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Complete genome of a European hepatitis C virus subtype 1g isolate : phylogenetic and genetic analyses
Bracho, María A. (Universitat de València. Institut "Cavanilles" de Biodiversitat i Biologia Evolutiva)
Saludes Montoro, Verónica (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Martró Català, Elisa (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Bargalló, Ana (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
González Candelas, Fernando (CIBER de Epidemiología y Salud Pública (CIBERESP))
Ausina Ruiz, Vicente (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)

Date: 2008
Abstract: Background: Hepatitis C virus isolates have been classified into six main genotypes and a variable number of subtypes within each genotype, mainly based on phylogenetic analysis. Analyses of the genetic relationship among genotypes and subtypes are more reliable when complete genome sequences (or at least the full coding region) are used; however, so far 31 of 80 confirmed or proposed subtypes have at least one complete genome available. Of these, 20 correspond to confirmed subtypes of epidemic interest. Results: We present and analyse the first complete genome sequence of a HCV subtype 1g isolate. Phylogenetic and genetic distance analyses reveal that HCV-1g is the most divergent subtype among the HCV-1 confirmed subtypes. Potential genomic recombination events between genotypes or subtype 1 genomes were ruled out. We demonstrate phylogenetic congruence of previously deposited partial sequences of HCV-1g with respect to our sequence. Conclusion: In light of this, we propose changing the current status of its subtype-specific designation from provisional to confirmed.
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: publishedVersion ; recerca
Published in: Virology journal, Vol. 5, Núm. 72 (June 2008), p. 1-7

DOI: 10.1186/1743-422X-5-72
PMID: 18533988


7 p, 281.9 KB

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Articles > Research articles
Articles > Published articles

 Record created 2013-12-02, last modified 2020-10-30



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