Histological findings in two renal transplants accomplishing operational tolerance criteria
Azancot, María A (Hospital Universitari Vall d'Hebron)
Moreso, Francesc. (Hospital Universitari Vall d'Hebron)
Cantarell, C. (Hospital Universitari Vall d'Hebron)
Torres, I. B. (Hospital Universitari Vall d'Hebron)
Serón, D. R. (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Date:	2011
Abstract:	Operational tolerance is defined as stable renal function in transplants without immunosuppression for at least 1 year. We present histological assessments of two patients with operational tolerance. The first withdrew immunosuppression in 2005 and presents stable renal function (creatinine 1. 5 mg/dL) without proteinuria. The biopsy showed mild chronic tubulointerstitial changes without inflammation. The second withdrew immunosuppression in 2009 and maintains stable renal function (creatinine 1. 6 mg/dL) with mild proteinuria. Histology showed chronic humoural rejection and Class II anti-human leukocyte antigen antibodies were detected. These cases suggest that a renal biopsy may be useful to rule out subclinical pathology in patients with operational tolerance.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	NDT Plus, Vol. 4 (march 2011) , p. 198-200, ISSN 1753-0792

DOI: 10.1093/ndtplus/sfr001
PMID: 25984157

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