Esophagitis in a high H. pylori prevalence area : severe disease is rare but concomitant peptic ulcer is frequent
Ponce, Julio (Hospital Universitari i Politècnic La Fe (València))
Calvet Calvo, Xavier (Instituto de Salud Carlos III)
Gallach, Marta (Universitat Autònoma de Barcelona. Departament de Medicina)
Ponce Romero, Marta (Hospital Universitari i Politècnic La Fe (València))

Date:	2011
Abstract:	Background: Few data are available on the prevalence of erosive and severe esophagitis in Western countries. Objective: To retrospectively determine the prevalence and the factors predicting erosive esophagitis and severe esophagitis in a large series of endoscopies in Spain. Design: Retrospective observational study. A multivariate analysis was performed to determine variables predicting severe esophagitis. Setting: Databases of 29 Spanish endoscopy units. Patients: Patients submitted to a diagnostic endoscopy during the year 2005. Interventions: Retrospective review of the databases. Main Outcome Measurements: Esophagitis severity (graded according to the Los Angeles classification) and associated endoscopic findings. Results: Esophagitis was observed in 8. 7% of the 93,699 endoscopies reviewed. Severe esophagitis (LA grade C or D) accounted for 22. 5% of cases of the disease and was found in 1. 9% of all endoscopies. Incidences of esophagitis and those of severe esophagitis were 86. 2 and 18. 7 cases per 100,000 inhabitants per year respectively. Male sex (OR 1. 89) and advanced age (OR 4. 2 for patients in the fourth age quartile) were the only variables associated with severe esophagitis. Associated peptic ulcer was present in 8. 8% of cases. Limitations: Retrospective study, no data on individual proton pump inhibitors use. Conclusions: Severe esophagitis is an infrequent finding in Spain. It occurs predominantly in males and in older individuals. Peptic ulcer disease is frequently associated with erosive esophagitis.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; Versió publicada
Subject:	Úlcera pèptica ; Esophagitis ; Concomitant peptic ulcer
Published in:	PloS one, Vol. 6, Issue 10 (October 2011) , p. e25051, ISSN 1932-6203

DOI: 10.1371/journal.pone.0025051
PMID: 22022373

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