| Imprint: |
Centre de Recerca Matemàtica 2012 |
| Description: |
12 p. |
| Abstract: |
Viruses rapidly evolve, and HIV in particular is known to be one of the fastest evolving human viruses. It is now commonly accepted that viral evolution is the cause of the intriguing dynamics exhibited during HIV infections and the ultimate success of the virus in its struggle with the immune system. To study viral evolution, we use a simple mathematical model of the within-host dynamics of HIV which incorporates random mutations. In this model, we assume a continuous distribution of viral strains in a one-dimensional phenotype space where random mutations are modelled by di ffusion. Numerical simulations show that random mutations combined with competition result in evolution towards higher Darwinian fitness: a stable traveling wave of evolution, moving towards higher levels of fi tness, is formed in the phenoty space. |
| Rights: |
L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons:  |
| Language: |
Anglès |
| Series: |
Centre de Recerca Matemàtica. Prepublicacions |
| Series: |
Prepublicacions del Centre de Recerca Matemàtica ; 1105 |
| Document: |
Article ; Prepublicació ; Versió de l'autor |
| Subject: |
Evolució (Biologia) -- Models matemàtics ;
VIH (Virus) ;
Mutació (Biologia) |
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