Web of Science: 11 citas, Scopus: 12 citas, Google Scholar: citas,
Regulatory role of vitamin D in T-cell reactivity against myelin peptides in relapsing-remitting multiple sclerosis patients
Grau López, Laia (Hospital Germans Trias i Pujol)
Martínez Cáceres, Eva María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Granada Ybern, María Luisa (Hospital Germans Trias i Pujol)
Raïch Regué, Dàlia (Institut Germans Trias i Pujol)
Naranjo Gómez, María del Mar (Institut Germans Trias i Pujol)
Borràs Serres, Francesc Enric (Institut Germans Trias i Pujol)
Ramo Tello, Cristina (Hospital Germans Trias i Pujol)

Fecha: 2012
Resumen: Background: Low levels of plasma 25-hydroxyvitaminD (25(OH)D) are associated with a higher incidence of multiple sclerosis (MS) due to the immune suppressive properties of vitamin D. The aim of this study was to determine the correlation between plasma 25(OH)D concentrations and clinical and immunological variables in a cohort of multiple sclerosis patients. Methods: Plasma 25(OH)D concentrations were evaluated in summer and winter in 15 primary progressive MS (PPMS) patients, 40 relapsing- remitting MS (RRMS) patients and 40 controls (HC). Protocol variables included demographic and clinical data, radiological findings and immunological variables (oligoclonal bands, HLADR15 and T-lymphocyte proliferation to a definite mix of 7 myelin peptides). Results: During the winter, plasma concentrations were significantly lower in RRMS patients compared to HC, whereas no differences were found in summer. No relationships were found between plasma 25(OH)D concentrations and clinical or radiological variables. RRMS patients with a positive T-cell proliferation to a mix of myelin peptides (n = 31) had lower 25(OH)D concentrations. Conclusions: 25(OH)D is an immunomodulatory molecule that might have a regulatory role in T-cell proliferation to myelin peptides in RRMS patients.
Derechos: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Lengua: Anglès.
Documento: article ; publishedVersion
Materia: Multiple sclerosis ; T-cell proliferation ; Vitamin D
Publicado en: BMC Neurology, Vol. 12, N. 103 (September 2012) , p. 1-6, ISSN 1471-2377

DOI: 10.1186/1471-2377-12-103
PMID: 23006125


6 p, 268.2 KB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Artículos > Artículos publicados

 Registro creado el 2013-10-25, última modificación el 2019-10-07



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