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20 p, 4.0 MB |
Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target
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Roychowdhury, Tanmoy (Yale School of Medicine) ;
Klarin, Derek (VA Palo Alto Healthcare System) ;
Levin, Michael G. (University of Pennsylvania) ;
Spin, Joshua M. (Stanford University School of Medicine) ;
Rhee, Yae Hyun (Stanford University School of Medicine) ;
Deng, Alicia (Stanford University School of Medicine) ;
Headley, Colwyn A. (Stanford University School of Medicine) ;
Tsao, Noah L. (University of Pennsylvania) ;
Gellatly, Corry (University of Leicester) ;
Zuber, Verena (Imperial College London) ;
Shen, Fred (University of Michigan) ;
Hornsby, Whitney E. (University of Michigan) ;
Laursen, Ina Holst (Copenhagen University Hospital-Rigshospitalet) ;
Verma, Shefali S. (Perelman School of Medicine) ;
Locke, Adam E. (Regeneron Genetics Center, LLC) ;
Einarsson, Gudmundur (deCODE genetics/Amgen Inc) ;
Thorleifsson, Gudmar (deCODE genetics/Amgen Inc) ;
Graham, Sarah E. (University of Michigan) ;
Dikilitas, Ozan (Mayo Clinic Rochester) ;
Pattee, Jack W. (University of Minnesota) ;
Judy, Renae L. (University of Pennsylvania) ;
Pauls-Verges, Ferran (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Nielsen, Jonas B. (Norwegian University of Science and Technology) ;
Wolford, Brooke N. (Norwegian University of Science and Technology) ;
Brumpton, Ben M. (Trondheim University Hospital) ;
Dilme, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Peypoch, Olga (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Juscafresa, Laura Calsina (Parc de Salut MAR de Barcelona) ;
Edwards, Todd L. (Vanderbilt University Medical Center) ;
Li, Dadong (Regeneron Genetics Center, LLC) ;
Banasik, Karina (University of Copenhagen) ;
Brunak, Søren (University of Copenhagen) ;
Jacobsen, Rikke L. (Copenhagen University Hospital-Rigshospitalet) ;
Garcia-Barrio, Minerva T. (University of Michigan) ;
Zhang, Jifeng (University of Michigan) ;
Rasmussen, Lars M. (Odense University Hospital) ;
Lee, Regent (University of Oxford) ;
Handa, Ashok (University of Oxford) ;
Wanhainen, Anders (Umeå University) ;
Mani, Kevin (Uppsala University) ;
Lindholt, Jes S (Odense University Hospital) ;
Obel, Lasse M. (Odense University Hospital) ;
Strauss, Ewa (Poznan University of Medical Sciences) ;
Oszkinis, Grzegorz (University of Opole) ;
Nelson, Christopher P. (University of Leicester) ;
Saxby, Katie L. (University of Leicester) ;
van Herwaarden, Joost A. (Utrecht University) ;
van der Laan, Sander W (Utrecht University) ;
van Setten, Jessica (Utrecht University) ;
Camacho, Mercedes (Institut d'Investigació Biomèdica Sant Pau) ;
Davis, Frank M. (University of Michigan) ;
Wasikowski, Rachael (University of Michigan Medical School) ;
