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Single DNA molecule detection in an optical trap using surface-enhanced Raman scattering
Rao, Satish (Institut de Ciencies Fotòniques (Castelldefels, Catalunya))
Raj, Saurabh (Institut de Ciencies Fotòniques (Castelldefels, Catalunya))
Balint, Stefan (Institut de Ciencies Fotòniques (Castelldefels, Catalunya))
Bardina Fons, Carlota (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Campoy Sánchez, Susana (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Llagostera Casas, Montserrat (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Petrov, Dmitri (Institut de Ciencies Fotòniques (Castelldefels, Catalunya))
American Physical Society

Date: 2010
Abstract: Raman spectra from single DNA molecules in their natural aqueous environment are presented. A DNA molecule that is anchored between two optically trapped dielectric beads is suspended in a solution with nanosized silvercolloid particles. The nonspecific binding of the metal to the DNA enhances the Raman scattering that is excited by a near-infrared beam. A Raman spectrum is first recorded followed by a force-extension curve that verifies the presence of a single DNA molecule.
Rights: Tots els drets reservats.
Language: Anglès.
Document: article ; recerca ; publishedVersion
Subject: DNA ; Silver ; Colloidal systems ; Raman spectra ; Surface enhanced ; Raman scattering ; Metal surfaces ; Elasticity ; Metal optics ; Scattering measurements
Published in: Applied Physics Letters, Vol. 96, Issue 21 (May 2010) , p. 213701/1-213701/3, ISSN 1077-3118

DOI: 10.1063/1.3431628


4 p, 341.8 KB

The record appears in these collections:
Articles > Research articles
Articles > Published articles

 Record created 2014-02-18, last modified 2019-02-03



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