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Simoctocog Alfa (Nuwiq) in Previously Untreated Patients with Severe Haemophilia A : Final Results of the NuProtect Study / Liesner, Ri J. (Great Ormond Street Hospital for Children (Londres)) ; Abraham, Aby (Christian Medical College (Vellore, India). Department of Hematology) ; Altisent, Carmen (Hospital Universitari Vall d'Hebron) ; Belletrutti, Mark J. (University of Alberta. Department of Pediatrics) ; Carcao, Manuel (Hospital for Sick Children (Toronto, Canada). Department of Paediatrics) ; Carvalho, Manuela (São João University Hospital Centre (Porto, Portugal)) ; Chambost, Hervé (Aix Marseille University. Department of Pediatric Hematology Oncology) ; Chan, Anthony K. C. (McMaster University. Division of Pediatric Hematology/Oncology) ; Dubey, Leonid (Western Ukrainian Specialized Children's Medical Centre. Department of Pediatrics) ; Ducore, Jonathan (University of California Davis Medical Center. Department of Pediatrics) ; Gattens, Michael (Cambridge University Hospitals NHS Foundation Trust (Regne Unit)) ; Gresele, Paolo (University of Perugia. Department of Medicine and Surgery) ; Gruel, Yves (Hôpital Trousseau (Tours, França)) ; Guillet, Benoit (Univ Rennes. Haemophilia Treatment Centre) ; Jimenez-Yuste, Victor (Hospital Universitario La Paz (Madrid)) ; Kitanovski, Lidija (University Medical Center Ljubljana. Department of Haemato-Oncology) ; Klukowska, Anna (Warsaw Medical University. Department of Pediatrics, Haematology and Oncology) ; Lohade, Sunil (Sahyadri Speciality Hospital. Department of Hematology) ; Mancuso, Maria Elisa (Humanitas Clinical and Research Center) ; Oldenburg, Johannes (University Clinic Bonn. Institute of Experimental Haematology and Transfusion Medicine) ; Pavlova, Anna (University Clinic Bonn. Institute of Experimental Haematology and Transfusion Medicine) ; Pollio, Berardino (Regina Margherita Children Hospital of Turin. Department of Transfusion Medicine) ; Sigaud, Marianne (CHU de Nantes) ; Vdovin, Vladimir (Morozovskaya Children's Hospital. Department of Hematology) ; Vilchevska, Kateryna (Institute of Urgent and Reconstructive Surgery named after V.K. Gusak of National Academy of Medical Sciences of Ukraine.Department of Hematology) ; Wu, John K. M. (British Columbia Children's Hospital (Vancouver, Canadà)) ; Jansen, Martina (Octapharma Pharmazeutika Produktionsges.mbH) ; Belyanskaya, Larisa (Octapharma AG) ; Walter, Olaf (Octapharma AG) ; Knaub, Sigurd (Octapharma AG) ; Neufeld, Ellis J. (St. Jude Children's Research Hospital (Memphis, Estats Units d'Amèrica))
Introduction FVIII inhibitor development is the most serious contemporary treatment complication in haemophilia A, particularly in previously untreated patients (PUPs). No inhibitors developed in clinical trials in previously treated patients treated with simoctocog alfa (Nuwiq), a fourth-generation recombinant FVIII produced in a human cell line. [...]
2021 - DOI (Digital Object Identifier)