A Genome-Wide Survey of Genetic Instability by Transposition in Drosophila Hybrids
Vela Peralta, Doris Jimena (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Fontdevila, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Vieira, Cristina (Université Lyon 1. Laboratoire de Biométrie et Biologie Evolutive)
García Guerreiro, María Pilar (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)

Date:	2014
Abstract:	Hybridization between species is a genomic instability factor involved in increasing mutation rate and new chromosomal rearrangements. Evidence of a relationship between interspecific hybridization and transposable element mobilization has been reported in different organisms, but most studies are usually performed with particular TEs and do not discuss the real effect of hybridization on the whole genome. We have therefore studied whole genome instability of Drosophila interspecific hybrids, looking for the presence of new AFLP markers in hybrids. A high percentage (27-90%) of the instability markers detected corresponds to TEs belonging to classes I and II. Moreover, three transposable elements (Osvaldo, Helena and Galileo) representative of different families, showed an overall increase of transposition rate in hybrids compared to parental species. This research confirms the hypothesis that hybridization induces genomic instability by transposition bursts and suggests that genomic stress by transposition could contribute to a relaxation of mechanisms controlling TEs in the Drosophila genome.
Grants:	Ministerio de Educación y Ciencia CGL2006-13423-C02-01/02 Ministerio de Ciencia e Innovación CGL2009-12912-C03-01 Ministerio de Ciencia e Innovación CGL2010-15395 Agència de Gestió d'Ajuts Universitaris i de Recerca 2005/SGR-00995 Agència de Gestió d'Ajuts Universitaris i de Recerca 2009/SGR-636
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Transposable elements ; Invertebrate genomics ; Genetic networks ; Plant genomics ; Amplified fragment length polymorphism ; Drosophila melanogaster ; Hybridization ; Genomic databases
Published in:	PloS one, Vol. 9, Issue 2 (February 2014) , p.e88992, ISSN 1932-6203

DOI: 10.1371/journal.pone.0088992
PMID: 24586475

12 p, 422.1 KB

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