Dispersal and regulation of an adaptive mutagenesis cassette in the bacteria domain
Erill, Ivan (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Campoy Sánchez, Susana (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Mazon, Gerard (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
Barbé García, Jordi (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)

Fecha:	2006
Resumen:	Recently, a multiple gene cassette with mutagenic translation synthesis activity was identified and shown to be under LexA regulation in several proteobacteria species. In this work, we have traced down instances of this multiple gene cassette across the bacteria domain. Phylogenetic analyses show that this cassette has undergone several reorganizations since its inception in the actinobacteria, and that it has dispersed across the bacterial domain through a combination of vertical inheritance, lateral gene transfer and duplication. In addition, our analyses show that LexA regulation of this multiple gene cassette is persistent in all the phyla in which it has been detected, and suggest that this regulation is prompted by the combined activity of two of its constituent genes: a polymerase V homolog and an alpha subunit of the DNA polymerase III.
Derechos:	Tots els drets reservats.
Lengua:	Anglès
Documento:	Ressenya ; recerca ; Article ; Versió publicada
Publicado en:	Nucleic acids research, Vol. 34 (1 2006) , p. 66-77, ISSN 1362-4962

DOI: 10.1093/nar/gkj412
PMID: 16407325

12 p, 587.7 KB

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