Tsoi, Lam C. (University of Michigan Medical School) ;
Gudjonsson, Johann E. (University of Michigan Medical School) ;
Eliason, Jonathan L. (University of Michigan) ;
Coleman, Dawn M. (University of Michigan) ;
Henke, Peter K. (University of Michigan) ;
Ganesh, Santhi K. (University of Michigan) ;
Chen, Y. Eugene (University of Michigan) ;
Guan, Weihua (University of Minnesota) ;
Pankow, James S (University of Minnesota) ;
Pankratz, Nathan (University of Minnesota) ;
Pedersen, Ole B. (University of Copenhagen) ;
Erikstrup, Christian (Aarhus University Hospital) ;
Tang, Weihong (University of Minnesota) ;
Hveem, Kristian (Nord-Trøndelag Hospital Trust) ;
Gudbjartsson, Daniel F (University of Iceland) ;
Gretarsdottir, Solveig (deCODE genetics/Amgen Inc) ;
Thorsteinsdottir, Unnur (University of Iceland) ;
Holm, Hilma (deCODE genetics/Amgen Inc) ;
Stefánsson, Kári (University of Iceland) ;
Ferreira, Manuel A. (Regeneron Genetics Center, LLC) ;
Baras, Aris (Regeneron Genetics Center, LLC) ;
Kullo, Iftikhar J. (Mayo Clinic Rochester) ;
Ritchie, Marylyn D. (University of Pennsylvania) ;
Christensen, Alex H. (Copenhagen University Hospital) ;
Iversen, Kasper K. (Copenhagen University Hospital) ;
Eldrup, Nikolaj (Copenhagen University Hospital-Rigshospitalet) ;
Sillesen, Henrik (University of Copenhagen) ;
Ostrowski, Sisse R. (University of Copenhagen) ;
Bundgaard, Henning (Copenhagen University Hospital-Rigshospitalet) ;
Ullum, Henrik (Statens Serum Institut) ;
Burgess, Stephen (University of Cambridge) ;
Gill, Dipender (Research and Early Development, Novo Nordisk) ;
Gallagher, Katherine (University of Michigan) ;
Sabater-Lleal, Maria (Karolinska Institutet) ;
Surakka, Ida (University of Michigan) ;
Jones, Gregory T. (University of Otago) ;
Bown, Matthew J. (University of Leicester) ;
Tsao, Philip S. (Stanford University School of Medicine) ;
Willer, Cristen J. (University of Michigan) ;
Damrauer, Scott M. (University of Pennsylvania) ;
Universitat Autònoma de Barcelona
Abdominal aortic aneurysm (AAA) is a common disease with substantial heritability. In this study, we performed a genome-wide association meta-analysis from 14 discovery cohorts and uncovered 141 independent associations, including 97 previously unreported loci. [...]
2023 -  10.1038/s41588-023-01510-y
Nature genetics, Vol. 55 (october 2023) , p. 1831-1842
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19 p, 2.4 MB |
Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations
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Temprano Sagrera, Gerard (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Sitlani, Collen M. (University of Washington) ;
Bone, William P. (University of Pennsylvania) ;
Martín Bórnez, Miguel (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Voight, Benjamin (University of Pennsylvania Perelman School of Medicine) ;
