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Cardiopoietic cell therapy for advanced ischaemic heart failure : results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial
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Bartunek, Jozef (Cardiovascular Center, Onze-Lieve-Vrouwziekenhuis OLV Hospital, Moorselbaan 164, Aalst, B-9300, Aalst, Belgium) ;
Terzic, Andre (Mayo Clinic, Center for Regenerative Medicine, Department of Cardiovascular Diseases, 200 First Street SW, Rochester, Minnesota 550905, USA) ;
Davison, Beth A. (Momentum Research, Inc, Durham, NC, USA) ;
Filippatos, Gerasimos S. (University General Hospital Attikon (Haidari, Grècia)) ;
Radovanovic, Slavica (University Hospital Center Bezanijska Kosa, Belgrade, Serbia) ;
Beleslin, Branko (University of Belgrade. Cardiology Clinic) ;
Merkely, Bela (Semmelweis University. Heart and Vascular Center) ;
Musialek, Piotr (Jagiellonian University Department of Cardiac and Vascular Diseases, John Paul II Hospital, Krakow, Poland) ;
Wojakowski, Wojciech (Third Division of Cardiology, Medical University of Silesia, Katowice, Poland) ;
Andreka, Peter (Gottsegen Gyorgy Hungarian Institute of Cardiology, Budapest, Hungary) ;
Horvath, Ivan G. (Heart Institute, University of Pécs, Pécs, Hungary) ;
Katz, Amos (Department of Cardiology, Barzilai Medical Center, Israel Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel) ;
Dolatabadi, Dariouch (Division of Cardiology, Centre Hospitalier Universitaire de Charleroi, Charleroi, Belgium) ;
El Nakadi, Badih (Division of Cardiology, Centre Hospitalier Universitaire de Charleroi, Charleroi, Belgium) ;
Arandjelovic, Aleksandra (Cardiology Department, Clinical Hospital Zvezdara, Belgrade, Serbia) ;
Edes, Istvan (Department of Cardiology, University of Debrecen, Debrecen, Hungary) ;
Seferovic, Petar M. (University of Belgrade School of Medicine, Belgrade University Medical Center, Belgrade, Serbia) ;
Obradovic, Slobodan (Clinic of Emergency Medicine, Military Medical Academy, School of Medicine, University of Defense, Belgrade, Serbia) ;
Vanderheyden, Marc (Cardiovascular Center, Onze-Lieve-Vrouwziekenhuis OLV Hospital, Moorselbaan 164, Aalst, B-9300, Aalst, Belgium) ;
Jagic, Nikola (Clinical Center Kragujevac, Kragujevac, Serbia) ;
Petrov, Ivo (Department of Cardiology, Angiology, and Electrophysiology, City Clinic Heart and Vascular Institute, Sofia University, Sofia, Bulgaria) ;
Atar, Shaul (Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel) ;
Halabi, Majdi (Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel) ;
Gelev, Valeri L. (Department of Cardiology, Angiology, and Electrophysiology, City Clinic Heart and Vascular Institute, Sofia University, Sofia, Bulgaria) ;
Shochat, Michael K. (Heart Institute, Hillel Yaffe Medical Center, Hadera, Rappaport School of Medicine, Haifa, Israel, Technion) ;
Kasprzak, Jaroslaw D. (Medical University of Lodz) ;
Sanz-Ruiz, Ricardo (Hospital General Universitario Gregorio Marañón) ;
Heyndrickx, Guy R. (Cardiovascular Center, Onze-Lieve-Vrouwziekenhuis OLV Hospital, Moorselbaan 164, Aalst, B-9300, Aalst, Belgium) ;
Nyolczas, Noémi (Medical Centre, Hungarian Defense Forces, Budapest, Hungary) ;
Legrand, Victor (Department of Cardiology, Centre Hospitalier Universitaire de Liège, Liège, Belgium) ;
Guédès, Antoine (Department of Cardiology, Universite Catholique de Louvain, CHU UcL Namur, Yvoir, Belgium) ;
Heyse, Alex (Department of Cardiology, AZ Glorieux, Ronse, Belgium) ;
Moccetti, Tiziano (Cardiocentro Ticino, Lugano, Switzerland) ;
Fernandez Aviles, Francesc (Hospital General Universitario Gregorio Marañón) ;
Jimenez-Quevedo, Pilar (Hospital Clínico San Carlos (Madrid)) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hernandez-Garcia, Jose Maria (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Ribichini, Flavio (Department of Cardiology, University of Verona, Italy) ;
Gruchala, Marcin (Department of Cardiology, Medical University of Gdansk, Gdansk, Poland) ;
Waldman, Scott A. (Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA) ;
Teerlink, John R. (School of Medicine, University of California San Francisco and Section of Cardiology, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA) ;
Gersh, Bernard J. (Mayo Clinic, Center for Regenerative Medicine, Department of Cardiovascular Diseases, 200 First Street SW, Rochester, Minnesota 550905, USA) ;
Povsic, Thomas J. (Duke Clinical Research Institute and Duke Medicine, Durham, NC, USA) ;
Henry, Timothy D. (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ;
Metra, Marco (Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University and Spedali Civili, Brescia, Italy) ;
Hajjar, Roger J. (Mount Sinai School of Medicine, New York, NY, USA) ;
Tendera, Michal (Third Division of Cardiology, Medical University of Silesia, Katowice, Poland) ;
Behfar, Atta (Mayo Clinic, Center for Regenerative Medicine, Department of Cardiovascular Diseases, 200 First Street SW, Rochester, Minnesota 550905, USA) ;
Alexandre, Bertrand (Celyad, Mont Saint Guibert, Belgium) ;
Seron, Aymeric (Celyad, Mont Saint Guibert, Belgium) ;
Stough, Wendy Gattis (Departments of Clinical Research and Pharmacy Practice, Campbell University College of Pharmacy and Health Sciences, Cary, NC, USA) ;
Sherman, Warren (Celyad, Mont Saint Guibert, Belgium) ;
Cotter, Gad (Momentum Research, Inc, Durham, NC, USA) ;
Wijns, William (The Lambe Institute for Translational Medicine and Curam, National University of Ireland Galway and Saolta University Healthcare Group, Galway, Ireland) ;
Universitat Autònoma de Barcelona
Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed to validate cardiopoiesis-based biotherapy in a larger heart failure cohort. [...]
2016 -  10.1093/eurheartj/ehw543
European heart journal, Vol. 38 (december 2016) , p. 648-660
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