|
1.
|
|
26 p, 2.2 MB |
Inherited human ezrin deficiency impairs adaptive immunity
/
García-Solís, Blanca (Hospital Universitario La Paz (Madrid)) ;
Van Den Rym, Ana (Hospital Universitario La Paz (Madrid)) ;
Martinez-Martinez, Laura (Institut d'Investigació Biomèdica Sant Pau) ;
Franco-Leyva, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
Pérez-Caraballo, Jareb J. (Vanderbilt University Medical Center) ;
Markle, Janet (Vanderbilt University Medical Center) ;
Cubillos-Zapata, Carolina (Centre for Biomedical Research Network) ;
Marín, Ana V. (Centro de investigación Hospital Universitario 12 de Octubre) ;
Recio, María J. (Centro de investigación Hospital Universitario 12 de Octubre) ;
Regueiro, José R. (Centro de investigación Hospital Universitario 12 de Octubre) ;
Navarro-Zapata, Alfonso (Hospital Universitario La Paz (Madrid)) ;
Mestre-Durín, Carmen (Hospital Universitario La Paz (Madrid)) ;
Ferreras, Cristina (Hospital Universitario La Paz (Madrid)) ;
Cotázar, Carla Martín (Hospital Universitario La Paz (Madrid)) ;
Mena, Roció (Hospital Universitario La Paz (Madrid)) ;
de la Calle-Fabregat, Carlos (Institut d'Investigació contra la Leucèmia Josep Carreras) ;
López-Lera, Alberto (Hospital Universitario La Paz (Madrid)) ;
Arquero, Miguel Fernández (Hospital Clínico San Carlos (Madrid)) ;
Pérez-Martínez, Antonio (Hospital Universitario La Paz (Madrid)) ;
López-Collazo, Eduardo (Hospital Universitario La Paz (Madrid)) ;
Sánchez-Ramón, Silvia (Hospital Clínico San Carlos (Madrid)) ;
Casanova, Jean-Laurent (Howard Hughes Medical Institute) ;
Martínez-Barricarte, Rubén (Vanderbilt University Medical Center) ;
de la Calle-Martín, Oscar (Institut d'Investigació Biomèdica Sant Pau) ;
de Diego, Rebeca Pérez (Hospital Universitario La Paz (Madrid)) ;
Universitat Autònoma de Barcelona
Inborn errors of immunity (IEI) are a group of monogenic diseases that confer susceptibility to infection, autoimmunity, and cancer. Despite the life-threatening consequences of some IEI, their genetic cause remains unknown in many patients. [...]
2023 -  10.1016/j.jaci.2023.05.022
The Journal of Allergy and Clinical Immunology, Vol. 152 (june 2023) , p. 997-1009.e11
|
|
|
2.
|
|
9 p, 3.8 MB |
Zinc-Assisted Microscale Granules Made of the SARS-CoV-2 Spike Protein Trigger Neutralizing, Antivirus Antibody Responses
/
de Pinho Favaro, Marianna T (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Álamo, Patricia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Roher Armentia, Nerea (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Chillón Rodríguez, Miguel (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Lascorz Lozano, Jara A (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Márquez, Merce (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Corchero Nieto, José Luis (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Mendoza, Rosa (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Martínez-Torró, Carlos (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ferrer-Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Ferreira, Luis (Universidade de São Paulo) ;
Mangues, Ramon 1957- (Institut d'Investigació Biomèdica Sant Pau) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Parladé Molist, Eloi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Universitat Autònoma de Barcelona.
SGR - Bio-fàrmacs innovadors
The development of new and more efficient vaccination approaches is a constant need, due to the pressure of historical and emerging infectious diseases and the limited efficacy and universality of the current vaccination technologies. [...]
2024 - 10.1021/acsmaterialslett.3c01643
ACS materials letters, Vol. 6, Issue 3 (February 2024) , p. 954-962
|
|
|
3.
|
|
|
4.
