biopsy (step-2). [...]
2024 - 10.1111/apt.17898
Alimentary Pharmacology and Therapeutics, Vol. 59 Núm. 7 (april 2024) , p. 865-876  
Detailed record - Creative Commons

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