@article{ddd.uab.cat:113316,
      author = {Ovilo, Cristina) and Oliver, Àngels) and Noguera, José Luis
               and Clop, Alex and Barragán, Carmen) and Varona, Luis and
               Rodriguez, Carmen) and Toro, Miguel) and Sánchez Bonastre,
               Armando and Perez-Enciso, Miguel and Silió, Luis)},
       title = {Test for positional candidate genes for body composition on pig
               chromosome 6},
     journal = {Genetics, selection, evolution},
        year = {2002},
      volume = {34},
       pages = {465--479},
       month = {7},
    abstract = {One QTL affecting backfat thickness (BF), intramuscular fat
               content (IMF) and eye muscle area (MA) was previously localized
               on porcine chromosome 6 in an F2 cross between Iberian and
               Landrace pigs. This work was done to study the effect of two
               positional candidate genes on these traits: H-FABP and LEPR
               genes. The QTL mapping analysis was repeated with a regression
               method using genotypes for seven microsatellites and two PCR-
               RFLPs in the H-FABP and LEPR genes. H-FABP and LEPR genes were
               located at 85.4 and 107 cM respectively, by linkage analysis. The
               effects of the candidate gene polymorphisms were analyzed in two
               ways. When an animal model was fitted, both genes showed
               significant effects on fatness traits, the H-FABP polymorphism
               showed significant effects on IMF and MA, and the LEPR
               polymorphism on BF and IMF. But when the candidate gene effect
               was included in a QTL regression analysis these associations were
               not observed, suggesting that they must not be the causal
               mutations responsible for the effects found. Differences in the
               results of both analyses showed the inadequacy of the animal
               model approach for the evaluation of positional candidate genes
               in populations with linkage disequilibrium, when the
               probabilities of the parental origin of the QTL alleles are not
               included in the model.},
         doi = {10.1186/1297-9686-34-4-465},
         url = {https://ddd.uab.cat/record/113316},
}