Web of Science: 6 citations, Scopus: 8 citations, Google Scholar: citations
Muscular and glenohumeral changes in the shoulder after brachial plexus birth palsy : an MRI study in a rat model
Soldado Carrera, Francisco (Vall d'Hebron Institut de Recerca)
Benito Castillo, David (Fundació Hospital de l'Esperit Sant. Cirurgia ortopèdica)
García Fontecha, César Galo (Vall d'Hebron Institut de Recerca)
Barber Martínez de la Torre, Ignasi (Hospital Vall d'Hebron. Departament de Radiologia Pediàtrica)
Marotta, Mario (Vall d'Hebron Institut de Recerca)
Haddad, Sleiman (Vall d'Hebron Institut de Recerca)
Menendez, Mariano E. (Vall d'Hebron Institut de Recerca)
Mascarenhas, Vasco V. (Hospital da Luz. Centro de Imagiologia (Portugal))
Kozin, Scott H. (Temple University & Hand Surgeon. Shriners Hospital for Children. Department of Orthopaedic Surgery (USA))
Universitat Autònoma de Barcelona

Date: 2012
Abstract: Shoulder abnormalities are the major cause of morbidity in upper brachial plexus birth palsy (BPBP). We developed a rat model of upper trunk BPBP and compared our findings to previously reported animal models and to clinical findings in humans. Forty-three 5-day-old newborn rats underwent selective upper trunk neurectomy of the right brachial plexus and were studied 3 to 20 weeks after surgery. The passive shoulder external rotation was measured and the shoulder joint was assessed bilaterally by a 7. 2T MRI bilaterally. We found a marked decrease in passive shoulder external rotation, associated with a severe subscapularis muscle atrophy and contracture. None however developed the typical pattern of glenohumeral dysplasia. In contradiction with previous reports, our study shows that the rat model is not adequate for preclinical studies of shoulder dysplasia. However, it might serve as a useful model for studies analyzing shoulder contracture occurring after upper BPBP.
Note: Número d'acord de subvenció ISCIII/FIS/PI10/01357
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: article ; recerca ; publishedVersion
Subject: Shoulder anomalies following brachial plexus birth palsy ; Shoulder internal rotation contracture ; Glenohumeral dysplasia ; Erb's palsy
Published in: Journal of Brachial Plexus and Peripheral Nerve Injury, Vol. 7 (December 2012) , art. 9, ISSN 1749-7221

DOI: 10.1186/1749-7221-7-9
PMID: 23217052


7 p, 1.7 MB

The record appears in these collections:
Articles > Research articles
Articles > Published articles

 Record created 2018-01-26, last modified 2020-11-01



   Favorit i Compartir