|
|
8 p, 3.0 MB |
Association of Serum Ferritin Levels Before Start of Conditioning With Mortality After alloSCT - A Prospective, Non-interventional Study of the EBMT Transplant Complications Working Party
/
Penack, Olaf (Charité - Universitätsmedizin Berlin) ;
Peczynski, Christophe (EBMT Statistical Unit) ;
van der Werf, Steffie (EBMT Data Office) ;
Finke, Jürgen (University of Freiburg) ;
Ganser, Arnold (Hannover Medical School) ;
Schoemans, Helene (University Hospitals Leuven (Bèlgica)) ;
Pavlu, Jiri (Imperial College London) ;
Niittyvuopio, Riitta (HUCH Comprehensive Cancer Center) ;
Schroyens, W.ilfried (University Hospital Antwerp (Bèlgica)) ;
Kaynar, Leylagül (Erciyes University) ;
Blau, Igor W. (Department of Hematology. Oncology. and Tumor Immunology) ;
van der Velden, Walter J.F.M. (Radboud University) ;
Malouf Sierra, Jorge 1971- (Institut d'Investigació Biomèdica Sant Pau) ;
Cortelezzi, Agostini (University of Milan) ;
Wulf, Gerald (Universitätsklinikum Göttingen) ;
Turlure, Pascal (CHRU Limoges) ;
Rovira Argelagués, Montserrat (Hospital Clínic i Provincial de Barcelona) ;
Ozkurt, Zubeydenur (Gazi University) ;
Pascual-Cascon, Maria J. (Hospital Regional Universitario de Málaga) ;
Moreira, Maria C. (Instituto National do Cancer) ;
Clausen, Johannes (Ordensklinikum Linz Elisabethinen) ;
Greinix, Hildegard (Medical University of Graz) ;
Duarte, Rafael F. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Basak, Grzegorz (Medical University of Warsaw) ;
Universitat Autònoma de Barcelona
Elevated serum ferritin levels occur due to iron overload or during inflammation and macrophage activation. A correlation of high serum ferritin levels with increased mortality after alloSCT has been suggested by several retrospective analyses as well as by two smaller prospective studies. [...]
2020 - 10.3389/fimmu.2020.00586
Frontiers in immunology, Vol. 11 (15 2020) , p. 586
|
|
|
5.
|
|
9 p, 1.2 MB |
BCG vaccination to reduce the impact of COVID-19 in healthcare workers : Protocol for a randomised controlled trial (BRACE trial)
/
Pittet, Laure F (The Royal Children's Hospital Melbourne) ;
Messina, Nicole L (The University of Melbourne) ;
Gardiner, Kaya (Murdoch Children's Research Institute) ;
Orsini, Francesca (Murdoch Children's Research Institute) ;
Abruzzo, Veronica (Murdoch Children's Research Institute) ;
Bannister, Samantha (The Royal Children's Hospital Melbourne) ;
Bonten, Marc (Julius Center for Health Sciences and Primary Care) ;
Campbell, John L (University of Exeter Medical School) ;
Croda, Julio (Yale School of Public Health) ;
Dalcolmo, Margareth (Pontifical Catholic University of Rio de Janeiro) ;
Elia, Sonja (The Royal Children's Hospital Melbourne) ;
Germano, Susie (Murdoch Children's Research Institute) ;
Goodall, Casey (Murdoch Children's Research Institute) ;
Gwee, Amanda (The Royal Children's Hospital Melbourne) ;
Jamieson, Tenaya (Murdoch Children's Research Institute) ;
Jardim, Bruno (Fundação de Medicina Tropical Doutor Heitor Vieira Dourado) ;
Kollmann, Tobias R (Telethon Kids Institute) ;
Guimarães Lacerda, Marcus Vinícius (Fundação Oswaldo Cruz (Brasil)) ;
Lee, Katherine J (Murdoch Children's Research Institute) ;
Legge, Donna (Royal Children's Hospital Melbourne) ;
Lucas, Michaela (The University of Western Australia) ;
Lynn, David J (Flinders University) ;
McDonald, Ellie (Murdoch Children's Research Institute) ;
Manning, Laurens (Fiona Stanley Hospital (Perth, Austràlia)) ;
Munns, Craig F (The University of Sydney) ;
Perrett, Kirsten P (Murdoch Children's Research Institute) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Richmond, Peter (The University of Western Australia) ;
Shann, Frank (The Royal Children's Hospital Melbourne) ;
Sudbury, Eva (Murdoch Children's Research Institute) ;
Villanueva, Paola (The University of Melbourne) ;
Wood, Nicholas J (National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases) ;
Lieschke, Katherine (Murdoch Children's Research Institute) ;
Subbarao, Kanta (The Peter Doherty Institute for Infection and Immunity) ;
Davidson, Andrew (Murdoch Children's Research Institute) ;
Curtis, Nigel (The Royal Children's Hospital Melbourne) ;
Universitat Autònoma de Barcelona
BCG vaccination modulates immune responses to unrelated pathogens. This off-target effect could reduce the impact of emerging pathogens. As a readily available, inexpensive intervention that has a well-established safety profile, BCG is a good candidate for protecting healthcare workers (HCWs) and other vulnerable groups against COVID-19. [...]
