Pleiotrophin over-expression rescues dopaminergic neurons in parkinsonian rats
Taravini, Irene R. E. (Instituto de Investigaciones Farmacológicas (Buenos Aires, Argentina))
Chertoff, Mariela (Fundación Instituto Leloir (Buenos Aires, Argentina))
Cafferata, Eduardo G. (Fundación Instituto Leloir (Buenos Aires, Argentina))
Courty, José (Centre National de la Recherche Scientifique (França))
Murer, Mario G. (Universidad de Buenos Aires. Departamento de Fisiología y Biofísica)
Pitossi, Fernando J. (Fundación Instituto Leloir (Buenos Aires, Argentina))
Gershanik, Oscar S. (Instituto de Investigaciones Farmacológicas (Buenos Aires, Argentina))

Date:	2011
Abstract:	Background: Pleiotrophin is known to promote the survival and differentiation of dopaminergic neurons in vitro and is up-regulated in the substantia nigra of Parkinson's disease patients. To establish whether pleiotrophin has a trophic effect on nigrostriatal dopaminergic neurons in vivo, we injected a recombinant adenovirus expressing pleiotrophin in the substantia nigra of 6-hydroxydopamine lesioned rats. Results: The viral vector induced pleiotrophin over-expression by astrocytes in the substantia nigra pars compacta, without modifying endogenous neuronal expression. The percentage of tyrosine hydroxylase-immunoreactive cells as well as the area of their projections in the lesioned striatum was higher in pleiotrophin-treated animals than in controls. Conclusions: These results indicate that pleiotrophin over-expression partially rescues tyrosine hydroxylase-immunoreactive cell bodies and terminals of dopaminergic neurons undergoing 6-hydroxydopamine-induced degeneration.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; Versió publicada
Published in:	Molecular neurodegeneration, Vol. 6, N. 40 (June 2011) , p. 1-12, ISSN 1750-1326

DOI: 10.1186/1750-1326-6-40
PMID: 21649894

12 p, 1.1 MB

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