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Aggregation of liposomes induced by calcium : a structural and kinetic study
Roldán Vargas, Sándalo (Universidad de Granada. Departamento de Física Aplicada)
Martín Molina, Alberto (Universidad de Granada. Departamento de Física Aplicada)
Quesada Pérez, Manuel (Universidad de Jaén. Departamento de Física)
Barnadas Rodríguez, Ramon (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Estelrich, Joan (Universitat de Barcelona. Unitat de Fisicoquímica)
Callejas Fernández, José (Universidad de Granada. Departamento de Física Aplicada)

Fecha: 2007
Resumen: In this work, the calcium-induced aggregation of phosphatidylserine liposomes is probed by means of the analysis of the kinetics of such process as well as the aggregate morphology. This novel characterization of liposome aggregation involves the use of static and dynamic light-scattering techniques to obtain kinetic exponents and fractal dimensions. For salt concentrations larger than 5mM, a diffusion-limited aggregation regime is observed and the Brownian kernel properly describes the time evolution of the diffusion coefficient. For slow kinetics, a slightly modified multiple contact kernel is required. In any case, a time evolution model based on the numerical resolution of Smoluchowski’s equation is proposed in order to establish a theoretical description for the aggregating system. Such a model provides an alternative procedure to determine the dimerization constant, which might supply valuable information about interaction mechanisms between phospholipid vesicles.
Derechos: Tots els drets reservats.
Lengua: Anglès.
Documento: article ; recerca ; publishedVersion
Publicado en: Physical review. E : Statistical, nonlinear, and soft matter physics, Vol. 75, Number 2 (February 2007) , p. 021912/1-021912/10, ISSN 1539-3755

DOI: 10.1103/PhysRevE.75.021912

10 p, 220.0 KB

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