Web of Science: 19 citations, Google Scholar: citations
Maternal History and Uterine Artery Doppler in the Assessment of Risk for Development of Early- and Late-Onset Preeclampsia and Intrauterine Growth Restriction
Llurba Olivé, Elisa (Hospital Universitari Vall d'Hebron)
Carreras Moratonas, Elena (Hospital Universitari Vall d'Hebron)
Gratacós Solsona, Eduard (Hospital Universitari Vall d'Hebron)
Juan Clar, Miquel (Hospital Son Llàtzer)
Astor, Judith (Hospital General de Granollers)
Vives, Àngels (Consorci Sanitari de Terrassa)
Hermosilla, Eduard (Hospital Universitari Vall d'Hebron)
Calero Fernández, Inés (Hospital Universitari Vall d'Hebron)
Millán Ramírez, Pilar (Hospital Universitari Vall d'Hebron)
García-Valdecasas Vilanova, Bárbara (Hospital Universitari Vall d'Hebron)
Cabero i Roura, Lluís (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Date: 2009
Abstract: Objective. To examine the value of one-step uterine artery Doppler at 20 weeks of gestation in the prediction pre-eclampsia (PE) and/or intrauterine growth restriction (IUGR). Methods. A prospective multicentre study that included all women with singleton pregnancies at 19–22 weeks of gestation (w). The mean pulsatility index (mPI) of both uterine arteries was calculated. Receiver-operating characteristics curves (ROC) were drawn to compare uterine artery Doppler and maternal risk factors for the prediction of early-onset PE and/or IUGR (before 32 w) and late-onset PE and/or IUGR. Results. 6,586 women were included in the study. Complete outcome data was recorded for 6,035 of these women (91. 6%). PE developed in 75 (1. 2%) and IUGR in 69 (1. 1%) cases. Uterine Doppler mPI was 0. 99 and the 90th centile was 1. 40. For 10% false-positive rate, uterine Doppler mPI identified 70. 6% of pregnancies that subsequently developed early-onset PE and 73. 3% of pregnancies that developed early-onset IUGR. The test had a lower detection rate for the late-onset forms of the disease (23. 5% for PE and 30% for IUGR). Maternal history has a low sensitivity in the detection of early-onset cases, although it is better at detecting late-onset PE. Conclusion. Uterine artery Doppler and maternal risk factors seem to select two different populations - early and late-onset PE which might suggest a different pathogenesis.
Note: Número d'acord de subvenció ISCIII/FIS/01-1397
Note: Número d'acord de subvenció ISCIII/FIS/02-0742
Note: Número d'acord de subvenció ISCIII/FIS/06-1213
Note: Número d'acord de subvenció ISCIII/FIS/07-1095
Note: Número d'acord de subvenció ISCIII/RETIC/RD08/0072
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Published in: Obstetrics and Gynecology International, Vol. 2009 (March 2009) , art. 275613, ISSN 1687-9597

PMID: 19936122
DOI: 10.1155/2009/275613


6 p, 553.3 KB

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Articles > Research articles
Articles > Published articles

 Record created 2017-12-20, last modified 2019-05-11



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