Long-Term Treatment with Citicoline Prevents Cognitive Decline and Predicts a Better Quality of Life after a First Ischemic Stroke
Álvarez Sabín, José (Universitat Autònoma de Barcelona. Departament de Medicina)
Santamarina Pérez, Estevo (Universitat Autònoma de Barcelona. Departament de Medicina)
Maisterra Santos, Olga (Universitat Autònoma de Barcelona. Departament de Medicina)
Jacas, Carlos (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Molina, Carlos (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Quintana Luque, Manuel (Hospital Universitari Vall d'Hebron)

Date:	2016
Abstract:	Stroke, as the leading cause of physical disability and cognitive impairment, has a very significant impact on patients' quality of life (QoL). The objective of this study is to know the effect of citicoline treatment in Qol and cognitive performance in the long-term in patients with a first ischemic stroke. This is an open-label, randomized, parallel study of citicoline vs. Usual treatment. All subjects were selected 6 weeks after suffering a first ischemic stroke and randomized into parallel arms. Neuropsychological evaluation was performed at 1 month, 6 months, 1 year and 2 years after stroke, and QoL was measured using the EuroQoL-5D questionnaire at 2 years. 163 patients were followed during 2 years. The mean age was 67. 5 years-old, and 50. 9% were women. Age and absence of citicoline treatment were independent predictors of both utility and poor quality of life. Patients with cognitive impairment had a poorer QoL at 2 years (0. 55 vs. 0. 66 in utility, p = 0. 015). Citicoline treatment improved significantly cognitive status during follow-up (p = 0. 005). In conclusion, treatment with long-term citicoline is associated with a better QoL and improves cognitive status 2 years after a first ischemic stroke.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Quality of life ; Ischemic stroke ; Citicoline ; Cognitive impairment
Published in:	International journal of molecular sciences, Vol. 17 Núm. 3 (March 2016) , p. 1-11, ISSN 1422-0067

DOI: 10.3390/ijms17030390
PMID: 26999113

11 p, 912.3 KB

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