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Acoustic-like dynamics of amorphous drugs in the THz regime
Pogna, E. A. A. (Universitá di Roma ''La Sapienza'')
Rodríguez Tinoco, Cristian (Universitat Autònoma de Barcelona. Departament de Física)
Krisch, M. (European Synchrotron Radiation Facility)
Rodríguez Viejo, Javier (Universitat Autònoma de Barcelona. Departament de Física)
Scopigno, T. (Universitá di Roma ''La Sapienza'')

Date: 2013
Abstract: The high frequency dynamics of Indomethacin and Celecoxib glasses has been investigated by inelastic x-ray scattering, accessing a momentum-energy region still unexplored in amorphous pharmaceuticals. We find evidence of phonon-like acoustic dynamics, and determine the THz behavior of sound velocity and acoustic attenuation. Connections with ordinary sound propagation are discussed, along with the relation between fast and slow degrees of freedom as represented by non-ergodicity factor and kinetic fragility, respectively.
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; publishedVersion
Subject: Glasses ; Chemical physics ; Structure of solids and liquids
Published in: Scientific reports, Vol. 3, art. 2518 (August 2013) , ISSN 2045-2322

DOI: 10.1038/srep02518
PMID: 23989304


6 p, 579.9 KB

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Articles > Published articles

 Record created 2014-01-10, last modified 2019-09-25



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