Morrison, Alanna (The University of Texas Health Science Center at Houston. Department of Epidemiology, Human Genetics, and Environmental Sciences) ;
Damrauer, Scott M. (University of Pennsylvania) ;
de Vries, Paul S. (The University of Texas Health Science Center at Houston. Department of Epidemiology, Human Genetics, and Environmental Sciences) ;
Smith, Nicholas L. (University of Washington. Department of Epidemiology, Human Genetics, and Environmental Sciences) ;
Sabater-Lleal, Maria (Institut d'Investigació Biomèdica Sant Pau) ;
Dehghan, Abbas ;
Heath, Adam S. ;
Reiner, Alex P. ;
Johnson, Andrew ;
Richmond, Anne ;
Peters, Annette ;
van Hylckama Vlieg, Astrid ;
McKnight, Barbara ;
Psaty, Bruce M. ;
Hayward, Caroline ;
Ward-Caviness, Cavin ;
O'Donnell, Cristopher ;
Chasman, Daniel ;
Strachan, David P. ;
Tregouet, David A. ;
Mook-Kanamori, Dennis ;
Gill, Dipender ;
Thibord, Florian ;
Asselbergs, Folkert W. ;
Leebeek, Frank W. G. ;
Rosendaal, Frits R. ;
Davies, Gail ;
Homuth, Georg ;
Temprano Sagrera, Gerard ;
Campbell, Harry ;
Taylor, Herman A. ;
Bressler, Jan ;
Huffman, Jennifer E. ;
Rotter, Jerome I. ;
Yao, Jie ;
Wilson, James F. ;
Bis, Joshua C. ;
Hahn, Julie M. ;
Desch, Karl C. ;
Wiggins, Kerri L. ;
Raffield, Laura M. ;
Bielak, Lawrence F. ;
Yanek, Lisa R. ;
Kleber, Marcus E. ;
Mueller, Martina ;
Kavousi, Maryam ;
Mangino, Massimo ;
Liu, Melissa ;
Brown, Michael R. ;
Conomos, Matthew P. ;
Jhun, Min-A. ;
Chen, Ming-Huei ;
de Maat, Moniek P. M. ;
Pankratz, Nathan ;
Smith, Nicholas L. ;
Peyser, Patricia A. ;
Elliot, Paul ;
Wei, Peng ;
Wild, Philipp S. ;
Morange, Pierre E. ;
van der Harst, Pim ;
Yang, Qiong ;
Le, Ngoc-Quynh ;
Marioni, Riccardo ;
Li, Ruifang ;
Damrauer, Scott M. ;
Cox, Simon R. ;
Trompet, Stella ;
Felix, Stephan B. ;
Völker, Uwe ;
Tang, Weihong ;
Koenig, Wolfgang ;
Jukema, J. Wouter ;
Guo, Xiuqing ;
Lindstrom, Sara ;
Wang, Lu ;
Smith, Erin N. ;
Gordon, William ;
van Hylckama Vlieg, Astrid ;
de Andrade, Mariza ;
Brody, Jennifer A. ;
Pattee, Jack W. ;
Haessler, Jeffrey ;
Brumpton, Ben M. ;
Suchon, Pierre ;
Chen, Ming-Huei ;
Turman, Constance ;
Germain, Marine ;
Wiggins, Kerri L. ;
MacDonald, James ;
Braekkan, Sigrid K. ;
Armasu, Sebastian M. ;
Pankratz, Nathan ;
Jackson, Rabecca D. ;
Nielsen, Jonas B. ;
Giulianini, Franco ;
Puurunen, Marja K. ;
Ibrahim, Manal ;
Heckbert, Susan R. ;
Bammler, Theo K. ;
Frazer, Kelly A. ;
McCauley, Bryan M. ;
Taylor, Kent ;
Pankow, James S. ;
Reiner, Alexander P. ;
Gabrielsen, Maiken E. ;
Deleuze, Jean-François ;
O'Donnell, Chris J. ;
Kim, Jihye ;
McKnight, Barbara ;
Kraft, Peter ;
Hansen, John-Bjarne ;
Rosendaal, Frits R. ;
Heit, John A. ;
Psaty, Bruce M. ;
Tang, Weihong ;
Kooperberg, Charles ;
Hveem, Kristian ;
Ridker, Paul M. ;
Morange, Pierre-Emmanuel ;
Johnson, Andrew D. ;
Kabrhel, Christopher ;
