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Artículos, Encontrados 2 registros
Artículos Encontrados 2 registros  
1.
9 p, 536.9 KB Comparison of the efficacy and safety of FP-1201-lyo (intravenously administered recombinant human interferon beta-1a) and placebo in the treatment of patients with moderate or severe acute respiratory distress syndrome : Study protocol for a randomized controlled trial / Bellingan, Geoff (University College London Hospitals) ; Brealey, David (University College London Hospitals) ; Mancebo, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Mercat, Alain (CHU D'Angers) ; Patroniti, Nicolò (Azienda Ospedaliera San Gerardo) ; Pettilä, Ville (Helsinki University Hospital) ; Quintel, Michael (Universitätsmedizin Göttingen) ; Vincent, Jean-Louis (Université libre de Bruxelles) ; Maksimow, Mikael (Faron Pharmaceuticals Oy) ; Jalkanen, Markku (Faron Pharmaceuticals Oy) ; Piippo, Ilse (Faron Pharmaceuticals Oy) ; Ranieri, V.Marco (Sapienza University of Rome) ; Universitat Autònoma de Barcelona
Acute respiratory distress syndrome (ARDS) results in vascular leakage, inflammation and respiratory failure. There are currently no approved pharmacological treatments for ARDS and standard of care involves treatment of the underlying cause, and supportive care. [...]
2017 - 10.1186/s13063-017-2234-7
Trials, Vol. 18 Núm. 1 (13 2017) , p. 536  
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2.
8 p, 835.5 KB Study protocol of a randomised, double-blind, placebo-controlled, two-arm parallel-group, multi-centre phase 3 pivotal trial to investigate the efficacy and safety of recombinant human alkaline phosphatase for treatment of patients with sepsis-associated acute kidney injury / Pickkers, Peter (Nijmegen) ; Angus, Derek C (University of Pittsburgh School of Medicine) ; Arend, Jacques (AM-Pharma BV) ; Bellomo, Rinaldo (Austin Hospital) ; van den Berg, Erik (AM-Pharma BV) ; Bernholz, Juliane (AM-Pharma BV) ; Bestle, Morten (Copenhagen) ; Broglio, Kristine (Berry Consultants) ; Carlsen, Jan (AM-Pharma BV) ; Doig, Christopher J ; Ferrer, Ricard (Universitat Autònoma de Barcelona. Departament d'Infermeria) ; Joannidis, Michael (Medical University Innsbruck) ; Francois, Bruno (University of Limoges) ; Doi, Kent (The University of Tokyo Hospital) ; Kellum, John A ; Laterre, Pierre-François (Brussels) ; Liu, Kathleen (University of California San Fransisco) ; Mehta, Ravindra L (University of California) ; Murray, Patrick T (Dublin) ; Ostermann, Marlies (King's College London) ; Pettilä, Ville (Helsinki) ; Richards, Sharon (PHASTAR) ; Young, Paul (Wellington) ; Zarbock, Alexander (Universität Münster) ; Kjølbye, Anne Louise (AM-Pharma BV)
Sepsis, the leading cause of acute kidney injury (AKI), is associated with a high morbidity and mortality. Alkaline phosphatase (ALP) is an endogenous detoxifying enzyme. A recombinant human ALP compound, ilofotase alfa, showed no safety or tolerability concerns in a phase 2 trial. [...]
2023 - 10.1136/bmjopen-2022-065613
BMJ open, Vol. 13 (april 2023)  
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