2021 - 10.1136/bmjopen-2021-052101
BMJ open, Vol. 11 (october 2021)
|
|
|
6.
|
|
25 p, 2.7 MB |
Preclinical evaluation of PHH-1V vaccine candidate against SARS-CoV-2 in non-human primates
/
Prenafeta, Antoni (HIPRA) ;
Bech-Sàbat, Gregori (HIPRA) ;
Moros, Alexandra (HIPRA) ;
Barreiro, Antonio (HIPRA) ;
Fernández, Alex (HIPRA) ;
Cañete, Manuel (HIPRA) ;
Roca, Mercè (HIPRA) ;
González-González, Luis (HIPRA) ;
Garriga, Carme (HIPRA) ;
Confais, Joachim (Cynbiose) ;
Toussenot, Marion (Cynbiose) ;
Contamin, Hugues (Cynbiose) ;
Pizzorno, Andrés (Université de Lyon. Centre International de Recherche en Infectiologie) ;
Rosa-Calatrava, Manuel (Université de Lyon) ;
Pradenas, Edwards (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Marfil, Sílvia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Blanco, Julià (Universitat de Vic - Universitat Central de Catalunya) ;
Rica, Paula Cebollada (Universitat Pompeu Fabra) ;
Sisteré-Oró, Marta (Universitat Pompeu Fabra) ;
Meyerhans, Andreas (Institució Catalana de Recerca i Estudis Avançats) ;
Lorca, Cristina (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Segalés Coma, Joaquim (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Prat, Teresa (HIPRA) ;
March, Ricard (HIPRA) ;
Ferrer, Laura (HIPRA)
SARS-CoV-2 emerged in December 2019 and quickly spread worldwide, continuously striking with an unpredictable evolution. Despite the success in vaccine production and mass vaccination programs, the situation is not still completely controlled, and therefore accessible second-generation vaccines are required to mitigate the pandemic. [...]
2023 - 10.1016/j.isci.2023.107224
iScience, Vol. 26 (june 2023)
|
|
|
7.
|
|
15 p, 1.4 MB |
Critical role of interleukin (IL)-17 in inflammatory and immune disorders : An updated review of the evidence focusing in controversies
/
Ruiz de Morales, José María G. (Universidad de León) ;
Puig, Lluís (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Daudén, Esteban (Hospital Universitario de la Princesa (Madrid)) ;
Cañete, Juan D. (Hospital Clínic i Provincial de Barcelona) ;
Pablos, José Luis (Hospital Universitario 12 de Octubre (Madrid)) ;
Martín, Antonio Oliveira (Hospital Universitario La Paz (Madrid)) ;
Juanatey, Carlos González (Hospital Universitario Lucus Augusti (Lugo)) ;
Adan Civera, Alfredo (Hospital Clínic i Provincial de Barcelona) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Borruel, Natalia (Hospital Universitari Vall d'Hebron) ;
Ortí, Guillermo (Vall d'Hebron Institut d'Oncologia) ;
Holgado-Martín, Esther (Ruber Internacional) ;
Garcia-Vidal, Carolina (Hospital Clínic i Provincial de Barcelona) ;
Vizcaya-Morales, Cynthia (Novartis Pharma) ;
Martín-Vázquez, Víctor (Novartis Farmacéutica) ;
González-Gay, Miguel Ángel (Universidad de Cantabria)
Interleukin 17 (IL-17) is a proinflammatory cytokine that has been the focus of intensive research because of its crucial role in the pathogenesis of different diseases across many medical specialties. [...]
2020 - 10.1016/j.autrev.2019.102429
Autoimmunity Reviews, Vol. 19 Núm. 1 (january 2020) , p. 102429
|
|
|
8.
|
|
28 p, 4.0 MB |
Mycobacterium manresensis induces trained immunity in vitro
/
de Homdedeu, Miquel (Hospital Universitari Vall d'Hebron) ;
Sanchez-Moral, Lidia (Institut Germans Trias i Pujol) ;
Violán, Concepció (Universitat Autònoma de Barcelona) ;
Ràfols, Neus (Institut Germans Trias i Pujol) ;
Ouchi, Dan (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Martín, Berta (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Peinado, Miguel A. (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Rodriguez-Cortes, Alheli (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Arch Sisquella, Marta (Institut Germans Trias i Pujol) ;
Perez-Zsolt, Daniel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Muñoz-Basagoiti, Jordana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Izquierdo Useros, Nuria (Centre for Biomedical Research on Infectious Diseases) ;
Salvador, Betlem (Jordi Gol University Research Institute in Primary Care) ;
Matllo, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
López-Serrano, Sergi (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Segalés Coma, Joaquim (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Vilaplana, Cristina (Direcció Clínica Territorial de Malalties Infeccioses i Salut Internacional de Gerència Territorial Metropolitana Nord) ;
Torán-Montserrat, Pere (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Morros, Rosa (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Monfà, Ramon (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Sarrias, Maria-Rosa (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Cardona, Pere-Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
The COVID-19 pandemic posed a global health crisis, with new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants weakening vaccine-driven protection. Trained immunity could help tackle COVID-19 disease. [...]