Trégouët, David-Alexandre ;
Smith, Nicholas L. ;
Malik, Rainer ;
Chauhan, Ganesh ;
Traylor, Matthew ;
Sargurupremraj, Muralidharan ;
Okada, Yukinori ;
Mishra, Aniket ;
Rutten-Jacobs, Loes ;
Giese, Anne-Katrin ;
van der Laan, Sander W. ;
Gretarsdottir, Solveig ;
Anderson, Christopher D. ;
Chong, Michael ;
Adams, Hieab HH. ;
Ago, Tetsuro ;
Almgren, Peter ;
Amouyel, Philippe (Institut Pasteur de Lille) ;
Ay, Hakan ;
Bartz, Traci M. ;
Benavente, Oscar R. ;
Bevan, Steve ;
Boncoraglio, Giorgio B. ;
Brown, Robert D. ;
Butterworth, Aadam S. ;
Carrera, Caty ;
Carty, Cara L. ;
Chen, Wei-Min ;
Cole, John W. ;
Correa, Adolfo ;
Cotlarciuc, Ioanna ;
Cruchaga, Carlos ;
Danesh, John ;
de Bakker, Paul I. W. ;
DeStefano, Anita L. ;
den Hoed, Marcel ;
Duan, Qing ;
Engelter, Stefan T. ;
Falcone, Guido J. ;
Gottesman, Rebecca F. ;
Grewal, Raji P. ;
Gudnason, Vilmundur (University of Iceland (Reykjavik, Islàndia)) ;
Gustafsson, Stefan ;
Haessler, Jeffrey ;
Harris, Tamara B. ;
Hassan, Ahamad ;
Havulinna, Aki S. ;
Heckbert, Susan R. ;
Holliday, Elizabeth G. ;
Howard, George ;
Hsu, Fang-Chi ;
Hyacinth, Hyacinth I. ;
Arfan Ikram, M. ;
Ingelsson, Erik ;
Irvin, Marguerite R. ;
Jian, Xueqiu ;
Jiménez-Conde, Jordi ;
Johnson, Julie A. ;
Jukema, J. Wouter ;
Kanai, Masahiro ;
Keene, Keith L. ;
Kissela, Brett M. ;
Kleindorfer, Dawn O. ;
Kooperberg, Charles ;
Kubo, Michiaki ;
Lange, Leslie A. ;
Langefeld, Carl D. ;
Langenberg, Claudia ;
Launer, Lenore J. ;
Lee, Jin-Moo ;
Lemmens, Robin ;
Leys, Didier ;
Lewis, Cathryn M. ;
Lin, Wei-Yu ;
Lindgren, Arne G. ;
Lorentzen, Erik ;
Magnusson, Patrik K. ;
Maguire, Jane ;
Manichaikul, Ani ;
McArdle, Patrick F. ;
Meschia, James F. ;
Mitchell, Braxton D. ;
Mosley, Thomas H. ;
Nalls, Michael A. ;
Ninomiya, Toshiharu ;
O'Donnell, Martin J. ;
Psaty, Bruce M. ;
Pulit, Sara L. ;
Rannikmäe, Kristiina ;
Reiner, Alexander P. ;
Rexrode, Kathryn M. ;
Rice, Kenneth ;
Rich, Stephen S. ;
Ridker, Paul M. ;
Rost, Natalia S. ;
Rothwell, Peter M. ;
Rotter, Jerome I. ;
Rundek, Tatjana ;
Sacco, Ralph L. ;
Sakaue, Saori ;
Sale, Michele M. ;
Salomaa, Veikko ;
Sapkota, Bishwa R. ;
Schmidt, Reinhold ;
Schmidt, Carsten O. ;
Schminke, Ulf ;
Sharma, Pankaj ;
Slowik, Agnieszka ;
Sudlow, Cathie L. M. ;
Tanislav, Christian ;
Tatlisumak, Turgut ;
Taylor, Kent D. ;
Thijs, Vincent N. S. ;
Thorleifsson, Gudmar ;
Thorsteinsdottir, Unnur ;
Tiedt, Steffen ;
Trompet, Stella ;
Tzourio, Christophe ;
van Duijn, Cornelia M. ;
Walters, Matthew ;
Wareham, Nicholas J. ;
Wassertheil-Smoller, Sylvia ;
Wilson, James G. ;
Wiggins, Kerri L. ;
Yang, Qiong ;
Yusuf, Salim ;
Amin, Najaf ;
Aparicio, Hugo S. ;
Arnett, Donna K. (University of Kentucky) ;
Attia, John ;
Beiser, Alexa S. ;
Berr, Claudine ;
Buring, Julie E. ;
Bustamante, Mariana ;
Caso, Valeria ;
Cheng, Yu-Ching ;
Hoan Choi, Seung ;
Chowhan, Ayesha ;
