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17 p, 3.3 MB A Molecular Basis for Selective Antagonist Destabilization of Dopamine D Receptor Quaternary Organization / Marsango, Sara (University of Glasgow) ; Caltabiano, Gianluigi 1978- (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; Jiménez-Rosés, Mireia (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; Millan, Mark J. (Institut de Recherches Servier, France) ; Pediani, John D. (University of Glasgow) ; Ward, Richard J. (University of Glasgow) ; Milligan, Graeme (University of Glasgow)
The dopamine D receptor (DR) is a molecular target for both first-generation and several recently-developed antipsychotic agents. Following stable expression of this mEGFP-tagged receptor, Spatial Intensity Distribution Analysis indicated that a substantial proportion of the receptor was present within dimeric/oligomeric complexes and that increased expression levels of the receptor favored a greater dimer to monomer ratio. [...]
2017 - 10.1038/s41598-017-02249-3
Scientific reports, Vol. 7 (may 2017)  

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