2023 - 10.1016/j.isci.2023.106873
iScience, Vol. 26 (may 2023) , p. 106873
|
|
|
9.
|
|
9 p, 608.1 KB |
Characterisation of the safety profile of evobrutinib in over 1000 patients from phase II clinical trials in multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus : an integrated safety analysis
/
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Wallace, Daniel (University of California) ;
Genovese, Mark C. (Stanford University) ;
Tomic, Davorka Lucia (Ares Trading SA) ;
Parsons-Rich, Dana (EMD Serono Research & Development Institute) ;
Le Bolay, Claire (Merck Healthcare KGaA) ;
Kao, Amy H. (EMD Serono Research & Development Institute) ;
Guehring, Hans (Merck Healthcare KGaA) ;
Universitat Autònoma de Barcelona
Objective Analyse the integrated safety profile of evobrutinib, a Bruton's tyrosine kinase inhibitor (BTKi), using pooled data from multiple sclerosis (MS), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) trials. [...]
2022 - 10.1136/jnnp-2022-328799
Journal of Neurology, Neurosurgery, and Psychiatry, Vol. 94 Núm. 1 (2022) , p. 1-9
|
|
|
10.
|
|
10 p, 1.3 MB |
Coordinated local RNA overexpression of complement induced by interferon gamma in myositis
/
Casal-Dominguez, Maria (Johns Hopkins University School of Medicine) ;
Pinal-Fernandez, Iago (Johns Hopkins University School of Medicine) ;
Pak, Katherine (National Institute of Arthritis and Musculoskeletal and Skin Diseases) ;
Muñoz-Braceras, Sandra (National Institute of Arthritis and Musculoskeletal and Skin Diseases) ;
Milisenda, Jose C. (Hospital Clínic i Provincial de Barcelona) ;
Torres-Ruiz, Jiram (Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán) ;
Dell'Orso, Stefania (National Institute of Arthritis and Musculoskeletal and Skin Diseases) ;
Naz, Faiza (National Institute of Arthritis and Musculoskeletal and Skin Diseases) ;
Gutierrez-Cruz, Gustavo (National Institute of Arthritis and Musculoskeletal and Skin Diseases) ;
Duque-Jaimez, Yaiza (Hospital Clínic i Provincial de Barcelona) ;
Matas-Garcia, Ana (Hospital Clínic i Provincial de Barcelona) ;
Valls-Roca, Laura (Hospital Clínic i Provincial de Barcelona) ;
Garrabou, Glòria (Hospital Clínic i Provincial de Barcelona) ;
Trallero-Araguas, Ernesto (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Walitt, Brian (National Institute of Neurological Disorders and Stroke) ;
Christopher-Stine, Lisa (Johns Hopkins University School of Medicine) ;
Lloyd, Thomas E. (Johns Hopkins University School of Medicine) ;
Paik, Julie J. (Johns Hopkins University School of Medicine) ;
Albayda, Jemima (Johns Hopkins University School of Medicine) ;
Corse, Andrea (Johns Hopkins University School of Medicine) ;
Grau, Josep Maria (Hospital Clínic i Provincial de Barcelona) ;
Selva O'Callaghan, Albert (Universitat Autònoma de Barcelona) ;
Mammen, Andrew L. (Johns Hopkins University School of Medicine)
Complement proteins are deposited in the muscles of patients with myositis. However, the local expression and regulation of complement genes within myositis muscle have not been well characterized. In this study, bulk RNA sequencing (RNAseq) analyses of muscle biopsy specimens revealed that complement genes are locally overexpressed and correlate with markers of myositis disease activity, including the expression of interferon-gamma (IFN γ)-induced genes. [...]
2023 - 10.1038/s41598-023-28838-z
Scientific reports, Vol. 13 (february 2023)
|
|
visitante ::
identificación
alerta personal vía correo electrónico o subscríbase al 
canal RSS.