Cullell, Natalia (Fundacio Docència i Recerca MutuaTerrassa) ;
Dartigues, Jean-François ;
Delavaran, Hossein ;
Delgado, Pilar ;
Dörr, Marcus ;
Engström, Gunnar ;
Ford, Ian ;
Gurpreet, Wander S. ;
Hamsten, Anders ;
Heitsch, Laura ;
Hozawa, Aatsushi ;
Ibanez, Laura ;
Ilinca, Andrea ;
Ingelsson, Martin ;
Iwasaki, Motoki ;
Jackson, Rebecca D. ;
Jood, Katarina ;
Jousilahti, Pekka ;
Kaffashian, Sara ;
Kalra, Lalit ;
Kamouchi, Masahiro ;
Kitazono, Takanari ;
Kjartansson, Olafur ;
Kloss, Manja ;
Koudstaal, Peter J. ;
Krupinski, Jerzy ;
Labovitz, Daniel L. ;
Laurie, Cathy C. ;
Levi, Christhoper R. ;
Li, Linxin ;
Lind, Lars ;
Lindgren, Cecilia M. ;
Lioutas, Vasileios ;
Mei Liu, Yong ;
Lopez, Oscar L. ;
Makoto, Hirata ;
Martinez-Majander, Nicolas ;
Matsuda, Koichi ;
Minegishi, Naoko ;
Montaner, Joan ;
Morris, Andrew P. ;
Muiño, Elena ;
Müller-Nurasyid, Martina ;
Norrving, Bo ;
Ogishima, Soichi ;
Parati, Eugenio A. ;
Reddy Peddareddygari, Leema ;
Pedersen, Nancy L. ;
Pera, Joanna ;
Perola, Markus ;
Pezzini, Alessandro ;
Pileggi, Silvana ;
Rabionet, Raquel ;
Riba-Llena, Iolanda ;
Ribasés, Marta ;
Romero, Jose R. ;
Roquer, Jaume ;
Rudd, Anthony G. ;
Sarin, Antti-Pekka ;
Sarju, Ralhan ;
Sarnowski, Chloe ;
Sasaki, Makoto ;
Satizabal, Claudia L. ;
Satoh, Mamoru ;
Sattar, Naveed ;
Sawada, Norie ;
Sibolt, Gerli ;
Sigurdsson, Ásgeir ;
Smith, Albert ;
Sobue, Kenji ;
Soriano-Tárraga, Carolina ;
Stanne, Tara ;
Colin Stine, O. ;
Stott, David J. ;
Strauch, Konstantin ;
Takai, Takako ;
Tanaka, Hideo ;
Tanno, Kozo ;
Teumer, Alexander ;
Tomppo, Liisa ;
Torres-Aguila, Nuria P. ;
Touze, Emmanuel ;
Tsugane, Shoichiro ;
Uitterlinden, Aandre G. ;
Valdimarsson, Einar M. ;
van der Lee, Sven J. ;
Völzke, Henry ;
Wakai, Kenji ;
Weir, David ;
Williams, Stephen R. ;
Wolfe, Charles D.A. ;
Wong, Quenna ;
Xu, Huichun ;
Yamaji, Taiki ;
Sanghera, Dharambir K. ;
Melander, Olle ;
Jern, Christina ;
Strbian, Daniel ;
Fernandez-Cadenas, Israel ;
Longstreth, W.T. ;
Rolfs, Arndt ;
Hata, Jun ;
Woo, Daniel ;
Rosand, Jonathan ;
Pare, Guillaume ;
Hopewell, Jemma C. ;
Saleheen, Danish ;
Stefansson, Kari ;
Worrall, BradfordB. ;
Kittner, Steven J. ;
Seshadri, Sudha ;
Fornage, Myriam ;
Markus, Hugh S. ;
Howson, Joana M. M. ;
Kamatani, Yoichiro ;
Debette, Stephanie ;
Dichgans, Martin ;
Universitat Autònoma de Barcelona
Multi-phenotype analysis of genetically correlated phenotypes can increase the statistical power to detect loci associated with multiple traits, leading to the discovery of novel loci. This is the first study to date to comprehensively analyze the shared genetic effects within different hemostatic traits, and between these and their associated disease outcomes. [...]
2022 - 10.1111/jth.15698
Journal of Thrombosis and Haemostasis, Vol. 20 Núm. 6 (01 2022) , p. 1331-1349
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