Effect of surface modifications of Ti40Zr10Cu38Pd12 bulk metallic glass and Ti-6Al-4V alloy on human osteoblasts in vitro biocompatibility
Blanquer Jerez, Andreu (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Hynowska, Anna (Universitat Autònoma de Barcelona. Departament de Física)
Nogués, C. (Carme) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Ibáñez, Elena (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Sort Viñas, Jordi (Universitat Autònoma de Barcelona. Departament de Física)
Baró, M. D.. (Universitat Autònoma de Barcelona. Departament de Física)
Özkale, Berna (Institute of Robotics and Intelligent Systems (Zurich, Suïssa))
Pané i Vidal, Salvador (Institute of Robotics and Intelligent Systems (Zurich, Suïssa))
Pellicer Vilà, Eva Maria (Universitat Autònoma de Barcelona. Departament de Física)
Barrios, Leonardo (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)

Date:	2016
Abstract:	The use of biocompatible materials, including bulk metallic glasses (BMGs), for tissue regeneration and transplantation is increasing. The good mechanical and corrosion properties of Ti40Zr10Cu38Pd12 BMG and its previously described biocompatibility makes it a potential candidate for medical applications. However, it is known that surface properties like topography might play an important role in regulating cell adhesion, proliferation and differentiation. Thus, in the present study, Ti40Zr10Cu38Pd12 BMG and Ti6-Al-4V alloy were surface-modified electrochemically (nanomesh) or physically (microscratched) to investigate the effect of material topography on human osteoblasts cells (Saos-2) adhesion, proliferation and differentiation. For comparative purposes, the effect of mirror-like polished surfaces was also studied. Electrochemical treatments led to a highly interconnected hierarchical porous structure rich in oxides, which have been described to improve corrosion resistance, whereas microscratched surfaces showed a groove pattern with parallel trenches. Cell viability was higher than 96% for the three topographies tested and for both alloy compositions. In all cases, cells were able to adhere, proliferate and differentiate on the alloys, hence indicating that surface topography plays a minor role on these processes, although a clear cell orientation was observed on microscratched surfaces. Overall, our results provide further evidence that Ti40Zr10Cu38Pd12 BMG is an excellent candidate, in the present two topographies, for bone repair purposes.
Grants:	European Commission 264635 Ministerio de Ciencia e Innovación MAT2014-57960-C3-1-R Ministerio de Ciencia e Innovación MAT2014-57960-C3-3-R Ministerio de Ciencia e Innovación RYC-2012-10839 Ministerio de Ciencia e Innovación TEC2011-29140-C03 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-1015 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-524
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Cell differentiation ; Electrochemistry ; Osteoblast differentiation ; Cell adhesion ; Osteoblasts ; Cell proliferation ; Corrosion ; Surface treatments
Published in:	PloS one, Vol. 11 Issue 5 (May 2016) , p. 1-15, ISSN 1932-6203

DOI: 10.1371/journal.pone.0156644
PMID: 27243628

15 p, 14.5 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Group of Smart Nanoengineered Materials, Nanomechanics and Nanomagnetism (Gnm3)
Articles > Research articles
Articles > Published articles